Clinical Observation of the Thymosin α1 on the Immunotherapy in Severe Pneumonia_West China Medical Journal

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Department of Respiratory Medicine,the Third People’S Hospital of Chengdu City, Chengdu Sichuan 610031,China;

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Keywords：

胸腺肽α1; 免疫治療; 細胞因子; 重癥肺炎

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目的:探討胸腺肽α1(Tα1)對重癥肺炎細胞因子及免疫功能的影響,觀察Tα1在重癥肺炎中的治療作用。方法:將2005年3月至2007年12月在成都市第三人民醫院呼吸科(包括RICU)收治的重癥肺炎患者隨機分為對照組(40例)及用藥組(45例),在控制感染的基礎上加用胸腺肽α1,觀察細胞因子水平的變化及T細胞亞群的改變,同時觀察臨床癥狀、體征、X線改變,進行療效評價。結果:兩組患者腫瘤壞死因子(TNF-α),白細胞介素6(L-6)水平均呈升高趨勢,但對照組升高更加明顯,而白介素10(L-10)在用藥組患者中呈升高趨勢,治療第4,第8天,用藥組CD4+、CD4+/CD8+較用藥前升高,明顯高于對照組;治療組臨床療效及住院時間也優于對照組。結論:Tα1可以調節重癥肺炎患者的TNF-α,L-6,L-10等細胞因子的水平,減輕炎癥反應,改善患者的免疫功能。

Citation： WANG Xiaoxia,BAO Yong,LIAN Xiangzhong,et al.. Clinical Observation of the Thymosin α1 on the Immunotherapy in Severe Pneumonia. West China Medical Journal, 2009, 24(9): 2326-2328. doi: Copy

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6.	李朝芝,夏瑗瑜,李相友.胸腺肽α1對多器官功能衰竭合并嚴重感染患者細胞因子的影響[J].臨床內科雜志,2005,22:487-489.
7.	李承紅,王傳海,孟慶華等,胸腺肽α1對老年慢性阻塞性肺疾病急性發作期免疫功能的影響[J].中國醫院藥學雜志,2007,27(5):637-639.
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1. IAHOREC R.Ratio of neutrophil to lymphpcyto counts rapid and simple parameter of systemic inflammation and stress in critically ill[J].Br Lek Listy,2001,102:5-14.
2. 姜軍,李寧,黎介壽.胸腺肽α1對嚴重腹腔感染大鼠蛋白質代謝和細胞因子的影響[J].腸外與腸內營養,2005,12:165-169.
3. GROSSMAN RF,CAMPHELL DA,LANDIS SJ,et al. Treatment of communityacquired Pneumonia in the elderly:The role of cefepime,a fourthgeneration cephalosporin[J].J Antimicrob chemother,1999,43:549-554.
4. 胡曉磊,趙允召,于寶軍,等.胸腺肽α1對嚴重外科感染病人免疫功能和細胞因子的影響[J]. 中國實用外科雜志,2007,27(7):555-557.
5. LI CL,ZHANG T,SAIBARA T, et al. Thymosin α 1 accelerates restoration of T cellmediated eutralizing antibody response in immunocompromised hosts[J]. Int Immunophamacol,2002,2(1):39-46.
6. 李朝芝,夏瑗瑜,李相友.胸腺肽α1對多器官功能衰竭合并嚴重感染患者細胞因子的影響[J].臨床內科雜志,2005,22:487-489.
7. 李承紅,王傳海,孟慶華等,胸腺肽α1對老年慢性阻塞性肺疾病急性發作期免疫功能的影響[J].中國醫院藥學雜志,2007,27(5):637-639.
8. 候立群,熊利澤,尚磊,等.胸腺肽α1對重癥肺部感染患者T淋巴細胞亞群比例的影響[J].中華麻醉學雜志,2006,26(11):1005-1007.

West China Medical Journal

Clinical Observation of the Thymosin α1 on the Immunotherapy in Severe Pneumonia

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