Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

PANG Junhao , WANG Chongshu.

The First Department of General Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637007, Sichuan Province, China;

Corresponding?author：

Keywords：

Advanced gastric carcinoma; Regional chemotherapy; Intraperitoneal chemotherapy; Arterial infusion chemotherapy; Current status

Video：

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Objective To explore the feasibility, safety, efficacy and mechanism of intraoperative regional chemotherapy of advanced gastric cancer.
Methods The related literatures were reviewed and analyzed.
Results Compared with systemic chemotherapy, intraoperative regional chemotherapy of advanced gastric cancer could increase blood drug concentration of cancerous tissue, reduce the systemic toxic side effects, increase survival rate and improve the quality of life.
Conclusion Intraoperative regional chemotherapy, as an adjuvant treatment of advanced gastric cancer, has been gradually applied to clinic because of the definite curative effect, which is worth popularizing. However, it needs systemic researches and accumulation of cases.

Citation： PANG Junhao,WANG Chongshu.. Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2010, 17(2): 205-208. doi: Copy

1.	Ajani JA. Evolving chemotherapy for advanced gastric cancer [J]. Oncologist, 2005; 10 Suppl 3: 4958.
2.	Sugarbaker PH. Adjuvant intraperitoneal chemotherapy for advanced primary gastric cancer [J]. Scand J Surg, 2006; 95(4): 270273.
3.	Newman E, Potmesil M, Ryan T, et al. Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase Ⅱ study [J]. Semin Oncol, 2005; 32(6 Suppl 9): S97S100.
4.	Allal AS, Zwahlen D, Bründler MA, et al. Neoadjuvant radiochemotherapy for locally advanced gastric cancer: longterm results of a phase Ⅰ trial [J]. Int J Radiat Oncol Biol Phys, 2005; 63(5): 12861289.
5.	Marrelli D, Roviello F, de Manzoni, et al. Different patterns of recurrence in gastric cancer depending on Lauren’s histological type: longitudinal study [J]. World J Surg, 2002; 26(9): 11601165.
6.	Paget S. The distribution of secondary growths in cancer of the breast. 1889 [J]. Cancer Metastasis Rev, 1989; 8(2): 98101.
7.	Sugarbaker PH, Cunliffe WJ, Belliveau J, et al. Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer [J]. Semin Oncol, 1989; 16(4 Suppl 6): 8397.
8.	Sethna KS, Sugarbaker PH. New prospects for the control of peritoneal surface dissemination of gastric cancer using perioperative intraperitoneal chemotherapy [J]. Cancer Therapy, 2004; 2: 7984.
9.	何濤, 楊志明, 伍曉汀. 胃癌腹膜播散轉移機理的研究進展 [J]. 中國普外基礎與臨床雜志, 2005; 12(1): 4345.
10.	Sarner M. Treatment of pancreatic exocrine deficiency [J]. World J Surg, 2003; 27(11): 11921195.
11.	Araki K, Yamamoto H, Kobayashi M, et al. Experimental and clinical study on intraoperative local infusion chemotherapy (ILIC) for advanced gastric carcinoma [J]. Gan To Kagaku Ryoho, 1995; 22 (11): 15311534.
12.	Kobayashi M, Yamamoto H, Sugimoto T, et al. Intraoperative local infusion chemotherapy (ILIC) for gastric cancer [J]. Gan To Kagaku Ryoho, 1998; 25(9): 12811283.
13.	孫世良, 溫海燕, 張連陽. 現代大腸癌診斷與治療 [M]. 第1版. 重慶: 重慶出版社, 2004： 393298.
14.	Pohlen U, Rieger H, KunickPohlen S, et al. Phase Ⅱ study of regional chemotherapy using the hypoxic abdominal perfusion technique in advanced abdominal carcinoma. 5FU pharmacokinetics, complications and outcome [J]. Anticancer Res, 2007; 27(1B): 667674.
15.	Maurer CA, Borner M, Büchler MW. Regional chemotherapy of gastrointestinal cancer [J]. Dig Surg,1997; 14(1): 922.
16.	朱志東, 蒲永東. 氟尿嘧啶經胃左動脈和外周靜脈化療的藥代動力學比較 [J]. 中國胃腸外科雜志, 2000; 3(1): 2830.
17.	Shchepotin IB, Chorny V, Hanfelh J, et al. Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J]. J Gastrointest Surg, 1999; 3(4): 426431.
18.	何運勝, 姜淮蕪, 汪盛賢，等. 進展期胃癌術中動脈化療對p53和ki67表達及細胞凋亡作用的影響 [J]. 中國現代普通外科進展, 2009; 12(3): 201205.
19.	杜江, 王崇樹, 張才全, 等. 高效液相色譜法測定直腸癌術中區域化療血液、盆腔液和組織5氟尿嘧啶濃度 [J]. 中國藥房, 2006; 17(20): 15641566.
20.	金懋林. 晚期胃癌全身化學治療最新進展 [J]. 中國處方藥, 2008; 7(76): 7476.
21.	郭花，朱金水. 胃癌腹腔化療進展 [J]. 國際消化病雜志, 2008; 28(1): 911.
22.	宰守峰, 王簡, 郭明, 等. 胃癌患者術中腹腔內低滲溫熱腹腔灌注化療的臨床研究 [J]. 腫瘤基礎與臨床, 2006; 19(2): 122123.
23.	陳志新, 張波. 胃癌綜合治療現狀及展望 [J]. 中國普外基礎與臨床雜志, 2008; 15(1): 7173.
24.	de Bree E, Rosing H, Beijnen JH, et al. Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer [J]. Anticancer Drugs, 2003; 14(2): 103110.
25.	Brigand C, Arvieux C, Gilly FN, et al. Treatment of peritoneal carcinomatosis in gastric cancers [J]. Dig Dis, 2004; 22(4): 366373.
26.	倪家連, 劉曉明, 鄭寶珍, 等. 活體胃血供的特點及其臨床意義 [J]. 中國普通外科雜志, 2003; 12(4): 291293.
27.	邰生. 術中瘤區動脈灌注化療胃癌、賁門癌65例體會 [J]. 鎮江醫學院報, 1999; 9(2): 249230.
28.	Ikeda O, Tamura Y, Nakasone Y, et al. Evaluation of extrahepatic perfusion of anticancer drugs in the right gastric arterial region on fused images using combined CT/SPECT: is extrahepatic perfusion predictive of gastric toxicity? [J]. Cardiovasc Intervent Radiol, 2007; 30(3): 392397.
29.	Garofalo A, Valle M, Garcia J, et al. Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites [J]. Eur J Surg Oncol, 2006; 32(6): 682685.
30.	Kuhn JA, McLoughlin JM, Harris DC, et al. Intraperitoneal hypert hermic chemot herapy: experience at Baylor University Medical Center [J]. Proc (Bayl Univ Med Cent), 2002; 15(4): 359362.
31.	金永鋒. 胃癌根治術中腹腔熱灌注化療對預后的影響 [J]. 浙江臨床醫學, 2007; 9(3): 357358.
32.	肖乾虎, 彭兵, 賴毅, 等. 胃癌術中動脈區域灌注化療與全身靜脈化療的臨床療效比較 [J]. 華西醫科大學學報, 2001; 32(4): 585586.
33.	彭兵, 肖乾虎, 王向東, 等. 胃癌術前介入治療、術中區域性動脈灌注化療及全身化療的療效評價 [J]. 華西醫科大學學報， 2002; 33(2): 314315.
34.	徐圣德, 高斌, 文剛, 等. 術前區域動脈熱化療對進展期胃癌病理學的影響 [J]. 醫學影像學雜志, 2008; 18(10): 11561159.
35.	夏術森, 張才全, 王崇樹, 等. 胃癌術中區域動脈灌注化療作用的初步研究 [J]. 重慶醫科大學學報, 2009; 34(3): 293296.
36.	張啟文, 趙偉, 王德友, 等. 進展期胃癌術中化療加低滲熱療的臨床應用 [J]. 中國現代普通外科進展, 2004; 7(2): 72.
37.	Tentes AA, Markakidis SK, Karanikiotis C, et al. Intraarterial chemotherapy as an adjuvant treatment in locally advanced gastric cancer [J]. Langenbecks Arch Surg, 2006; 391(2): 124129.
38.	劉啟領, 陳建華. 胃周血管離斷術加動脈灌注化療治療晚期胃癌療效分析 [J]. 中國藥物與臨床, 2007; 7(9): 716717.

1. Ajani JA. Evolving chemotherapy for advanced gastric cancer [J]. Oncologist, 2005; 10 Suppl 3: 4958.
2. Sugarbaker PH. Adjuvant intraperitoneal chemotherapy for advanced primary gastric cancer [J]. Scand J Surg, 2006; 95(4): 270273.
3. Newman E, Potmesil M, Ryan T, et al. Neoadjuvant chemotherapy, surgery, and adjuvant intraperitoneal chemotherapy in patients with locally advanced gastric or gastroesophageal junction carcinoma: a phase Ⅱ study [J]. Semin Oncol, 2005; 32(6 Suppl 9): S97S100.
4. Allal AS, Zwahlen D, Bründler MA, et al. Neoadjuvant radiochemotherapy for locally advanced gastric cancer: longterm results of a phase Ⅰ trial [J]. Int J Radiat Oncol Biol Phys, 2005; 63(5): 12861289.
5. Marrelli D, Roviello F, de Manzoni, et al. Different patterns of recurrence in gastric cancer depending on Lauren’s histological type: longitudinal study [J]. World J Surg, 2002; 26(9): 11601165.
6. Paget S. The distribution of secondary growths in cancer of the breast. 1889 [J]. Cancer Metastasis Rev, 1989; 8(2): 98101.
7. Sugarbaker PH, Cunliffe WJ, Belliveau J, et al. Rationale for integrating early postoperative intraperitoneal chemotherapy into the surgical treatment of gastrointestinal cancer [J]. Semin Oncol, 1989; 16(4 Suppl 6): 8397.
8. Sethna KS, Sugarbaker PH. New prospects for the control of peritoneal surface dissemination of gastric cancer using perioperative intraperitoneal chemotherapy [J]. Cancer Therapy, 2004; 2: 7984.
9. 何濤, 楊志明, 伍曉汀. 胃癌腹膜播散轉移機理的研究進展 [J]. 中國普外基礎與臨床雜志, 2005; 12(1): 4345.
10. Sarner M. Treatment of pancreatic exocrine deficiency [J]. World J Surg, 2003; 27(11): 11921195.
11. Araki K, Yamamoto H, Kobayashi M, et al. Experimental and clinical study on intraoperative local infusion chemotherapy (ILIC) for advanced gastric carcinoma [J]. Gan To Kagaku Ryoho, 1995; 22 (11): 15311534.
12. Kobayashi M, Yamamoto H, Sugimoto T, et al. Intraoperative local infusion chemotherapy (ILIC) for gastric cancer [J]. Gan To Kagaku Ryoho, 1998; 25(9): 12811283.
13. 孫世良, 溫海燕, 張連陽. 現代大腸癌診斷與治療 [M]. 第1版. 重慶: 重慶出版社, 2004： 393298.
14. Pohlen U, Rieger H, KunickPohlen S, et al. Phase Ⅱ study of regional chemotherapy using the hypoxic abdominal perfusion technique in advanced abdominal carcinoma. 5FU pharmacokinetics, complications and outcome [J]. Anticancer Res, 2007; 27(1B): 667674.
15. Maurer CA, Borner M, Büchler MW. Regional chemotherapy of gastrointestinal cancer [J]. Dig Surg,1997; 14(1): 922.
16. 朱志東, 蒲永東. 氟尿嘧啶經胃左動脈和外周靜脈化療的藥代動力學比較 [J]. 中國胃腸外科雜志, 2000; 3(1): 2830.
17. Shchepotin IB, Chorny V, Hanfelh J, et al. Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J]. J Gastrointest Surg, 1999; 3(4): 426431.
18. 何運勝, 姜淮蕪, 汪盛賢，等. 進展期胃癌術中動脈化療對p53和ki67表達及細胞凋亡作用的影響 [J]. 中國現代普通外科進展, 2009; 12(3): 201205.
19. 杜江, 王崇樹, 張才全, 等. 高效液相色譜法測定直腸癌術中區域化療血液、盆腔液和組織5氟尿嘧啶濃度 [J]. 中國藥房, 2006; 17(20): 15641566.
20. 金懋林. 晚期胃癌全身化學治療最新進展 [J]. 中國處方藥, 2008; 7(76): 7476.
21. 郭花，朱金水. 胃癌腹腔化療進展 [J]. 國際消化病雜志, 2008; 28(1): 911.
22. 宰守峰, 王簡, 郭明, 等. 胃癌患者術中腹腔內低滲溫熱腹腔灌注化療的臨床研究 [J]. 腫瘤基礎與臨床, 2006; 19(2): 122123.
23. 陳志新, 張波. 胃癌綜合治療現狀及展望 [J]. 中國普外基礎與臨床雜志, 2008; 15(1): 7173.
24. de Bree E, Rosing H, Beijnen JH, et al. Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer [J]. Anticancer Drugs, 2003; 14(2): 103110.
25. Brigand C, Arvieux C, Gilly FN, et al. Treatment of peritoneal carcinomatosis in gastric cancers [J]. Dig Dis, 2004; 22(4): 366373.
26. 倪家連, 劉曉明, 鄭寶珍, 等. 活體胃血供的特點及其臨床意義 [J]. 中國普通外科雜志, 2003; 12(4): 291293.
27. 邰生. 術中瘤區動脈灌注化療胃癌、賁門癌65例體會 [J]. 鎮江醫學院報, 1999; 9(2): 249230.
28. Ikeda O, Tamura Y, Nakasone Y, et al. Evaluation of extrahepatic perfusion of anticancer drugs in the right gastric arterial region on fused images using combined CT/SPECT: is extrahepatic perfusion predictive of gastric toxicity? [J]. Cardiovasc Intervent Radiol, 2007; 30(3): 392397.
29. Garofalo A, Valle M, Garcia J, et al. Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites [J]. Eur J Surg Oncol, 2006; 32(6): 682685.
30. Kuhn JA, McLoughlin JM, Harris DC, et al. Intraperitoneal hypert hermic chemot herapy: experience at Baylor University Medical Center [J]. Proc (Bayl Univ Med Cent), 2002; 15(4): 359362.
31. 金永鋒. 胃癌根治術中腹腔熱灌注化療對預后的影響 [J]. 浙江臨床醫學, 2007; 9(3): 357358.
32. 肖乾虎, 彭兵, 賴毅, 等. 胃癌術中動脈區域灌注化療與全身靜脈化療的臨床療效比較 [J]. 華西醫科大學學報, 2001; 32(4): 585586.
33. 彭兵, 肖乾虎, 王向東, 等. 胃癌術前介入治療、術中區域性動脈灌注化療及全身化療的療效評價 [J]. 華西醫科大學學報， 2002; 33(2): 314315.
34. 徐圣德, 高斌, 文剛, 等. 術前區域動脈熱化療對進展期胃癌病理學的影響 [J]. 醫學影像學雜志, 2008; 18(10): 11561159.
35. 夏術森, 張才全, 王崇樹, 等. 胃癌術中區域動脈灌注化療作用的初步研究 [J]. 重慶醫科大學學報, 2009; 34(3): 293296.
36. 張啟文, 趙偉, 王德友, 等. 進展期胃癌術中化療加低滲熱療的臨床應用 [J]. 中國現代普通外科進展, 2004; 7(2): 72.
37. Tentes AA, Markakidis SK, Karanikiotis C, et al. Intraarterial chemotherapy as an adjuvant treatment in locally advanced gastric cancer [J]. Langenbecks Arch Surg, 2006; 391(2): 124129.
38. 劉啟領, 陳建華. 胃周血管離斷術加動脈灌注化療治療晚期胃癌療效分析 [J]. 中國藥物與臨床, 2007; 7(9): 716717.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Status on Intraoperative Regional Chemotherapy of Advanced Gastric Cancer

Abstract Full text Figures/Tables Video References Cited by

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