Patient Controlled Sedation with Low Dose of Propofol and Sufentanil in Colonoscopy_West China Medical Journal

Authors：

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041,China;

Corresponding?author：

Keywords：

舒芬太尼; 異丙酚; 自控鎮靜鎮痛; 結腸鏡

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:觀察舒芬太尼復合異丙酚自控鎮靜鎮痛在結腸鏡檢查中的效果及不良反應,從而探討該方法的安全性和有效性。方法:行無痛纖維結腸鏡檢查的患者60例,隨機分為兩組:自控鎮痛/鎮靜組和靜脈復合全麻醉組,每組30例。自控鎮痛/鎮靜組首先緩慢靜脈注射舒芬太尼0.12 μg/kg,隨之接電子自控鎮痛泵,負荷量設定為0.5 mg/kg,以4 mg/kg·h的速度持續泵入異丙酚(10 mg/mL),術中按壓1次自控手柄可快速推注異丙酚1 mL。靜脈復合全麻醉組首先靜脈緩慢推注芬太尼1 μg/kg,咪唑安定0.02 mg/kg, 2 min后緩慢推注異丙酚0.8～1 mg/kg。術中間斷給予異丙酚以維持聽覺誘發電位指數(AAI)于30～40之間。結果:靜脈復合全麻醉組的MAP較檢查前明顯下降且較自控鎮痛/鎮靜組下降更為明顯且具有統計學意義(P lt;0.05)。自控鎮痛/鎮靜組的呼吸頻率較靜脈復合全麻醉組下降明顯且在T3時間點具有統計學意義(P lt;0.05)。自控鎮痛/鎮靜組患者OAA/S評分達5分和Aldrete評分達9分的時間均較靜脈復合全麻醉組明顯縮短(1.4±1.3 VS 3.9±1.7和 2.9±1.7 VS 5.7±1.7)(P lt;0.05)。兩組的內鏡醫師和患者滿意度評分無統計學差異(P＞0.05)。結論:自控鎮靜鎮痛能夠比傳統的靜脈全身麻醉提供更良好的循環系統穩定性,更迅速的麻醉后恢復,是結腸鏡檢查鎮靜鎮痛的理想和安全方法。

Citation： SONG Huayong,LI Junxiang,Liu juan,WANG Xiao,et al. Patient Controlled Sedation with Low Dose of Propofol and Sufentanil in Colonoscopy. West China Medical Journal, 2009, 24(4): 898-901. doi: Copy

1.	WILLIAMS CB. Comfort and quality in colonoscopy [J]. Gastrointest Endsoc, 1994,40:769-70..
2.	CHERNIK D A, GILLINGS D, LAINE H, et al. Validity and reliability of the Observer’s assessment of Alertness/Sedation Scale: study with intravenous midazolam[J]. J Clin Psychopharmacol,1990,10:244-251..
3.	ALDRETE A. The post-anesthesia recovery score revisited[J]. J Clin Anaesth, 1995,8:415-421..
4.	SUMPELMANN R, BUSING H, SCHRODER D, REKERSBRINK M, KROHN S, STRAUSS JM. Patient-controlled analgesia with clonidine and piritramide[J]. Anaesthesist, 1996,45:88-94..
5.	MURKIN JM. Sufentanil anesthesia for major surgery: the multicentre Canadian clinical trial[J]. Can J Anaesth,1989,36(3):343-349..
6.	NELSON D B, FREEMAN M L, SILVISSE, et al. A randomized, controlled trial of transcutaneous cardon dioxide monitoring during ERCP[J]. Gastrointest Endosc,2000,51:288-295..
7.	DOI M, GAJRAJ RJ, MANTZARIDIS H, KENNY GNC. Prediction of movement at laryngeal mask airway insertion: comparison of auditory evoked potential index, bispectral index, spectral edge frequency and median frequency[J]. Br J Anaesth, 1999,82:203-207.

1. WILLIAMS CB. Comfort and quality in colonoscopy [J]. Gastrointest Endsoc, 1994,40:769-70..
2. CHERNIK D A, GILLINGS D, LAINE H, et al. Validity and reliability of the Observer’s assessment of Alertness/Sedation Scale: study with intravenous midazolam[J]. J Clin Psychopharmacol,1990,10:244-251..
3. ALDRETE A. The post-anesthesia recovery score revisited[J]. J Clin Anaesth, 1995,8:415-421..
4. SUMPELMANN R, BUSING H, SCHRODER D, REKERSBRINK M, KROHN S, STRAUSS JM. Patient-controlled analgesia with clonidine and piritramide[J]. Anaesthesist, 1996,45:88-94..
5. MURKIN JM. Sufentanil anesthesia for major surgery: the multicentre Canadian clinical trial[J]. Can J Anaesth,1989,36(3):343-349..
6. NELSON D B, FREEMAN M L, SILVISSE, et al. A randomized, controlled trial of transcutaneous cardon dioxide monitoring during ERCP[J]. Gastrointest Endosc,2000,51:288-295..
7. DOI M, GAJRAJ RJ, MANTZARIDIS H, KENNY GNC. Prediction of movement at laryngeal mask airway insertion: comparison of auditory evoked potential index, bispectral index, spectral edge frequency and median frequency[J]. Br J Anaesth, 1999,82:203-207.

West China Medical Journal

Patient Controlled Sedation with Low Dose of Propofol and Sufentanil in Colonoscopy

Abstract Full text Figures/Tables Video References Cited by

Format

Content