Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease_West China Medical Journal

Authors：

CHEN Li , HE Li Hua , YANG Wen Bo.

The Central Hospital of Suining, Department of Nuclear Medicine, SiChuan Suining, 629000 China;

Corresponding?author：

Keywords：

腺苷; 冠心病; 心肌灌注顯像

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:評價國產腺苷臨床應用安全性及腺苷負荷心肌灌注顯像對冠心病的診斷價值。方法:對51例臨床疑診冠心病患者,分別靜脈注射腺苷,注射3min末,靜脈注射核素顯像劑99TcmMIBI 925 MBq,1～1.5h行心肌灌注斷層顯像,分析患者在腺苷注入后的血流動力學改變、副作用發生情況。經半年以上隨訪排除或確診冠心病,評價腺苷負荷心肌灌注顯像對冠心病的診斷價值。結果:腺苷輸注后,86.3%(44/51) 患者出現各種副作用,停藥后均很快緩解。腺苷負荷試驗心肌灌注顯像診斷冠心病的敏感性90.9%,特異性71.4%,準確性88.2%,陽性預測值95.2%,陰性預測值55.6%。結論:國產腺苷可安全地應用于負荷心肌灌注顯像。腺苷負荷心肌灌注顯像診斷冠心病敏感性較高,具有重要的臨床應用價值。

Citation： CHEN Li,HE Li Hua,YANG Wen Bo.. Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease. West China Medical Journal, 2009, 24(6): 1468-1470. doi: Copy

1.	NEWBY A C. Adenosine and the concept of retaliatory metabolites[J]. Trends Biochem Sci,1984,9(1):42-44.
2.	MARWICK T H. Current status of stress echocardiography for diagnosis and prognostic assessment of cornary artery disease[J]. Coron Artery Dis,1998,9(2):411-426.
3.	CERQYEURA M D, VERANI M S, SCHWAIGER M, et al. Safety profile ofadenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry[J]. J Am Coll Cardiol,1994,23(2):384-389 .
4.	田月琴,王金城,何作祥,等.腺苷負荷試驗心肌灌注顯像診斷冠心病的臨床價值[J].中華心血管病雜志,2005,33(1):58-60.
5.	馮雪鳳,賈支俊,許守林,等.腺苷負荷實驗:99 mTc-MIBI心肌灌注顯像中不良反應的觀察[J].實用診斷與治療,2008,22(1):24-26.
6.	付巍,劉韜,董慶華,等.國產腺苷藥物負荷試驗210例臨床安全性評價[J].山西醫藥雜志,2008,37(1):6-8.
7.	王倩,王金城,米宏志,等.國產腺苷介入心肌灌注斷層顯像對心肌缺血的診斷價值[J].中華核醫學雜志,2006,26 (2):81.

1. NEWBY A C. Adenosine and the concept of retaliatory metabolites[J]. Trends Biochem Sci,1984,9(1):42-44.
2. MARWICK T H. Current status of stress echocardiography for diagnosis and prognostic assessment of cornary artery disease[J]. Coron Artery Dis,1998,9(2):411-426.
3. CERQYEURA M D, VERANI M S, SCHWAIGER M, et al. Safety profile ofadenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry[J]. J Am Coll Cardiol,1994,23(2):384-389 .
4. 田月琴,王金城,何作祥,等.腺苷負荷試驗心肌灌注顯像診斷冠心病的臨床價值[J].中華心血管病雜志,2005,33(1):58-60.
5. 馮雪鳳,賈支俊,許守林,等.腺苷負荷實驗:99 mTc-MIBI心肌灌注顯像中不良反應的觀察[J].實用診斷與治療,2008,22(1):24-26.
6. 付巍,劉韜,董慶華,等.國產腺苷藥物負荷試驗210例臨床安全性評價[J].山西醫藥雜志,2008,37(1):6-8.
7. 王倩,王金城,米宏志,等.國產腺苷介入心肌灌注斷層顯像對心肌缺血的診斷價值[J].中華核醫學雜志,2006,26 (2):81.

West China Medical Journal

Safety Evaluation and Diagnostic Value of Domesticmade Adenosine in Pharmacological Stress with Myocardial Perfusion Imaging for Coronary Artery Disease

Abstract Full text Figures/Tables Video References Cited by

Format

Content