Clinical Observation on Treatment by Docetaxel for the Joint Topotecan in Advanced Gastric Carcinoma_West China Medical Journal

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Department of Oncology,the People’s Hospital of Guangan Sity, Guangan sichuan 638000,China;

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Keywords：

晚期胃癌; 化學治療; 多西他賽; 拓撲替康

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目的:評價多西他賽(D)聯合拓撲替康(T)治療晚期胃癌的臨床療效和毒性反應。方法:用DT方案治療晚期胃痛患者47例。結果:可評價療效者47例,完全緩解(CR)4例,占8.5％:部分緩解(PR)28例,占59.6％:穩定(SD)11例．占23.4％:進展(PD)4例,占8.5％。總有效率:(CR+PR)為68.1％,臨床獲益率(CR+PR+SD)為91.5％。中位腫瘤進展期(TTP)8.4個月,中位生存期(MST)12.8個月。主要不良反應為骨髓抑制、白細胞減少、胃腸道反應、惡心嘔吐、腹瀉、口腔粘膜炎,無治療相關性死亡病例。結論:多西他賽聯合拓撲替康治療晚期胃癌臨床緩解率頗高,提高了生存質量,不良反應可耐受,患者治療依從性好,可以作為晚期胃癌一線治療方案。

Citation： WANG Xingyuan,JIANG Bo,LI Cheng. Clinical Observation on Treatment by Docetaxel for the Joint Topotecan in Advanced Gastric Carcinoma. West China Medical Journal, 2009, 24(9): 2336-2337. doi: Copy

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West China Medical Journal

Clinical Observation on Treatment by Docetaxel for the Joint Topotecan in Advanced Gastric Carcinoma

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