Impact on Quality of Life of Botulinus Toxin A Injection for Hemifacial Spasm_West China Medical Journal

Authors：

LI Qifu ^1,2 , ZHENG Hongbo ¹ , JIANG Yi. ¹

Department of Neurology, West China Hospital, Sichuan University, Chengdu Sichuan 610041, China;

Corresponding?author：

Keywords：

A型肉毒毒素; 面肌痙攣; 生存質量

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目的:觀察A型肉毒毒素(BTXA)對面肌痙攣(HFS)患者痙攣程度的改善和生存質量的影響。方法: 對68例HFS患者進行局部注射BTXA,治療前及治療后1個月分別對患者的痙攣程度進行判定和使用世界衛生組織生存質量評定量表簡表(WHOQOL-BREF)評價生存質量。結果: 97.04%的HFS患者在BXTA治療后1個月痙攣明顯改善緩解,而且患者在WHOQOL-BREF的生理領域、心理領域、社會關系領域、總的健康狀況和總的生存質量的評分均明顯高于治療前,差異有統計學意義(P lt;0.01)。結論: 局部注射BTXA可迅速緩解或消除HFS患者肌肉痙攣,提高患者的生存質量。

Citation： LI Qifu,ZHENG Hongbo,JIANG Yi.. Impact on Quality of Life of Botulinus Toxin A Injection for Hemifacial Spasm. West China Medical Journal, 2009, 24(8): 1923-1925. doi: Copy

1.	SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
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5.	SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
6.	SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
7.	SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
8.	SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
9.	郝元濤,方積乾.世界衛生組織生存質量測定量表中文版介紹及其應用說明[J].現代康復,2000,4:1127-1129.
10.	WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
11.	鐘萍,蔣毅. A型肉毒毒素治療半側面肌痙攣的臨床療效評價[J].現代生物醫學進展,2006,6:44-45.

1. SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
2. COHEN DA,SAVINO P,STERN MB,et al.Botulinum injection therapy for blepharospasm:a review and report of 75 patients[J].Chn Neuropharmacol,1986,9:415.
3. 郝元濤,方積乾,李彩霞,等.世界衛生組織生存質量量表及其中文版介紹及其應用說明[J].國外醫學社會醫學分冊,1999,16:118-122.
4. JOST WH,KOHL A.Botulinum toxin:evidencebased medicine criteria in blepharospasm and hemifacial spasm[J].Neurol,2001,248:S21-S24.
5. SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
6. SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
7. SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
8. SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
9. 郝元濤,方積乾.世界衛生組織生存質量測定量表中文版介紹及其應用說明[J].現代康復,2000,4:1127-1129.
10. WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
11. 鐘萍,蔣毅. A型肉毒毒素治療半側面肌痙攣的臨床療效評價[J].現代生物醫學進展,2006,6:44-45.

West China Medical Journal

Impact on Quality of Life of Botulinus Toxin A Injection for Hemifacial Spasm

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