The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning_West China Medical Journal

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Department of Emergency, Affilicated Hospital of North Sichuan Medical College,Nancong Sichuan 637000,China;

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Keywords：

內皮素; 百草枯; 中毒

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目的:觀察百草枯中毒大鼠血漿和肺組織勻漿中的內皮素-1的動態變化,探討大鼠PQ中毒肺損傷的可能機制。方法:將雄性Wistar大鼠隨機分成百草枯中毒組和生理鹽水對照組,分別給予16mg/kg百草枯或等體積生理鹽水腹腔內注射,并在給藥后6、12、24和72 h處死大鼠,觀察其一般表現、肺的病理變化。測定肺系數、肺組織勻漿和血漿中內皮素-1的含量。結果: 百草枯中毒后大鼠出現呼吸困難,活動能力下降,肺系數增加,并隨時間變化,光鏡下表現為肺出血、水腫等不同程度的肺損傷改變。血漿和組織勻漿中內皮素-1在中毒后與對照組大鼠比較明顯升高,并隨時間變化(P lt;0.01)。結論:在百草枯中毒肺損傷中,內皮素-1可能發揮了重要作用。

Citation： LIU Shiping,HE Qing.. The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning. West China Medical Journal, 2009, 24(9): 2338-2340. doi: Copy

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West China Medical Journal

The Mechanisms of Endothelin-1 in Rat Paraquat Poisoning

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