Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial_West China Medical Journal

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Department of Abdominal Oncology,West China Hospital,Sichuan University,Chengdu 610041,China;

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Keywords：

醋酸甲地孕酮; 化療; 惡心; 嘔吐

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目的:觀察醋酸甲地孕酮(MA)在預防化療引起的消化道反應中的作用。方法:收集2007年6月～2008年6月病理學和細胞學證實的消化道惡性腫瘤60例,采用自身前后交叉對照研究,隨機分為AB和BA兩組。AB組第一周期止吐方案用格拉司瓊+胃復安＋MA,第二周期止吐方案用格拉司瓊+胃復安;BA組第一周期止吐方案用格拉司瓊+胃復安,第二周期止吐方案MA＋格拉司瓊+胃復安。結果:化療同時配合使用MA惡心、嘔吐發生率下降(P lt;0.05);惡心、嘔吐程度改善(P.001),并且可以預防化療引起的急性期和延遲期惡心、嘔吐反應(P lt;0.05)。結論:化療同時配合使用MA可以改善化療患者的惡心嘔吐反應

Citation： HOU Ming,ZANG Jian,GOU Hongfeng,et al. Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial. West China Medical Journal, 2009, 24(3): 592-594. doi: Copy

1.
2.	SCHNELL FM,Chemotherapyinduced nausea and vomiting:the importance of acute antiemetic control[J].Oncologist,2003,8(2):187-198..
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4.	HESKTH PJ,KRIS MG,GRUNBERG SM,et al.Proposal for classifying the acute emetogenicity of cancer chemotherapy[J].J Clin Oncol,1997,15(1):103-109..
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6.	GRALLA R,LICHINITSER M,SLEEBOOM H,et al.Palonosetron improves prevention of chemotherapyinduced nausea and vomiting following moderately emetogenic chemotherapy:results of a doubleblind randomized phase Ⅲ trial comparing single doses of palonosetron with ondansetron[J].Ann Oncol,2003,14(9):1570-1577..
7.	BERENSTEIN EG,RTIZ Z.Megestrol acetate for the treatment of anorexiacachexia syndrome[J].Cochrane Database Syst Rev,2005,(2):CD004310..
8.	孫燕.內科腫瘤學[M].北京:人民衛生出版社,2003:995..
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10.	邵紅玲.格拉司瓊與甲氧氯普胺聯合應用預防化療惡心嘔吐臨床療效觀察[J].實用醫技雜志,2007,14(28):3925..
11.	韓冬,郭杰.恩丹西酮預防化療中胃腸道反應的臨床觀察[J].河北醫學,2004,10(10):930-931..
12.	王梅子,許建衡.化療止吐藥物的研究進展[J].汕頭大學醫學院學報,2008,21(2):124..
13.	崔慧娟.醋酸甲地孕酮在晚期腫瘤治療中的應用進展[J].國外醫學腫瘤學分冊,2001,28(6):473-474..
14.	ULUTIN HC,ARPACI F,PAK Y,et al.Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer:a randomized study comparing two different doses [J].Tumori,2002,88(4):277-280..
15.	ROWLAND KMJR,LOPRINZI CL,SHAW EG,et al.Randomized doubleblind placebocontrolled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensivestage smallcell lung cancer:a North Central Cancer Treatment Group study[J].J Clin Oncol,1996,14(1):135-141..
16.	王啟船,王青,孫曉,等.甲地孕酮改善腫瘤患者化療期消化道反應療效觀察[J].中國誤診學雜志,2006,6(23):4572..
17.	何舒.化療止吐藥的研究進展[J].國外醫學藥學分冊,2003,30(6):334..

1.
2. SCHNELL FM,Chemotherapyinduced nausea and vomiting:the importance of acute antiemetic control[J].Oncologist,2003,8(2):187-198..
3. GLAUSL A,KNIPPING C,MORANT R,et al.Chemotherapyinduced nausea and vomiting in routine practice:a European perspective[J].Support Care Cancer,2004,12(10):708-715..
4. HESKTH PJ,KRIS MG,GRUNBERG SM,et al.Proposal for classifying the acute emetogenicity of cancer chemotherapy[J].J Clin Oncol,1997,15(1):103-109..
5. AAPRO MS,GRUNBERG SM,MANIKHAS GM,et al.A phase Ⅲ,doubleblind,randomized trial of palonosetron compared with ondansetron in preventing chemotherapyinduced nausea and vomiting following highly emetogenic chemotherapy[J].Ann Oncol,2006,17(9):1441-1449..
6. GRALLA R,LICHINITSER M,SLEEBOOM H,et al.Palonosetron improves prevention of chemotherapyinduced nausea and vomiting following moderately emetogenic chemotherapy:results of a doubleblind randomized phase Ⅲ trial comparing single doses of palonosetron with ondansetron[J].Ann Oncol,2003,14(9):1570-1577..
7. BERENSTEIN EG,RTIZ Z.Megestrol acetate for the treatment of anorexiacachexia syndrome[J].Cochrane Database Syst Rev,2005,(2):CD004310..
8. 孫燕.內科腫瘤學[M].北京:人民衛生出版社,2003:995..
9. 南克俊,魏永長,李春麗,等.甲地孕酮改善晚期惡性腫瘤患者生活質量[J].第四軍醫大學學報,2002,23(4):350..
10. 邵紅玲.格拉司瓊與甲氧氯普胺聯合應用預防化療惡心嘔吐臨床療效觀察[J].實用醫技雜志,2007,14(28):3925..
11. 韓冬,郭杰.恩丹西酮預防化療中胃腸道反應的臨床觀察[J].河北醫學,2004,10(10):930-931..
12. 王梅子,許建衡.化療止吐藥物的研究進展[J].汕頭大學醫學院學報,2008,21(2):124..
13. 崔慧娟.醋酸甲地孕酮在晚期腫瘤治療中的應用進展[J].國外醫學腫瘤學分冊,2001,28(6):473-474..
14. ULUTIN HC,ARPACI F,PAK Y,et al.Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer:a randomized study comparing two different doses [J].Tumori,2002,88(4):277-280..
15. ROWLAND KMJR,LOPRINZI CL,SHAW EG,et al.Randomized doubleblind placebocontrolled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensivestage smallcell lung cancer:a North Central Cancer Treatment Group study[J].J Clin Oncol,1996,14(1):135-141..
16. 王啟船,王青,孫曉,等.甲地孕酮改善腫瘤患者化療期消化道反應療效觀察[J].中國誤診學雜志,2006,6(23):4572..
17. 何舒.化療止吐藥的研究進展[J].國外醫學藥學分冊,2003,30(6):334..

West China Medical Journal

Megestrol Acetate Used To Prevent Chemotherapyinduced Gastrointestinal Reactions:A Clinical Trial

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