• 1.Center of experiment and Technigue Chengdu medical college;2.Department of Pharmacy, General Hospital of Chengdu Military Region Chengdu Sichuan 610083, China;
復方氯唑沙宗; 藥物動力學; HPLCcomplex chlorzoxazone; pharmacokinetics; HPLC
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摘要:目的:建立測定復方氯唑沙宗片中氯唑沙宗血藥濃度的方法,并進行其在健康人體藥物動力學研究。方法:18名男性健康志愿者單劑量口服復方氯唑沙宗片,高效液相色譜法測定復方氯唑沙宗中氯唑沙宗的血藥濃度。結果和結論:此法操作簡便、結果可靠。復方氯唑沙宗片中的氯唑沙宗主要藥物動力學參數分別為T1/2 （0927±03747） h,Tmax （1403±0681） h,Cmax （21063±5748） mg/L,AUC0~6 （51624±15202） mg/(L·h),AUC0~ （53201±15142） mg/(L·h)。
Abstract: Objective: Aim To investigate the pharmacokinetics of complex chlorzoxazone tablets in healthy volunteers.Methods:Eighteen male healthy subjects received a single dose of two pieces of complex chlorzoxazone tablets.The concentration of complex chlorzoxazone was determined by HPLC.Results and Conclusion: This study provided a simple and reliable assay which can be used to determine two component concentrations of complex chlorzoxazone tablets in human serum. The main pharmacokinetic parameters of chlorzoxazone was as follows:T1/2 （0927±03747）h,Tmax （1403±0681）h,Cmax （21063±5748） mg/L,AUC0~6 （51624±15202） mg/(L·h),AUC0~5 （3201±15142） mg/(L·h).

Citation： LIANG Nan,JIANG Yunping.. Investigation of the Pharmacokinetics of Complex Chlorzoxazone Tablets in Healthy Volunteers. West China Medical Journal, 2009, 24(11): 2921-2923. doi: Copy

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