目的:觀察等效劑量瑞芬太尼和芬太尼誘導氣管插管對小兒血流動力學的影響。方法:40例擇期行全麻患兒隨機分為瑞芬太尼組和芬太尼組,麻醉誘導使用咪唑安定0.15mg/kg、丙泊酚2.5mg/kg、芬太尼2.5μg/kg或瑞芬太尼2μg/kg和維庫溴銨0.1mg/kg。分別于麻醉誘導前(T0)、誘導后2min(T1)、插管后1、2min(T2、T3)記錄心率、收縮壓和舒張壓。結果:兩組誘導前血流動力學指標相似。與T0時比較,兩組患兒T1時收縮壓、舒張壓均降低(P lt;0.05或P lt;0.01),心率均減慢(P lt;0.05或P lt;0.01);瑞芬太尼組T2.T3時收縮壓、舒張壓降低(P lt;0.05或P lt;0.01),心率減慢(P lt;0.05);芬太尼組T2、T3時收縮壓、舒張壓升高(P lt;0.05),心率增快(P lt;0.05)。與芬太尼組比較,瑞芬太尼組T1、T2和T3時收縮壓、舒張壓均降低(P lt;0.05),心率減慢(P lt;0.05)。結論:瑞芬太尼比等效劑量芬太尼能更好地抑制小兒全麻誘導氣管插管時的心血管反應。
Citation：
XU Li,WANG Jian,LUO Linli.. Comparison of Remifentanil and Fentanyl during Induction of Pediatric Anaesthesia. West China Medical Journal, 2009, 24(5): 1211-1212. doi:
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