Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis_West China Medical Journal

Authors：

1West China Hospital, Sichuan University; 2the Orthopedic Hospital of Sichuan Province, Chengdu 610041, China;

Corresponding?author：

Keywords：

雙醋瑞因; 鹽酸氨基葡萄糖; 雙氯芬酸鈉; 骨性關節炎

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:研究雙醋瑞因聯合鹽酸氨基葡萄糖和雙氯芬酸鈉治療骨性關節炎的可行性及安全性。方法:選取100例骨性關節炎患者,隨機分入雙醋瑞因組聯合雙氯芬酸鈉組(A組)、鹽酸氨基葡萄糖聯合雙氯芬酸鈉組(B組)、單用雙氯芬酸鈉組(C組)和雙醋瑞因組聯合雙氯芬酸鈉和鹽酸氨基葡萄糖組(D組)四組中,用藥12周后觀察治療前后臨床療效和綜合療效評分。結果:1.四組治療方案在VAS評分、關節疼痛度評分方面均有良好改善率;2D組治療方案優于A、B、C三組。結論:雙醋瑞因聯合鹽酸氨基葡萄糖和雙氯芬酸鈉治療骨性關節炎是可行、安全、優效的方案。

Citation： LI Min,YANG Nanping,WEI Hao,et al.. Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis. West China Medical Journal, 2009, 24(8): 2067-2069. doi: Copy

1.	唐福林,張奉春,鄭文潔,等.雙醋瑞因治療膝骨關節炎的療效與安全性多中心對照研究[J].中華風濕病學雜志,2005,9(7):421-422.
2.	胥方元,楊南萍,謝其冰,等.白芍總苷與奈丁美酮治療老年膝骨關節炎的比較[J].華西醫學,2006,21(1):57-58.
3.	YARON M, SHIRAZI I, YARON I. Antiinterleukin1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures[J]. Osteoarthritis Cartilage,1999,7(3):272-280.
4.	DOMAGALA F, MARTIN G, BOGDANOWICZ P, et al. Inhibition of interleukin1 βinduced activation of MEK/ERK pathway and DNA binding of NFκ B and AP1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology,2006,43 (3-4):577-587.
5.	FELISAZN, BOUMEDIENE K, GHAYOR C, et al. Stimulating effect of diacerein on TGFβ1 and β2 expression in articular chondrocytes cultured with and without interleukin1[J]. Osteoarthritis Cartilage,1999,7(3):255-264.
6.	TAMURA T, KOSAKA N, ISHIWA J, et al. Rhein, an active metabolite of diacerein, downregulates the production of promatrix metalloproteinases1, 3, 9 and 13 and upregulates the production of tissue inhibitor of metalloproteinase1 in cultured rabbit articular chondrocytes[J]. Osteoarthritis Cartilage,2001,9(3):257-263.
7.	DOUGADOSM, NGUYEN M, BERDAH L, et al. Evaluation of the structuremodifying effects of diacerin in hip osteoarthritis: ECHODIAH, a threeyear, placebocontrolled trial[J]. Arthritis Rheum,2001,44(11):2539-2547.

1. 唐福林,張奉春,鄭文潔,等.雙醋瑞因治療膝骨關節炎的療效與安全性多中心對照研究[J].中華風濕病學雜志,2005,9(7):421-422.
2. 胥方元,楊南萍,謝其冰,等.白芍總苷與奈丁美酮治療老年膝骨關節炎的比較[J].華西醫學,2006,21(1):57-58.
3. YARON M, SHIRAZI I, YARON I. Antiinterleukin1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures[J]. Osteoarthritis Cartilage,1999,7(3):272-280.
4. DOMAGALA F, MARTIN G, BOGDANOWICZ P, et al. Inhibition of interleukin1 βinduced activation of MEK/ERK pathway and DNA binding of NFκ B and AP1: potential mechanism for Diacerein effects in osteoarthritis[J]. Biorheology,2006,43 (3-4):577-587.
5. FELISAZN, BOUMEDIENE K, GHAYOR C, et al. Stimulating effect of diacerein on TGFβ1 and β2 expression in articular chondrocytes cultured with and without interleukin1[J]. Osteoarthritis Cartilage,1999,7(3):255-264.
6. TAMURA T, KOSAKA N, ISHIWA J, et al. Rhein, an active metabolite of diacerein, downregulates the production of promatrix metalloproteinases1, 3, 9 and 13 and upregulates the production of tissue inhibitor of metalloproteinase1 in cultured rabbit articular chondrocytes[J]. Osteoarthritis Cartilage,2001,9(3):257-263.
7. DOUGADOSM, NGUYEN M, BERDAH L, et al. Evaluation of the structuremodifying effects of diacerin in hip osteoarthritis: ECHODIAH, a threeyear, placebocontrolled trial[J]. Arthritis Rheum,2001,44(11):2539-2547.

West China Medical Journal

Comparison of the efficacy of diacerein, Glucosamine Hydrochloride and Diclofenac in the Treatment of Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Format

Content