The Diagnosis and Treatment of Parathyroid Carcinoma_West China Medical Journal

Authors：

ZHOU Yang , GONG Rixiang , LUO Shuhua , et al.

Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;

Corresponding?author：

Keywords：

甲狀旁腺癌; 診斷; 治療

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:總結和探討甲狀旁腺癌的診斷和治療方法。方法:回顧性總結本院5例甲狀旁腺癌的臨床資料。結果:5例患者術前頸部均捫及質硬包塊,平均血鈣濃度為3.82 mmol/L,平均PTH濃度為153.6 pmol/L,4例術中發現周圍浸潤表現。5例中4例同時行甲狀旁腺腫瘤和同側甲狀腺腺葉切除,1例僅行甲狀旁腺腫瘤切除。5例術后均診斷為甲狀旁腺癌。術后4例得到隨訪,時間4月～5年。其中2例術后無復發;1例于術后半年局部復發行患側甲狀腺切除,后無復發;1例因全身轉移于術后8個月死亡。結論:甲狀旁腺癌的診斷非常困難,異常高濃度血鈣、血PTH及術中浸潤表現和組織病理學特征是甲狀旁腺癌診斷的重要依據,99m-Tc-MIBI掃描及超聲是病變定位的首選手段,腫瘤及其周圍受侵組織的“整塊切除”(en bloc resection)是首選的治療方式。

Citation： ZHOU Yang,GONG Rixiang,LUO Shuhua,et al.. The Diagnosis and Treatment of Parathyroid Carcinoma. West China Medical Journal, 2009, 24(3): 579-581. doi: Copy

1.
2.
3.	RAWAT N,KHETAN N,WILLIAMS DW,et al.Parathyroid carcinoma[J].B J Surg,2005,92(11):1345－1353..
4.	MONTENEGRO FL,TAVARES MR,DURAZZO MD,et al.Clinical suspicion and parathyroid carcinoma management[J].Sao Paulo Med J,2006,124(1):42－44..
5.	周建平,田雨霖.中國人原發性甲狀旁腺功能亢進10年文獻回顧[J].中國普通外科雜志,2007,16(1):78－80..
6.	ELIZABETH A,MITTENDOR F,MCHENRY CR.Parathyroid Carcinoma[J].Adv Anat Pathol,2005,12:53－61..
7.	李進,肖海鵬.甲狀旁腺癌研究進展[J].國外醫學雜志,2005,32(6):243－246,273..
8.	KEBEBEW E.Parathyroid carcinoma[J].Curr Treat Options Oncol,2001,2:347－354..
9.	FERNANDEZRANVIER GG,KHANAFSHAR E,JENSEN K,et al.Parathyroid carcinoma,atypical parathyroid adenoma,or parathyromatosis?[J]Cancer,2007,110(2):255－264..
10.	THOMPSON SD,PRICHARD AJN.The management of parathyroid carcinoma[J].Curr Opin Otolaryngol Head Neck Surg,2004,12:93－97..
11.	ERICKSON LA,LONG J,WOLLAR P,et al.Parathyroid hyperplasia,adenomas and carcinomas:differential expression of p27Kip1 protein[J].Am J Surg Pathol,1999,23:288－295..
12.	STOJADINOVIC A,HOOS A,NISSAN A,et al.Parathyroid neoplasms:clinical,histopathological and tissue microarraybased molecular analysis[J].Hum Pathol,2003,34:54－64..
13.	VASEF MA,BRYNES RK,STURM M,et al.Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias[J].Mod Pathol,1999,12:412－416.

1.
2.
3. RAWAT N,KHETAN N,WILLIAMS DW,et al.Parathyroid carcinoma[J].B J Surg,2005,92(11):1345－1353..
4. MONTENEGRO FL,TAVARES MR,DURAZZO MD,et al.Clinical suspicion and parathyroid carcinoma management[J].Sao Paulo Med J,2006,124(1):42－44..
5. 周建平,田雨霖.中國人原發性甲狀旁腺功能亢進10年文獻回顧[J].中國普通外科雜志,2007,16(1):78－80..
6. ELIZABETH A,MITTENDOR F,MCHENRY CR.Parathyroid Carcinoma[J].Adv Anat Pathol,2005,12:53－61..
7. 李進,肖海鵬.甲狀旁腺癌研究進展[J].國外醫學雜志,2005,32(6):243－246,273..
8. KEBEBEW E.Parathyroid carcinoma[J].Curr Treat Options Oncol,2001,2:347－354..
9. FERNANDEZRANVIER GG,KHANAFSHAR E,JENSEN K,et al.Parathyroid carcinoma,atypical parathyroid adenoma,or parathyromatosis?[J]Cancer,2007,110(2):255－264..
10. THOMPSON SD,PRICHARD AJN.The management of parathyroid carcinoma[J].Curr Opin Otolaryngol Head Neck Surg,2004,12:93－97..
11. ERICKSON LA,LONG J,WOLLAR P,et al.Parathyroid hyperplasia,adenomas and carcinomas:differential expression of p27Kip1 protein[J].Am J Surg Pathol,1999,23:288－295..
12. STOJADINOVIC A,HOOS A,NISSAN A,et al.Parathyroid neoplasms:clinical,histopathological and tissue microarraybased molecular analysis[J].Hum Pathol,2003,34:54－64..
13. VASEF MA,BRYNES RK,STURM M,et al.Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias[J].Mod Pathol,1999,12:412－416.

West China Medical Journal

The Diagnosis and Treatment of Parathyroid Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content