姜黃素抗腫瘤機制研究進展_West China Medical Journal

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林琳 , 王平 , 尹如鐵 , 王丹青

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Citation： 林琳,王平,尹如鐵,王丹青. 姜黃素抗腫瘤機制研究進展. West China Medical Journal, 2009, 24(5): 1320-1322. doi: Copy

1.	王箴.化工辭典.第4版[M].北京:化學工業出版社,2001:459.
2.	KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
3.	ODOT J,ALBERT P,CARLIER A, et al. In vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
4.	CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
5.	CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
6.	BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
7.	劉立民,孔祥波,常喜華,等.姜黃素對前列腺癌PC3M細胞生長抑制和凋亡的影響[J].吉林大學學報:醫學版,2007,33(2):283-285.
8.	鄭麗端,童強松,吳翠環,等.姜黃素誘導卵巢癌細胞株A2780細胞周期阻滯和凋亡[J].華中科技大學學報(醫學版),2003,32(2):209-211.
9.	吳勇,陳元仲,許建華,等.姜黃素對人類Burkitt淋巴瘤抗癌作用的研究[J].中華腫瘤雜志,2002,24(4):348-351.
10.	田慧軍,王笛樂.姜黃素誘導人結腸癌細胞株SW480凋亡及其bcl2表達相關性研究[J].腫瘤防治研究,2006,33(3):185-187.
11.	RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
12.	ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
13.	LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
14.	LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
15.	GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
16.	GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
17.	BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
18.	BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
19.	CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
20.	CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
21.	DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
22.	DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
23.	PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
24.	PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
25.	HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
26.	HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
27.	ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
28.	ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
29.	張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學雜志,2003,18(3):172-174.
30.	張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學雜志,2003,18(3):172-174.
31.	英煥春,張淑蘭,呂靖.姜黃素逆轉卵巢癌耐藥細胞株COC1/DDP耐藥性及機制的研究[J].現代腫瘤醫學,2007,15(5):604-607.
32.	英煥春,張淑蘭,呂靖.姜黃素逆轉卵巢癌耐藥細胞株COC1/DDP耐藥性及機制的研究[J].現代腫瘤醫學,2007,15(5):604-607.
33.	CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
34.	CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
35.	PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
36.	PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
37.	李昱辰,仲來福.姜黃素對順鉑所致大鼠腎毒性的防護作用及其可能機制[J].毒理學雜志,2005,19(3):270.
38.	李昱辰,仲來福.姜黃素對順鉑所致大鼠腎毒性的防護作用及其可能機制[J].毒理學雜志,2005,19(3):270.
39.	張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機制研究[J].時珍國醫國藥,2007,18(7):1673-1675.
40.	張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機制研究[J].時珍國醫國藥,2007,18(7):1673-1675.
41.	孫雅煊,王振華,李剛,等.姜黃素降低環磷酰胺致微核形成率[J].蘭州大學學報(醫學版),2006,32(3):27-30.
42.	孫雅煊,王振華,李剛,等.姜黃素降低環磷酰胺致微核形成率[J].蘭州大學學報(醫學版),2006,32(3):27-30.
43.	WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
44.	WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
45.	BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
46.	BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
47.	SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.
48.	SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.

1. 王箴.化工辭典.第4版[M].北京:化學工業出版社,2001:459.
2. KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
3. ODOT J,ALBERT P,CARLIER A, et al. In vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
4. CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
5. CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
6. BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
7. 劉立民,孔祥波,常喜華,等.姜黃素對前列腺癌PC3M細胞生長抑制和凋亡的影響[J].吉林大學學報:醫學版,2007,33(2):283-285.
8. 鄭麗端,童強松,吳翠環,等.姜黃素誘導卵巢癌細胞株A2780細胞周期阻滯和凋亡[J].華中科技大學學報(醫學版),2003,32(2):209-211.
9. 吳勇,陳元仲,許建華,等.姜黃素對人類Burkitt淋巴瘤抗癌作用的研究[J].中華腫瘤雜志,2002,24(4):348-351.
10. 田慧軍,王笛樂.姜黃素誘導人結腸癌細胞株SW480凋亡及其bcl2表達相關性研究[J].腫瘤防治研究,2006,33(3):185-187.
11. RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
12. ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
13. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
14. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
15. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
16. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
17. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
18. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
19. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
20. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
21. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
22. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
23. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
24. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
25. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
26. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
27. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
28. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
29. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學雜志,2003,18(3):172-174.
30. 張慧珠,楊林,李小娜,等.姜黃素體外增敏抗腫瘤藥物作用[J].華西藥學雜志,2003,18(3):172-174.
31. 英煥春,張淑蘭,呂靖.姜黃素逆轉卵巢癌耐藥細胞株COC1/DDP耐藥性及機制的研究[J].現代腫瘤醫學,2007,15(5):604-607.
32. 英煥春,張淑蘭,呂靖.姜黃素逆轉卵巢癌耐藥細胞株COC1/DDP耐藥性及機制的研究[J].現代腫瘤醫學,2007,15(5):604-607.
33. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
34. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
35. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
36. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
37. 李昱辰,仲來福.姜黃素對順鉑所致大鼠腎毒性的防護作用及其可能機制[J].毒理學雜志,2005,19(3):270.
38. 李昱辰,仲來福.姜黃素對順鉑所致大鼠腎毒性的防護作用及其可能機制[J].毒理學雜志,2005,19(3):270.
39. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機制研究[J].時珍國醫國藥,2007,18(7):1673-1675.
40. 張英,王順蓉,陳蓉,等.姜黃素抗順鉑腎毒性作用及其機制研究[J].時珍國醫國藥,2007,18(7):1673-1675.
41. 孫雅煊,王振華,李剛,等.姜黃素降低環磷酰胺致微核形成率[J].蘭州大學學報(醫學版),2006,32(3):27-30.
42. 孫雅煊,王振華,李剛,等.姜黃素降低環磷酰胺致微核形成率[J].蘭州大學學報(醫學版),2006,32(3):27-30.
43. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
44. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
45. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
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West China Medical Journal

姜黃素抗腫瘤機制研究進展

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