不同周齡SD大鼠外耳道腺結構與藥物臨床前安全性評價_《華西醫學》

作者：

1.四川大學華西醫院國家成都中藥安全性評價中心;2.成都華西海圻醫藥科技有限公司;3.四川大學公共衛生學院,四川成都 610041;

關鍵詞：

SD大鼠外耳道腺藥物評價

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目的:探討大鼠外耳道腺的正常組織結構及年齡組間,雌雄動物間有無差異,以期為藥物評價過程中藥物對耳腺影響的評價提供客觀的依據。方法:將20只同齡SD大鼠隨即分為A和B兩組,每組均雌雄各半,分別與12周和17周齡處死,取外耳道腺進行病理學分析。觀察外耳道腺在不同年齡組間、雌雄組間有無區別。結果:A組動物雌雄組間外耳道腺的組織結構無明顯差異。B組動物雌雄動物間外耳道腺的組織結構無明顯差異。A組雌性動物與B組雌性動物間外耳道腺的組織結構無明顯差異。A組雄性動物與B組雄性動物間外耳道腺的組織結構無明顯差異。結論:SD大鼠外耳道腺的組織結構在雌雄動物間及年齡在12周及17周間無明顯差異,因此在進行藥物對耳腺的影響的評價過程中12周齡和17周齡的受試大鼠所得到的結果應具備可比性。

引用本文： 杜艷春,邱爽,陳珂,華曉萍,李宏霞,岑小波,王莉,石桂秀,胡春燕. 不同周齡SD大鼠外耳道腺結構與藥物臨床前安全性評價. 華西醫學, 2009, 24(7): 1764-1766. doi: 復制

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1. SEELY J. Auditory sebaceous glands (Zymbal’s glands)[J]. Pathobiol Aging Rat,1994,2:423-433..
2. YAMAZAKI K, AISO S, MATSUMOTO M, et al. Carcinogenicity and chronic toxicity of 1,4dichloro 2nitrobenzene in rats and mice by two years feeding[J]. Ind Health,2006,44(2):230-243..
3. QUAST J F. Twoyear toxicity and oncogenicity study with acrylonitrile incorporated in the drinking water of rats[J]. Toxicol Letters,2002,132(3):153-196..
4. MEHLMAN M A. Carcinogenic effects of benzene: Cesare Maltoni’s contributions[J]. Ann N Y Acad Sci,2002,982:137-148..
5. FRIEDMAN M A, BELILES R P. Threegeneration reproduction study of rats receiving acrylonitrile in drinking water[J]. Toxicol Letters,2002,132(3):249-261..
6. BELPOGGI F, SOFFRITTI M, GUARINO M, et al. Results of longterm experimental studies on the carcinogenicity of ethylenebisdithiocarbamate (Mancozeb) in rats[J]. Ann N Y Acad Sci,2002,982:123-136..
7. MALTONI C, COTTI G, VALGIMIGLI L, et al. Zymbal gland carcinomas in rats following exposure to benzene by inhalation[J]. Am J Industrial Med,1982,3(1):11-16..
8. OWEN P E, GLAISTER J R, GAUNT I F, et al. Inhalation toxicity studies with 1,3butadiene. 3. Two year toxicity/carcinogenicity study in rats[J]. Am Ind Hyg Assoc J,1987,48(5):407-413..
9. TAKAYAMA S, NAKATSURU Y, SATO S. Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats[J]. Jpn J Cancer Res,1987,78(10):1068-1072..

《華西醫學》

不同周齡SD大鼠外耳道腺結構與藥物臨床前安全性評價

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《華西醫學》

不同周齡SD大鼠外耳道腺結構與藥物臨床前安全性評價

摘要 全文 圖表 視頻 參考文獻 施引文獻 補充材料

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Content

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