Insulinoma: Imaging Features and Correlation with Pathological Findings (Analysis of 8 Cases)_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Xie ^1,2 , TU Yuan ³ , HUANG Zixing ¹ , SONG Bin ¹ , ZHONG Huanhuan ¹ , ZHAO Shuang ¹

1.Department of Radiology， West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;;
2.Department of Radiology, Chengdu No.2 People’s Hospital, Chengdu 610017, Sichuan Province, China;;
3.Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;

Corresponding?author：

Keywords：

Pancreas neoplasm; Insulinoma; Tomography; X-ray computed; Magnetic resonance imaging

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ObjectiveTo investigate the imaging features of insulinoma on multi-slice spiral CT (MSCT) and magnetic resonance imaging (MRI) with correlation of pathology. MethodsAll images of 8 patients confirmed by surgery and pathology were retrospectively analyzed with correlation of pathology. MSCT scans were performed in 4 patients and MR scans in 6 patients, among which 2 patients accepted both MSCT and MRI examinations. ResultsInsulinoma in all patients manifested as solitary lesions with diameters of 0.5-3.5 cm. Four lesions demonstrated isodensity or hypodensity on plain MSCT, with significant enhancement on arterial phase, and relative isodensity or slight hyperdensity on portal phase and delay phase. On plain MRI, lesions demonstrated hyperintensity on T1WI, slight hyperintensity or hyperintensity on T2WI. The enhanced patterns of insulinoma were similar to the findings on MSCT. ConclusionsThe imaging characteristics of insulinoma reflect the pathological features. MSCT and MRI are effective in the diagnosis of inslinoma, and MRI can show more diagnostic information.

Citation： ZHANG Xie ,TU Yuan,HUANG Zixing,SONG Bin,ZHONG Huanhuan,ZHAO Shuang. Insulinoma: Imaging Features and Correlation with Pathological Findings (Analysis of 8 Cases). CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(3): 336-340. doi: Copy

1.	Berends FJ, Cuesta MA, Kazemier G, et al. Laparoscopic detection and resection of insulinomas [J]. Surgery, 2000, 128(3): 386391.
2.	Stark DD, Moss AA, Goldberg HI, et al. CT of pancreatic islet cell tumors [J]. Radiology, 1984, 150(2): 491494.
3.	Gualdi GF, Casciani E, Polettini E. Imaging of neuroendocrine tumors [J]. Clin Ter, 2001, 152(2): 107121.
4.	權毅, 嚴律南. 胰島素瘤的診斷和治療(附15例報告) [J]. 中國普外基礎與臨床雜志, 2000, 7(6): 364366.
5.	高鵬, 王正娥, 周艷貞. 胰島素瘤的診斷和治療(附25例報告) [J]. 中國普外基礎與臨床雜志, 1999, 6(6): 357358.
6.	Shin JJ, Gorden P, Libutti SK. Insulinoma: pathophysiology, localization and management [J]. Future Oncol, 2010, 6(2): 229237.
7.	Ehehalt F, Saeger HD, Schmidt CM, et al. Neuroendocrine tumors of the pancreas [J]. Oncologist, 2009, 14(5): 456467.
8.	Rockall AG, Reznek RH. Imaging of neuroendocrine tumours (CT/MR/US) [J]. Best Pract Res Clin Endocrinol Metab, 2007, 21(1): 4368.
9.	Rothmund M, Angelini L, Brunt M, et al. Surgery for benign insulinoma: an international reviews [J]. World J Surg, 1990, 14(3): 393398.
10.	Bottger TC, Weber W, Beyer J, et al. Value of tumors localization in patients with insulinoma [J]. World J Surg, 1990, 14(1): 107112.
11.	McAuley G, Delaney H, Colville J, et al. Multimodality preoperative imaging of pancreatic insulinomas [J]. Clin Radiol, 2005, 60(10): 10391050.
12.	Sun MR, Brennan DD, Kruskal JB, et al. Intraoperative ultrasonography of the pancreas [J]. Radiographics, 2010, 30(7): 19351953.
13.	李俊來, 董寶瑋, 唐杰, 等. 術中超聲在胰島素瘤定位診斷中的價值 [J]. 中華超聲影像學雜志, 2000, 9(6): 340342.
14.	于曉玲, 梁萍, 董寶瑋, 等. 超聲造影診斷胰腺局灶性病變的價值 [J]. 中國醫學影像學雜志, 2008, 16(3): 170173.
15.	D’Onofrio M, Zamboni G, Tognolini A, et al. Massforming pancreatitis: value of contrastenhanced ultrasonography [J]. World J Gastroenterol, 2006, 12(26): 41814184.
16.	Sofuni A, Iijima H, Moriyasu F, et al. Differential diagnosis of pancreatic tumors using ultrasound contrast imaging [J]. J Gastroenterol, 2005, 40(5): 518525.
17.	Ichikawa T, Peterson MS, Federle MP, et al. Islet cell tumor of the pancreas: biphasic CT versus MR imaging in tumor detection [J]. Radiology, 2000, 216(1): 163171.
18.	Jyotsna VP, Rangel N, Pal S, et al. Insulinoma: diagnosis and surgical treatment. Retrospective analysis of 31 cases [J]. Indian J Gastroenterol, 2006, 25(5): 244247.
19.	StaffordJohnson DB, Francis IR, Eckhauser FE, et al. Dualphase helical CT of nonfunctioning islet cell tumors [J]. J Comput Assist Tomogr, 1998, 22(1): 335339.
20.	Sheth S, Hruban RK, Fishman EK. Helical CT of islet cell tumors of the pancreas: typical and atypical manifestations [J]. AJR Am J Roentgenol, 2002, 179(3): 725730.
21.	龍學穎, 李宜雄, 王憲偉, 等. 胰島素瘤術前CT定位診斷的回顧性分析 [J]. 中南大學學報(醫學版), 2009, 34(2): 165171.
22.	孫春峰, 吳志遠, 陸健, 等. 螺旋CT三期增強掃描在小胰島細胞瘤(直徑≤2 cm)診斷中的價值 [J]. 臨床放射學雜志, 2010, 29(5): 624628．.
23.	李傳福, 張紅蕾, 劉松濤, 等. 胰島素瘤的MRI診斷 [J]. 中華放射學雜志, 2001, 35(2): 99102.
24.	Thoeni RF, Mueller Lisse UG, Chan R, et al. Detection of small, functional islet cell tumors in the pancreas: selection of MR imaging sequences for optimal sensitivity [J]. Radiology, 2000, 214(2): 483490.
25.	Anaye A, Mathieu A, Closset J, et al. Successful preoperative localization of a small pancreatic insulinoma by diffusionweighted MRI [J]. JOP, 2009, 10(5): 528531.
26.	宋彬, 徐雋, 閔鵬秋. 胰腺的血管系統 [J]. 中國醫學計算機成像雜志, 2002, 8(4): 217222.

1. Berends FJ, Cuesta MA, Kazemier G, et al. Laparoscopic detection and resection of insulinomas [J]. Surgery, 2000, 128(3): 386391.
2. Stark DD, Moss AA, Goldberg HI, et al. CT of pancreatic islet cell tumors [J]. Radiology, 1984, 150(2): 491494.
3. Gualdi GF, Casciani E, Polettini E. Imaging of neuroendocrine tumors [J]. Clin Ter, 2001, 152(2): 107121.
4. 權毅, 嚴律南. 胰島素瘤的診斷和治療(附15例報告) [J]. 中國普外基礎與臨床雜志, 2000, 7(6): 364366.
5. 高鵬, 王正娥, 周艷貞. 胰島素瘤的診斷和治療(附25例報告) [J]. 中國普外基礎與臨床雜志, 1999, 6(6): 357358.
6. Shin JJ, Gorden P, Libutti SK. Insulinoma: pathophysiology, localization and management [J]. Future Oncol, 2010, 6(2): 229237.
7. Ehehalt F, Saeger HD, Schmidt CM, et al. Neuroendocrine tumors of the pancreas [J]. Oncologist, 2009, 14(5): 456467.
8. Rockall AG, Reznek RH. Imaging of neuroendocrine tumours (CT/MR/US) [J]. Best Pract Res Clin Endocrinol Metab, 2007, 21(1): 4368.
9. Rothmund M, Angelini L, Brunt M, et al. Surgery for benign insulinoma: an international reviews [J]. World J Surg, 1990, 14(3): 393398.
10. Bottger TC, Weber W, Beyer J, et al. Value of tumors localization in patients with insulinoma [J]. World J Surg, 1990, 14(1): 107112.
11. McAuley G, Delaney H, Colville J, et al. Multimodality preoperative imaging of pancreatic insulinomas [J]. Clin Radiol, 2005, 60(10): 10391050.
12. Sun MR, Brennan DD, Kruskal JB, et al. Intraoperative ultrasonography of the pancreas [J]. Radiographics, 2010, 30(7): 19351953.
13. 李俊來, 董寶瑋, 唐杰, 等. 術中超聲在胰島素瘤定位診斷中的價值 [J]. 中華超聲影像學雜志, 2000, 9(6): 340342.
14. 于曉玲, 梁萍, 董寶瑋, 等. 超聲造影診斷胰腺局灶性病變的價值 [J]. 中國醫學影像學雜志, 2008, 16(3): 170173.
15. D’Onofrio M, Zamboni G, Tognolini A, et al. Massforming pancreatitis: value of contrastenhanced ultrasonography [J]. World J Gastroenterol, 2006, 12(26): 41814184.
16. Sofuni A, Iijima H, Moriyasu F, et al. Differential diagnosis of pancreatic tumors using ultrasound contrast imaging [J]. J Gastroenterol, 2005, 40(5): 518525.
17. Ichikawa T, Peterson MS, Federle MP, et al. Islet cell tumor of the pancreas: biphasic CT versus MR imaging in tumor detection [J]. Radiology, 2000, 216(1): 163171.
18. Jyotsna VP, Rangel N, Pal S, et al. Insulinoma: diagnosis and surgical treatment. Retrospective analysis of 31 cases [J]. Indian J Gastroenterol, 2006, 25(5): 244247.
19. StaffordJohnson DB, Francis IR, Eckhauser FE, et al. Dualphase helical CT of nonfunctioning islet cell tumors [J]. J Comput Assist Tomogr, 1998, 22(1): 335339.
20. Sheth S, Hruban RK, Fishman EK. Helical CT of islet cell tumors of the pancreas: typical and atypical manifestations [J]. AJR Am J Roentgenol, 2002, 179(3): 725730.
21. 龍學穎, 李宜雄, 王憲偉, 等. 胰島素瘤術前CT定位診斷的回顧性分析 [J]. 中南大學學報(醫學版), 2009, 34(2): 165171.
22. 孫春峰, 吳志遠, 陸健, 等. 螺旋CT三期增強掃描在小胰島細胞瘤(直徑≤2 cm)診斷中的價值 [J]. 臨床放射學雜志, 2010, 29(5): 624628．.
23. 李傳福, 張紅蕾, 劉松濤, 等. 胰島素瘤的MRI診斷 [J]. 中華放射學雜志, 2001, 35(2): 99102.
24. Thoeni RF, Mueller Lisse UG, Chan R, et al. Detection of small, functional islet cell tumors in the pancreas: selection of MR imaging sequences for optimal sensitivity [J]. Radiology, 2000, 214(2): 483490.
25. Anaye A, Mathieu A, Closset J, et al. Successful preoperative localization of a small pancreatic insulinoma by diffusionweighted MRI [J]. JOP, 2009, 10(5): 528531.
26. 宋彬, 徐雋, 閔鵬秋. 胰腺的血管系統 [J]. 中國醫學計算機成像雜志, 2002, 8(4): 217222.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Insulinoma: Imaging Features and Correlation with Pathological Findings (Analysis of 8 Cases)

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