The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy_West China Medical Journal

Authors：

ZENG Yan ¹ , JIANG Jing ¹ , WANG Yu ²

1the Department of Gynecology, Chengdu Railway Central Hospital, Chengdu 610081; 2the Department of Sport Medcine, Chengdu Institute of Physical Education, Chengdu 610041, China;

Corresponding?author：

Keywords：

手術后疲勞綜合征; 缺氧預處理; 超氧化物歧化酶; 丙二醛

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目的:研究缺氧預處理對老年大鼠子宮及雙附件切除術后疲勞是否有改善作用,并通過對比觀察超氧化物歧化酶及丙二醛水平的變化,初步探討缺氧預處理的作用機制。方法:將老年大鼠分為空白對照組、對照組、缺氧預處理三組。空白對照組為假手術組,對照組為子宮及雙附件切除術組, 缺氧預處理組為缺氧預處理加子宮及雙附件切除術組。對比觀察缺氧預處理對大鼠體力活動及血清超氧化物歧化酶和丙二醛水平的影響。結果:空白對照組、對照組、缺氧預處理三組大鼠懸尾不動時間分別為:(21±3)s,(83±10)s,(44±5)s,各組間比較P lt;0.05。三組SOD活性分別為:(131.23±5.31)U/L,(36.12±9.68)U/L,(73.01±9.82)U/L,各組間比較P lt;0.05。三組MDA水平分別為:(9.78±1.26)μmol/L,(29.87±3.13)μmol/L,(15.98±2.21)μmol/L,各組間比較P lt;0.05。結論:缺氧預處理可提高老年大鼠的抗氧化能力,對老年大鼠子宮及雙附件切除術后疲勞綜合征有明顯的改善作用。

Citation： ZENG Yan,JIANG Jing,WANG Yu. The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy. West China Medical Journal, 2009, 24(8): 2095-2097. doi: Copy

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1. RUBIN G J, HOTOPF M. Systematic review and metaanalysis of interventions for postoperative fatigue[J]. Br J Surg,2002,89(8):971-984.
2. MURRY C E, JENNING R B, REIMER K A. Preconditioning with ischmia: a delay of cell injury in ischemic myocardium[J]. Circulation,1986,74(5):1124-1136.
3. CHRISTENSEN T, KEHLET H. Postoperative fatigue[J].World J Surg,1993,17(2):220-225.
4. SALMON P, HALL G M. A theory of postoperative fatigue[J]. J R Soc Med,1997,90(12):661-664.
5. TSUTUI H. Oxidative stress in heart failure: the role of mitochondria[J]. Intern Med,2001,40 (12): 1177-1182.
6. CHANDRA M, SURENDRA K, KAPOOR R K, et al. Oxidant stress mechanisms in heart failure[J]. Boll Chim Farm,2000,139(3):149-152.
7. GLOSLI H, TRONSTAD K J, WERGEDAL H, et al. Human TNFα in transgenic mice induces differential changes in redox status and glutathioneregulating enzymes[J]. FASEB J,2002,16(11):1450-1452.
8. MALAPLATEARMAND C, GUEGUEN Y, BERTRAND P, et al. U373MG response to interleukin1βinduced oxidative stress[J]. Cell Biol Toxicol,2000,16(3):155-163.
9. IHNKEN K, WINKLERA, SCHLENSAK C, et al. Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult[J]. J Thorac Cardiovasc Surg,1998,116(2):327-334.

West China Medical Journal

The Effect of Hypoxic Preconditioning on Old Rat Model of Postoperative Fatigue Syndrome Caused by Excision of Bilateral Accessory and Hysterectomy

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