Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol_West China Medical Journal

Authors：

1Nong Jiu Shi Hospital, Xinjiang Army, Emin Xinjiang 834601; 2 Department of Neurology, Jiangyou People’s Hospital, Jiangyou Sichuan 621700; 3Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

普羅布考; 腦梗死; 高脂血癥; 心腦血管病

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目的:探討普羅布考對動脈粥樣硬化性腦梗死并高脂血癥患者血脂及預后的影響。方法:將87例腦梗死并高脂血癥患者隨機分為兩組,治療組44例,對照組43例,兩組除按動脈粥樣硬化性腦梗死常規治療外,停用一切降脂藥物。治療組給予普羅布考500mg bid/d。療程為6個月。隨訪一年觀察兩組患者治療后血脂水平及腦血管事件發生情況。結果:治療組患者治療前、后總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)間差異均有顯著性意義(P lt;0.05)。兩組患者治療后各項血脂指標間差異均有顯著性意義(P lt;0.05)。隨訪一年,顯示治療組患者心腦血管事件14次,對照組19次(P lt;0.05)。結論:普羅布考降脂療效可靠、副作用輕微,降低心腦血管事件發生。可作為動脈粥樣硬化性腦梗死并高脂血癥患者的一、二級預防藥物。

Citation： XIAO Weijun,ZHANG Hao,XU Pingrong.. Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol. West China Medical Journal, 2009, 24(9): 2234-2236. doi: Copy

1.	YOKOYAMA T, MIYAUCHI K, KURATA T. Effect of probucol on neointimal thickening in a stent porcine restenosis model[J]. Jpn Heart J, 2004, 45(2):305-13.
2.	賈偉華,周立春,田桂林. 普羅布考對頸動脈粥樣硬化斑塊穩定性影響的臨床研究[J].中國新藥雜志, 2007,16:237-239.
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4.	JEON SM, PARK YB, KWON OS, et al. Vitamin E supplementation alters HDLcholesterol concentration and paraoxonase activity in rabbits fed highcholesterol diet: comparison with probucol[J]. J Biochem Mol Toxicol, 2005, 19(5):336-46.
5.	HONG SC, ZHAO SP, WU ZH. Effect of probucol on HDL metabolism and class B type I scavenger receptor (SRBI) expression in the liver of hypercholesterolemic rabbits[J]. Int J Cardiol, 2007, 115(1):29-35.
6.	傅琛,夏強,曹春梅,等.活性氧,NO和線粒體ATP敏感鉀通道在TNF2A預處理對缺血/再灌注心肌保護中的作用[J].中國應用生理學雜志,2005,21(1):20-24.
7.	HONG SC, ZHAO SP, WU ZH.Probucol upregulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits[J]. J Cardiovasc Pharmacol, 2006, 47(1):77-81.
8.	顧江濤,屈文昌,張安,丙丁酚對冠心病及其高位人群血管內皮功能失調的作用[J].臨床心血管病雜志, 2006,22(2):117-118.
9.	FRUEBIS J, SILVESTRE M, SHELTON D, et al. Inhibition of VCAM1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits[J]. J Lipid Res, 1999, 40(11):1958-66.
10.	ADLOUNI A, EL MESSAL M, SA?LE R. Probucol promotes reverse cholesterol transport in heterozygous familial hypercholesterolemia. Effects on apolipoprotein AIcontaining lipoprotein particles[J]. Atherosclerosis, 2000,152(2):433-40.
11.	SUKHOVA GK, SCH?NBECK U, RABKIN E. Evidence for increased collagenolysis by interstitial collagenases1 and 3 in vulnerable human atheromatous plaques[J]. Circulation, 1999,18; 99(19):2503-9.

1. YOKOYAMA T, MIYAUCHI K, KURATA T. Effect of probucol on neointimal thickening in a stent porcine restenosis model[J]. Jpn Heart J, 2004, 45(2):305-13.
2. 賈偉華,周立春,田桂林. 普羅布考對頸動脈粥樣硬化斑塊穩定性影響的臨床研究[J].中國新藥雜志, 2007,16:237-239.
3. FORTI N, RAMIRES JA. Effects of lovastatin and probucol on lipoprotein fractions in patients with hypercholesterolemia. A Brazilian multicenter study[J]. Arq Bras Cardiol, 1991, 57(3):25361.
4. JEON SM, PARK YB, KWON OS, et al. Vitamin E supplementation alters HDLcholesterol concentration and paraoxonase activity in rabbits fed highcholesterol diet: comparison with probucol[J]. J Biochem Mol Toxicol, 2005, 19(5):336-46.
5. HONG SC, ZHAO SP, WU ZH. Effect of probucol on HDL metabolism and class B type I scavenger receptor (SRBI) expression in the liver of hypercholesterolemic rabbits[J]. Int J Cardiol, 2007, 115(1):29-35.
6. 傅琛,夏強,曹春梅,等.活性氧,NO和線粒體ATP敏感鉀通道在TNF2A預處理對缺血/再灌注心肌保護中的作用[J].中國應用生理學雜志,2005,21(1):20-24.
7. HONG SC, ZHAO SP, WU ZH.Probucol upregulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits[J]. J Cardiovasc Pharmacol, 2006, 47(1):77-81.
8. 顧江濤,屈文昌,張安,丙丁酚對冠心病及其高位人群血管內皮功能失調的作用[J].臨床心血管病雜志, 2006,22(2):117-118.
9. FRUEBIS J, SILVESTRE M, SHELTON D, et al. Inhibition of VCAM1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits[J]. J Lipid Res, 1999, 40(11):1958-66.
10. ADLOUNI A, EL MESSAL M, SA?LE R. Probucol promotes reverse cholesterol transport in heterozygous familial hypercholesterolemia. Effects on apolipoprotein AIcontaining lipoprotein particles[J]. Atherosclerosis, 2000,152(2):433-40.
11. SUKHOVA GK, SCH?NBECK U, RABKIN E. Evidence for increased collagenolysis by interstitial collagenases1 and 3 in vulnerable human atheromatous plaques[J]. Circulation, 1999,18; 99(19):2503-9.

West China Medical Journal

Clinical Investigation on Treating Arteriosclerotic Cerebral Infarction Combined with Hyperlipemia by Prubucol

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