目的 探討肝臟局灶性結節性增生(FNH)的臨床診斷與治療,以提高對FNH的認識。
方法 回顧性分析我院普通外科2004年7月至2011年7月期間收治的21例經術后病理證實為FNH的臨床資料。
結果 本組21例FNH患者中男6例,女15例,平均年齡31.1歲。單發19例,多發2例。9例為體檢發現,無不適癥狀;12例有右上腹隱痛不適癥狀,均無肝炎、肝硬變病史;1例女性患者有長期口服雌激素病史。化驗檢查:谷丙轉氨酶輕度升高1例,其余肝功能檢查、腫瘤標志物及HBsAg均為陰性。術前影像學檢查診斷符合率:彩超檢查為42.9% (6/14),CT檢查為50.0% (6/12),MRI檢查為38.5% (5/13)。術后均恢復良好,隨訪至今無復發。
結論 FNH術前確診率仍較低,主要依賴術后病理學檢查。對于術前診斷不明確、病灶巨大或有臨床癥狀者仍應采取手術切除治療。
Citation:
賈昌俊,戴朝六,卜獻民,彭松林,徐鋒,許永慶,趙陽. Diagnosis and Treatment for Hepatic Focal Nodular Hyperplasia (Report of 21 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(5): 553-554. doi:
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Bosman FT, Carneiro F, Hruban RH, et al. World Health Organi-zation classification of tumours of the digestive system[M]. 4th ed.lyon:Iarc Press, 2010:198-204.
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Hussain SM, Terkivatan T, Zondervan PE, et al. Focal nodular hyperplasia:findings at state-of-the-art MR imaging, US, CT, and pathologic analysis[J]. Radiographics, 2004, 24(1):3-17.
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李迎春, 宋彬, 蔣莉莉, 等. 新型MR造影劑釓貝葡胺診斷肝臟局灶性結節樣增生的價值(附5例報告)[J]. 中國普外基礎與臨床雜志, 2007, 14(5):598-604.
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Langrehr JM, Pfitzmann R, Hermann M, et al. Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia[J]. Acta Radiol, 2006, 47(4):340-344.
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- 1. Bosman FT, Carneiro F, Hruban RH, et al. World Health Organi-zation classification of tumours of the digestive system[M]. 4th ed.lyon:Iarc Press, 2010:198-204.
- 2. 陳伶俐, 紀元, 許建芳, 等. 肝臟局灶結節性增生238例臨床病理分析[J]. 中華病理學雜志, 2011, 40(1):17-22.
- 3. 王征旭, 胡桂芳, 吳孟超. 肝臟局灶性結節增生的診斷和治療(附21例報告)[J]. 中國普外基礎與臨床雜志, 2003, 10(2):147-150.
- 4. Cong WM, Dong H, Tan L, et al. Surgicopathological classification of hepatic space-occupying lesions:a single-center experience with literature review[J]. World J Gastroenterol, 2011, 17(19):2372-2378.
- 5. Kapp N, Curtis KM. Hormonal contraceptive use among women with liver tumors:a systematic review[J]. Contraception, 2009, 80(4):387-390.
- 6. Hussain SM, Terkivatan T, Zondervan PE, et al. Focal nodular hyperplasia:findings at state-of-the-art MR imaging, US, CT, and pathologic analysis[J]. Radiographics, 2004, 24(1):3-17.
- 7. 李迎春, 宋彬, 蔣莉莉, 等. 新型MR造影劑釓貝葡胺診斷肝臟局灶性結節樣增生的價值(附5例報告)[J]. 中國普外基礎與臨床雜志, 2007, 14(5):598-604.
- 8. Rahili A, Cai J, Trastour C, et al. Spontaneous rupture andhemorrhage of hepatic focal nodular hyperplasia in lobus caudatus[J]. J Hepatobiliary Pancreat Surg, 2005, 12(2):138-142.
- 9. Langrehr JM, Pfitzmann R, Hermann M, et al. Hepatocellular carcinoma in association with hepatic focal nodular hyperplasia[J]. Acta Radiol, 2006, 47(4):340-344.