p120-Catenin━━A New Member of Catenin Family_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

NAN Runling ¹ , SHANG Peizhong ²

1.Hebei North University, Zhangjiakou 075000, Hebei Province, China;;
2.Department of General Surgery, The 251st Hospital of PLA, Zhangjiakou 075000, Hebei Province, China;

Corresponding?author：

Keywords：

p120-catenin; Cell adhesion; Malignant tumor

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo summarize the progress of p120-catenin (p120ctn)——a new member of catenin family in tumor research. MethodsDemestic and international published literatures related to p120ctn in recent years were collected and reviewed. Results① p120ctn was involved in formation of cadherincatenin complex, participated in cell growth, proliferation, and adheren junctions. ② p120ctn regulated Rho GTP activity and promoted cell motility. ③ p120ctn was involved in the regulation of gene transcription through binding with the nuclear transcription factor Kaiso. ④ p120ctn was involved in angiogenesis process induced by vascular endothelial growth factor. ⑤ p120ctn was involved in inflammation, cell malignant transformation, and tumor invasion and metastasis. ConclusionsAs a new member of catenin family, p120ctn participates in a variety of biological processes relying on its cellular localization. It will be facilitated to judge the genesis and progression of tumor from the abnormal alteration of p120ctn according to understanding the biological function and mechanism of p120ctn in the molecular level, a new pathway in the prevention and treatment of cancer is provided.

Citation： NAN Runling ,SHANG Peizhong. p120-Catenin━━A New Member of Catenin Family. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2011, 18(4): 462-467. doi: Copy

1.	Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropinreleasing hormone to promote tumor cell migration and invasion in ovarian cancer [J]. Oncogene, 2010, 29(16): 24272440.
2.	Albert B, Reynolds AB. p120catenin: Past and present [J]. Biochim Biophys Acta, 2007, 1773(1): 27.
3.	歐海玲, 覃宇周, 張錫流. Ecadherin/p120ctn與腫瘤關系的研究進展 [J]. 中國臨床新醫學, 2009, 2(2): 201205.
4.	Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
5.	Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
6.	Ishiyama N, Lee SH, Liu S, et al. Dynamic and static interactions between p120 catenin and Ecadherin regulate the stability of cellcell adhesion [J]. Cell, 2010, 141(1): 117128.
7.	Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
8.	SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
9.	Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
10.	Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
11.	Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
12.	Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
13.	Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
14.	Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
15.	Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
16.	Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
17.	Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
18.	Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
19.	Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
20.	羅小華, 劉文勵. P120ctn在血管內皮生長因子誘導血管生成中的作用 [J]. 臨床血液學雜志, 2006, 19(1): 5456.
21.	Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
22.	Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
23.	van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
24.	黃華藝, 農朝贊, 郭凌宵, 等. 肝癌細胞生物學行為改變涉及p120ctn酪氨酸磷酸化的研究 [J]. 中華醫學雜志, 2003, 83(20): 18011806.
25.	Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
26.	農朝贊, 黃嬋娟, 潘莉莉, 等. β連環蛋白在轉染p120ctn同工蛋白3A的肝癌細胞中的表達變化 [J]. 臨床與實驗病理學雜志, 2008, 24(6): 712715.
27.	Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
28.	張毅, 朱瑾, 楊占宇, 等. 連環蛋白P120在肝細胞癌中的表達及其意義 [J]. 消化外科, 2006, 5(6): 431434.
29.	Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
30.	Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
31.	Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
32.	虞志強. CDX2和p120catenin在胃癌組織中的臨床意義 [J]. 實用癌癥雜志, 2009, 24(6): 573575.
33.	Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer [J]. Biochim Biophys Acta, 2003, 1653(1): 124.
34.	戴越盟, 嚴律南. β連環蛋白及APC基因與腫瘤 [J]. 中國普外基礎與臨床雜志, 2002, 9(4): 291292.
35.	Yanagisawa M, Huveldt D, Kreinest P, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease [J]. J Biol Chem, 2008, 283(26): 1834418354.
36.	李景南, 李瀟, 錢家鳴, 等. Kras基因突變通過調節Ecadherin/βcatenin/p120蛋白復合體形成和RhoA蛋白活性對結腸癌細胞株Caco2轉移的影響 [J]. 中國醫學科學院學報, 2010, 32(1): 4650.
37.	Bellovin DI, Bates RC, Muzikansky A, et al. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease [J]. Cancer Res, 2005, 65(23): 1093810945.
38.	Verschuur EM, Siersema PD. Diagnostics and treatment of esophageal cancers [J]. Ned Tijdschr Tandheelkd, 2010, 117(9): 427431.
39.	Ma J, Zhang J, Ma Y, et al. Adenovirusmediated RhoA shRNA suppresses growth of esophageal squamous cell carcinoma cells in vitro and in vivo [J]. Med Oncol, 2010, [Epub ahead of print].
40.	Chung Y, Lam AK, Luk JM, et al. Altered Ecadherin expression and p120 catenin localization in esophageal squamous cell carcinoma [J]. Ann Surg Oncol, 2007, 14(11): 32603267.
41.	Wijnhoven BP, Pignatelli M, Dinjens WN, et al. Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction [J]. J Surg Oncol, 2005, 92(2): 116123.
42.	Miao Y, Liu N, Zhang Y, et al. p120ctn isoform 1 expression significantly correlates with abnormal expression of Ecadherin and poor survival of lung cancer patients [J]. Med Oncol, 2010, 27(3): 880886.
43.	Dai SD, Zhang XW, Qi FJ, et al. Expression of Ecadherin, betacatenin and p120ctn in the pulmonary sclerosing hemangioma [J]. Lung Cancer, 2007, 57(1): 5459.
44.	Wang EH, Liu Y, Xu HT, et al. Abnormal expression and clinicopathologic significance of p120catenin in lung cancer [J]. Histol Histopathol, 2006, 21(8): 841847.
45.	Liu Y, Wang Y, Zhang Y, et al. Abnormal expression of p120catenin, Ecadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer [J]. Lung Cancer, 2009, 63(3): 375382.
46.	苗原, 劉洋, 王妍, 等. p120ctn亞型在肺鱗癌、腺癌中表達及意義 [J]. 中國肺癌雜志, 2008, 11(2): 189193.
47.	Chu EA, Wu JM, Tunkel DE, et al. Nasopharyngeal carcinoma: the role of the EpsteinBarr virus [J]. Medscape J Med, 2008, 10(7): 165.
48.	Dittmer DP, Hilscher CJ, Gulley ML, et al. Multiple pathways for EpsteinBarr virus episome loss from nasopharyngeal carcinoma [J]. Int J Cancer, 2008, 123(9): 21052112.
49.	游淑源, 韓安家, 張芬芬, 等. 鼻咽癌中EB病毒編碼的潛伏膜蛋白1對βcatenin轉錄活性及表達的影響 [J]. 中華病理學雜志, 2010, 39(8): 537541.
50.	葉輝信, 張錫流, 歐海燕, 等. 上皮鈣黏蛋白和連環蛋白120在鼻咽癌組織中的表達及相關性研究 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2009, 23(14): 646648.
51.	歐海玲, 覃宇周, 張錫流, 等. P120連環蛋白在鼻咽癌中的表達及其與細胞凋亡的關系 [J]. 實用醫學雜志, 2009, 25(22): 37493752.
52.	Zhang X, Disanto ME. Rhokinase, a common final path of various contractile bladder and ureter stimuli [J]. Handb Exp Pharmacol, 2011, (202): 543568.
53.	Mandeville JA, Silva Neto B, Vanni AJ, et al. Pcadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells [J]. BJU Int, 2008, 2(11): 17071714.
54.	林成楚, 許恩賜. 膀胱移行細胞癌中p120ctn的表達及意義 [J]. 山東醫藥, 2008, 48(30): 3637.
55.	Silva Neto B, Smith GL, Mandeville JA, et al. Prognostic significance of altered p120 ctn expression in bladder cancer [J]. BJU Int, 2008, 101(6): 746752.
56.	張錫流, 何仕遠, 張力, 等． E鈣黏附蛋白及其相關蛋白在前列腺癌組織中的表達及其臨床意義 [J]. 檢驗醫學, 2006, 21(1): 57.
57.	Kaulfuss S, von Hardenberg S, Schweyer S, et al. Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression [J]. Oncogene, 2009, 28(45): 39713982.
58.	van Oort IM, Tomita K, van Bokhoven A, et al. The prognostic value of Ecadherin and the cadherinassociated molecules alpha, beta, gammacatenin and p120ctn in prostate cancer specific survival: a longterm followup study [J]. Prostate, 2007, 67(13): 14321438.
59.	Kallakury BV, Sheehan CE, WinnDeen E, et al. Decreased expression of catenins (alpha and beta), p120 CTN, and Ecadherin cell adhesion proteins and Ecadherin gene promoter methylation in prostatic adenocarcinomas [J]. Cancer, 2001, 92(11): 27862795.
60.	Freeman JW, McGrath P, Bondada V, et al. Prognostic significance of proliferation associated nucleolar antigen p120 in human breast carcinoma [J].Cancer Res, 1991, 51(8): 19731978.
61.	Paredes J, Correia AL, Ribeiro AS, et al. Expression of p120catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines [J]. Cell Oncol, 2007, 29(6): 467476.
62.	Sarrió D, PérezMies B, Hardisson D, et al. Cytoplasmic localization of p120ctn and Ecadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions [J]. Oncogene, 2004, 23(19): 32723283.
63.	Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin [J]. Am J Surg Pathol, 2007, 31(3): 427437.
64.	李曉鳴, 溫漓潮, 朱任之. 乳腺典型髓樣癌與非典型髓樣癌生物學行為差異的研究 [J]. 中國普外基礎與臨床雜志, 2003, 10(3): 268269.
65.	Boriani S, Bandiera S, Biagini R, et al. Chordoma of the mobilesp ine: fifty years of experience [J]. Spine (Phila Pa 1976), 2006, 31(4): 493503.
66.	Guirat A, Affes N, Boujlbene S, et al. Sacral chordoma: a rare tumor of the buttocks [J]. Ann Dermatol Venereol, 2009, 136(67): 526529.
67.	Schwab JH, Boland PJ, Agaram NP, et al. Chordoma and chondrosarcoma gene profile: implications for immunotherapy [J]. Cancer Immunol Immunother, 2009, 58(3): 339349.
68.	馬俊明, 楊興海, 黃權, 等. Ecadherin和P120ctn在脊柱脊索瘤中的異常表達 [J]. 脊柱外科雜志, 2009, 7(4): 193197.
69.	Chartier NT, Oddou CI, Lainé MG, et al. Cyclindependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)dependent cell growth control: a new role for p120ctn in cancer [J]. Cancer Res, 2007, 67(20): 97819790.

1. Cheung LW, Leung PC, Wong AS. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropinreleasing hormone to promote tumor cell migration and invasion in ovarian cancer [J]. Oncogene, 2010, 29(16): 24272440.
2. Albert B, Reynolds AB. p120catenin: Past and present [J]. Biochim Biophys Acta, 2007, 1773(1): 27.
3. 歐海玲, 覃宇周, 張錫流. Ecadherin/p120ctn與腫瘤關系的研究進展 [J]. 中國臨床新醫學, 2009, 2(2): 201205.
4. Hatzfel DM. The p120 family of cell adhesion molecules [J]. Eur J Cell Biol, 2005, 84(23): 205214.
5. Grossmann KS, Grund C, Huelsken J, et al. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation [J]. J Cell Biol, 2004, 167(1): 149160.
6. Ishiyama N, Lee SH, Liu S, et al. Dynamic and static interactions between p120 catenin and Ecadherin regulate the stability of cellcell adhesion [J]. Cell, 2010, 141(1): 117128.
7. Xiao K, Oas RG, Chiasson CM, et al. Role of p120catenin in cadherin trafficking [J]. Biochim Biophys Acta, 2007, 1773(1): 816.
8. SmalleyFreed WG, Efimov A, Burnett PE, et al. p120catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [J]. J Clin Invest, 2010, 120(6): 18241835.
9. Ichii T, Takeichi M. p120catenin regulates microtubule dynamics and cell migration in a cadherinindependent manner [J]. Genes Cells, 2007, 12(7): 827839.
10. Anastasiadis PZ. p120ctn: A nexus for contextual signaling via Rho GTPases [J]. Biochim Biophys Acta, 2007, 1773(1): 3446.
11. Kolanus W, Zeitlmann L. Regulation of integrin function by insideout signaling mechanisms [J]. Curr Top Microbiol Immunol, 1998, 231: 3349.
12. Fukumoto Y, Shintani Y, Reynolds AB, et al. The regulatory or phosphorylation domain of p120 catenin controls Ecadherin dynamics at the plasma membrane [J]. Exp Cell Res, 2008, 314(1): 5267.
13. Brown MV, Burnett PE, Denning MF, et al. PDGF receptor activation induces p120catenin phosphorylation at serine 879 via a PKCalphadependent pathway [J]. Exp Cell Res, 2009, 315(1): 3949.
14. Soto E, Yanagisawa M, Marlow LA, et al. p120 catenin induces opposing effects on tumor cell growth depending on Ecadherin expression [J]. J Cell Biol, 2008, 183(4): 737749.
15. Zhang J, O’Donnell JJ 3rd, Holian O, et al. P120 catenin represses transcriptional activity through Kaiso in endothelial cells [J]. Microvasc Res, 2010, 80(2): 233239.
16. Fukuyama T, Ogita H, Kawakatsu T, et al. Activation of Rac by cadherin through the cSrcRap1phosphatidylinositol 3kinaseVav2 pathway [J]. Oncogene, 2006, 25(1): 819.
17. Daniel JM. Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso [J]. Biochim Biophys Acta, 2007, 1773(1): 5968.
18. Park JI, Kim SW, Lyons JP, et al. Kaiso/p120catenin and TCF/betacatenin complexes coordinately regulate canonical Wnt gene targets [J]. Dev Cell, 2005, 8(6): 843854.
19. Dai SD, Wang Y, Jiang GY, et al. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn [J]. Lung Cancer, 2010, 67(2): 205215.
20. 羅小華, 劉文勵. P120ctn在血管內皮生長因子誘導血管生成中的作用 [J]. 臨床血液學雜志, 2006, 19(1): 5456.
21. Oas RG, Xiao K, Summers S, et al. p120Catenin is required for mouse vascular development [J]. Circ Res, 2010, 106(5): 941951.
22. Esser S, Lampugnani MG, Corada M, et al. Vascular endothelial growth factor induces VEcadherin tyrosine phosphorylation in endothelial cells [J]. J Cell Sci, 1998, 111(Pt 13): 18531865.
23. van Hengel J, van Roy F. Diverse functions of p120ctn in tumors [J]. Biochim Biophys Acta, 2007, 1773(1): 7888.
24. 黃華藝, 農朝贊, 郭凌宵, 等. 肝癌細胞生物學行為改變涉及p120ctn酪氨酸磷酸化的研究 [J]. 中華醫學雜志, 2003, 83(20): 18011806.
25. Nong CZ, Pan LL, He WS, et al. P120ctn overexpression enhances beta catenin Ecadherin binding and down regulates expression of survivin and cyclin D1 in BEL7404 hepatoma cells [J]. World J Gastroenterol, 2006, 12(8): 11871191.
26. 農朝贊, 黃嬋娟, 潘莉莉, 等. β連環蛋白在轉染p120ctn同工蛋白3A的肝癌細胞中的表達變化 [J]. 臨床與實驗病理學雜志, 2008, 24(6): 712715.
27. Zhai B, Yan HX, Liu SQ, et al. Reduced expression of Ecadherin/catenin complex in hepatocellular carcinomas [J]. World J Gastroenterol, 2008, 14(37): 56655673.
28. 張毅, 朱瑾, 楊占宇, 等. 連環蛋白P120在肝細胞癌中的表達及其意義 [J]. 消化外科, 2006, 5(6): 431434.
29. Karatzas G, Karayiannakis AJ, Syrigos KN, et al. Expression patterns of the Ecadherincatenin cellcell adhesion complex in gastric cancer [J]. Hepatogastroenterology, 2000, 47(35): 14651469.
30. Ogden SR, Wroblewski LE, Weydig C, et al. p120 and Kaiso regulate Helicobacter pyloriinduced expression of matrix metalloproteinase [J]. Mol Biol Cell, 2008,19(10): 41104121.
31. Jawhari AU, Noda M, Pignatelli M, et al. Upregulated cytoplasmic expression, with reduced membranous distribution, of the srcsubstrate p120 (ctn) in gastric carcinoma [J]. J Pathol, 1999, 189(2): 180185.
32. 虞志強. CDX2和p120catenin在胃癌組織中的臨床意義 [J]. 實用癌癥雜志, 2009, 24(6): 573575.
33. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer [J]. Biochim Biophys Acta, 2003, 1653(1): 124.
34. 戴越盟, 嚴律南. β連環蛋白及APC基因與腫瘤 [J]. 中國普外基礎與臨床雜志, 2002, 9(4): 291292.
35. Yanagisawa M, Huveldt D, Kreinest P, et al. A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease [J]. J Biol Chem, 2008, 283(26): 1834418354.
36. 李景南, 李瀟, 錢家鳴, 等. Kras基因突變通過調節Ecadherin/βcatenin/p120蛋白復合體形成和RhoA蛋白活性對結腸癌細胞株Caco2轉移的影響 [J]. 中國醫學科學院學報, 2010, 32(1): 4650.
37. Bellovin DI, Bates RC, Muzikansky A, et al. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease [J]. Cancer Res, 2005, 65(23): 1093810945.
38. Verschuur EM, Siersema PD. Diagnostics and treatment of esophageal cancers [J]. Ned Tijdschr Tandheelkd, 2010, 117(9): 427431.
39. Ma J, Zhang J, Ma Y, et al. Adenovirusmediated RhoA shRNA suppresses growth of esophageal squamous cell carcinoma cells in vitro and in vivo [J]. Med Oncol, 2010, [Epub ahead of print].
40. Chung Y, Lam AK, Luk JM, et al. Altered Ecadherin expression and p120 catenin localization in esophageal squamous cell carcinoma [J]. Ann Surg Oncol, 2007, 14(11): 32603267.
41. Wijnhoven BP, Pignatelli M, Dinjens WN, et al. Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction [J]. J Surg Oncol, 2005, 92(2): 116123.
42. Miao Y, Liu N, Zhang Y, et al. p120ctn isoform 1 expression significantly correlates with abnormal expression of Ecadherin and poor survival of lung cancer patients [J]. Med Oncol, 2010, 27(3): 880886.
43. Dai SD, Zhang XW, Qi FJ, et al. Expression of Ecadherin, betacatenin and p120ctn in the pulmonary sclerosing hemangioma [J]. Lung Cancer, 2007, 57(1): 5459.
44. Wang EH, Liu Y, Xu HT, et al. Abnormal expression and clinicopathologic significance of p120catenin in lung cancer [J]. Histol Histopathol, 2006, 21(8): 841847.
45. Liu Y, Wang Y, Zhang Y, et al. Abnormal expression of p120catenin, Ecadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer [J]. Lung Cancer, 2009, 63(3): 375382.
46. 苗原, 劉洋, 王妍, 等. p120ctn亞型在肺鱗癌、腺癌中表達及意義 [J]. 中國肺癌雜志, 2008, 11(2): 189193.
47. Chu EA, Wu JM, Tunkel DE, et al. Nasopharyngeal carcinoma: the role of the EpsteinBarr virus [J]. Medscape J Med, 2008, 10(7): 165.
48. Dittmer DP, Hilscher CJ, Gulley ML, et al. Multiple pathways for EpsteinBarr virus episome loss from nasopharyngeal carcinoma [J]. Int J Cancer, 2008, 123(9): 21052112.
49. 游淑源, 韓安家, 張芬芬, 等. 鼻咽癌中EB病毒編碼的潛伏膜蛋白1對βcatenin轉錄活性及表達的影響 [J]. 中華病理學雜志, 2010, 39(8): 537541.
50. 葉輝信, 張錫流, 歐海燕, 等. 上皮鈣黏蛋白和連環蛋白120在鼻咽癌組織中的表達及相關性研究 [J]. 臨床耳鼻咽喉頭頸外科雜志, 2009, 23(14): 646648.
51. 歐海玲, 覃宇周, 張錫流, 等. P120連環蛋白在鼻咽癌中的表達及其與細胞凋亡的關系 [J]. 實用醫學雜志, 2009, 25(22): 37493752.
52. Zhang X, Disanto ME. Rhokinase, a common final path of various contractile bladder and ureter stimuli [J]. Handb Exp Pharmacol, 2011, (202): 543568.
53. Mandeville JA, Silva Neto B, Vanni AJ, et al. Pcadherin as a prognostic indicator and a modulator of migratory behaviour in bladder carcinoma cells [J]. BJU Int, 2008, 2(11): 17071714.
54. 林成楚, 許恩賜. 膀胱移行細胞癌中p120ctn的表達及意義 [J]. 山東醫藥, 2008, 48(30): 3637.
55. Silva Neto B, Smith GL, Mandeville JA, et al. Prognostic significance of altered p120 ctn expression in bladder cancer [J]. BJU Int, 2008, 101(6): 746752.
56. 張錫流, 何仕遠, 張力, 等． E鈣黏附蛋白及其相關蛋白在前列腺癌組織中的表達及其臨床意義 [J]. 檢驗醫學, 2006, 21(1): 57.
57. Kaulfuss S, von Hardenberg S, Schweyer S, et al. Leupaxin acts as a mediator in prostate carcinoma progression through deregulation of p120catenin expression [J]. Oncogene, 2009, 28(45): 39713982.
58. van Oort IM, Tomita K, van Bokhoven A, et al. The prognostic value of Ecadherin and the cadherinassociated molecules alpha, beta, gammacatenin and p120ctn in prostate cancer specific survival: a longterm followup study [J]. Prostate, 2007, 67(13): 14321438.
59. Kallakury BV, Sheehan CE, WinnDeen E, et al. Decreased expression of catenins (alpha and beta), p120 CTN, and Ecadherin cell adhesion proteins and Ecadherin gene promoter methylation in prostatic adenocarcinomas [J]. Cancer, 2001, 92(11): 27862795.
60. Freeman JW, McGrath P, Bondada V, et al. Prognostic significance of proliferation associated nucleolar antigen p120 in human breast carcinoma [J].Cancer Res, 1991, 51(8): 19731978.
61. Paredes J, Correia AL, Ribeiro AS, et al. Expression of p120catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines [J]. Cell Oncol, 2007, 29(6): 467476.
62. Sarrió D, PérezMies B, Hardisson D, et al. Cytoplasmic localization of p120ctn and Ecadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions [J]. Oncogene, 2004, 23(19): 32723283.
63. Dabbs DJ, Bhargava R, Chivukula M. Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin [J]. Am J Surg Pathol, 2007, 31(3): 427437.
64. 李曉鳴, 溫漓潮, 朱任之. 乳腺典型髓樣癌與非典型髓樣癌生物學行為差異的研究 [J]. 中國普外基礎與臨床雜志, 2003, 10(3): 268269.
65. Boriani S, Bandiera S, Biagini R, et al. Chordoma of the mobilesp ine: fifty years of experience [J]. Spine (Phila Pa 1976), 2006, 31(4): 493503.
66. Guirat A, Affes N, Boujlbene S, et al. Sacral chordoma: a rare tumor of the buttocks [J]. Ann Dermatol Venereol, 2009, 136(67): 526529.
67. Schwab JH, Boland PJ, Agaram NP, et al. Chordoma and chondrosarcoma gene profile: implications for immunotherapy [J]. Cancer Immunol Immunother, 2009, 58(3): 339349.
68. 馬俊明, 楊興海, 黃權, 等. Ecadherin和P120ctn在脊柱脊索瘤中的異常表達 [J]. 脊柱外科雜志, 2009, 7(4): 193197.
69. Chartier NT, Oddou CI, Lainé MG, et al. Cyclindependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)dependent cell growth control: a new role for p120ctn in cancer [J]. Cancer Res, 2007, 67(20): 97819790.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

p120-Catenin━━A New Member of Catenin Family

Abstract Full text Figures/Tables Video References Cited by

Format

Content