The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma_West China Medical Journal

Authors：

LI ling ¹ , YANG Hong ² , LI Ke ² , et al ²

1 Institute of Dermatology and Venereology of Sichuan Provincial Provincial People,s Hospital,Chengdu Sichuan 610072;2Department of Pathology,Sichuan Provincial Provincial People,s Hospital,Chengdu Sichuan 610072,China;

Corresponding?author：

Keywords：

CyclinD1; P16; 皮膚鱗狀細胞癌; 免疫組織化學

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目的:觀察CyclinD1,P16在皮膚鱗狀細胞癌組織中的表達,探討CyclinD1,P16在皮膚鱗狀細胞癌發生發展中的作用。方法:用免疫組織化學技術檢測40例皮膚鱗癌石蠟包埋組織和10例正常皮膚組織的CyclinD1,P16表達。結果:CyclinD1在皮膚鱗癌組織中表達高于皮膚正常對照組,兩者差異有顯著統計學意義(P lt;0.01); P16在皮膚鱗癌組織中表達低于皮膚正常對照組,但兩者差異無顯著統計學意義(P gt;0.05);CyclinD1,P16在皮膚鱗癌中表達呈正相關性(r=0.782,P lt;0.01)。結論:CyclinD1在皮膚鱗狀細胞癌組織中陽性表達上調,P16在皮膚鱗狀細胞癌組織中陽性表達下調,CyclinD1,P16在皮膚鱗癌中表達呈正相關。

Citation： LI ling,YANG Hong,LI Ke,et al. The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma. West China Medical Journal, 2009, 24(8): 2042-2044. doi: Copy

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1. 陳意生主編.腫瘤分子細胞生物學[M].北京:人民軍醫出版社,2002:291-308.
2. RESNITZKY D, GOSSEN M, BUJARD H,et al.l Acceleration of theG1/ S phase transition by expression of cyclinD1 and E with an inducible system[J]. MolCellBio, 1994, 14(3): 1669-1679.
3. 韋立蓓,濮德敏,尹伶.角化型外陰鱗狀細胞癌中p16和cyclin D1蛋白的表達[J].臨床與實驗病理學雜志, 2007,23(5):617-618.
4. LUKAS J, AAGAARD L, STRAUSS M, et al. Oncogenic aberrations ofp16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control[J].Cancer Res, 1995,55:4818-4823.
5. OKAMI K, REED AL, CAIRNS P, et al. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma[J]. Oncogene, 1999,18:3541-3545.
6. VICTORIA L, BROWN, CATHERINE A, et al. p16INK4a and p14ARF Tumor Suppressor Genes Are Commonly Inactivated in Cutaneous Squamous Cell Carcinoma[J]. Journal of Investigative Dermatology, 2004,122: 1284-1292.
7. 張繼剛.P16、CyclinD1在外陰鱗狀上皮增生和外陰鱗癌中的表達及意義[J]. 西北國防醫學雜志,2007,28(5):361-363.

West China Medical Journal

The Expression and Significances of Cyclind1,P16 in Cutaneous Squamous Carcinoma

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