Comparison on Characteristics of Tumor Recurrence of Hepatocellular Carcinoma after Liver Transplantation and Hepatectomy_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Lu Bo , WEN Tianfu.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding?author：

Keywords：

Hepatocellular carcinoma,Liver transplantation,Hepatectomy,Recurrence

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【Abstract】Objective To explore the different characteristics of tumor recurrence after liver transplantation (LT) and hepatectomy (HC) in patients with hepatocellular carcinoma (HCC). Methods The literatures about tumor recurrence of HCC after LT and HC were reviewed and their characteristics were compared. Results There are distinctions of recurrence rates, time, common sites between the recurred tumors after LT and HC, and their correlation factors and mechanisms of recurrence are also different. Conclusion Preventive measures should be strengthened and treatments should be more targeted according to the different characteristics of tumor recurrence after LT and HC to improve postoperative life quality and increase the survival rate.

Citation： Lu Bo,WEN Tianfu.. Comparison on Characteristics of Tumor Recurrence of Hepatocellular Carcinoma after Liver Transplantation and Hepatectomy. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2008, 15(3): 166-170. doi: Copy

1.	68 Poon RT, Fan ST, Lo CM, et al. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation [ J ] . Ann Surg, 2002; 235(3) ∶ 373.
2.	Jemal A, Murray T, Ward E, et al. Cancer statistics， 2005 [J]. CA Cancer J Clin, 2005； 55（1）∶10.
3.	Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis [J]. N Engl J Med, 1996； 334(11)∶693.
4.	Marsh JW, Dvorchik I, Bonham CA, et al. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? [J]. Cancer， 2000; 88(3)∶538.
5.	Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival [J]. Hepatology, 2001; 33(6)∶1394.
6.	嚴律南，王震俠. 肝癌肝移植的適應證及應用前景 [J]. 中國普外基礎與臨床雜志， 2006; 13（2）∶132.
7.	樊嘉, 周儉, 徐泱, 等. 肝癌肝移植適應證的選擇: 上海復旦標準 [J]. 中華醫學雜志, 2006; 86(18)∶1227.
8.	吳階平，裘法祖主編. 黃家駟外科學（上、中、下） [M]. 第6版. 北京: 人民衛生出版社, 2000∶1230~1233.
9.	Sun HC, Tang ZY. Preventive treatment for recurrence after curative resection of hepatocellular carcinoma——a literature review of randomized control trial [J]. World J Gasrtoenterol, 2003; 9(4)∶635.
10.	黃潔夫主編. 肝臟膽道腫瘤外科學 [M]. 北京: 人民衛生出版社, 1999∶673~677.
11.	湯釗猷, 余業勤主編. 原發性肝癌(2) [M]. 上海: 上海科學技術出版社, 1998∶438~440.
12.	Regalia E, Fassati LR, Valente U, et al. Pattern and management of recurrent hepatocellular carcinoma after liver transplantation [J]. J Hepatobiliary Pancreat Surg, 1998； 5(1)∶29.
13.	Roayaie S, Schwartz JD, Sung MW, et al. Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis [J]. Liver Transpl, 2004; 10(4)∶534.
14.	吳天鳴, 楊翔, 賀強, 等. 肝移植治療原發性肝癌的探討 [J]. 臨床外科雜志, 2002; 10（6）∶371.
15.	鄭樹森, 吳健, 黃東勝, 等. 肝臟移植在治療肝臟惡性腫瘤中的作用 [J]. 中華肝膽外科雜志, 2002; 8（5）∶265.
16.	Kumada T, Nakano S, Takeda I, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma [J]. Hepatology, 1997; 25(1)∶87.
17.	Schlitt HJ, Neipp M, Weimann A, et al. Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation [J]. J Clin Oncol, 1999; 17(1)∶324.
18.	Kakumu S. Trends in liver cancer researched by the Liver Cancer Study Group of Japan [J]. Hepatol Res, 2002; 24(Suppl)∶21.
19.	Ikai I, Itai Y, Okita K, et al. Report of the 15th follow-up survey of primary liver cancer [J]. Hepatol Res, 2004; 28(1)∶21.
20.	林芷英, 湯釗猷, 余業勤, 等. 原發性肝癌根治切除后的復發和治療 [J]. 中華外科雜志, 1991; 29（2）∶93.
21.	楊世忠, 董家鴻. 肝癌肝外轉移復發的臨床研究進展 [J]. 中華普通外科雜志, 2004; 19（1）∶56.
22.	Katyal S, Oliver JH 3rd, Peterson MS, et al. Extrahepatic metastases of hepatocellular carcinoma [J]. Radiology, 2000; 216(3)∶698.
23.	Hemming AW, Cattral MS, Reed AI, et al. Liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2001; 233(5)∶652.
24.	Salizzoni M, Romagnoli R, Lupo F, et al. Microscopic vascular invasion detected by anti-CD34 immunohistochemistry as a predictor of recurrence of hepatocellular carcinoma after liver transplantation [J]. Transplantation, 2003; 76(5)∶844.
25.	Shah SA, Tan JC, McGilvray ID, et al. Accuracy of staging as a predictor for recurrence after liver transplantation for hepatocellular carcinoma [J]. Transplantation, 2006; 81(12)∶1633.
26.	Bismuth H, Majno PE, Adam R. Liver transplantation for hepatocellular carcinoma [J]. Semin Liver Dis, 1999; 19(3)∶311.
27.	Roayaie S, Frischer JS, Emre SH, et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters [J]. Ann Surg, 2002; 235(4)∶533.
28.	Jonas S, Bechstein WO, Steinmüller T, et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis [J]. Hepatology, 2001; 33(5)∶1080.
29.	Grasso A, Stigliano R, Morisco F, et al. Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant study [J]. Transplantation, 2006; 81(11)∶1532.
30.	Pawlik TM, Delman KA, Vauthey JN, et al. Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma [J]. Liver Transpl, 2005; 11(9)∶1086.
31.	Plessier A, Codes L, Consigny Y, et al. Underestimation of the influence of satellite nodules as a risk factor for post-transplantation recurrence in patients with small hepatocellular carcinoma [J]. Liver Transpl, 2004; 10(2 Suppl 1)∶S86.
32.	Esnaola NF,Lauwers GY,Mirza NQ, et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation [J]. J Gastrointest Surg, 2002； 6(2)∶224.
33.	Vivarelli M, Bellusci R, Cucchetti A, et al. Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? [J]. Transplantation， 2002; 74(12)∶1746.
34.	Herrero JI, Sangro B, Quiroga J, et al. Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma [J]. Liver Transpl, 2001; 7(7)∶631.
35.	黃潔夫. 肝移植治療原發性肝癌的現狀及前景 [J]. 肝膽外科雜志, 1999； 7（3）∶163.
36.	Vivarelli M, Cucchetti A, Piscaglia F, et al. Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma: key role of immunosuppression [J]. Liver Transpl, 2005; 11(5)∶497.
37.	Majno P, Giostra E, Mentha G; Geneva Liver Cancer Study. Is there a customised immunosuppressive regimen for patients transplanted with hepatocellular carcinoma? [J]. J Hepatol, 2005; 43(4)∶577.
38.	楊甲梅, 溫增慶. 肝移植術治療原發性肝癌 [J]. 肝膽外科雜志,1999； 7（3）∶166.
39.	Guba M,Von Breitenbuch P,Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor [J]. Nat Med, 2002； 8(2)∶128.
40.	Luan FL, Hojo M, Maluccio M, et al. Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy [J]. Transplantation, 2002; 73(10)∶1565.
41.	王征, 樊嘉, 周儉, 等. 雷帕霉素抑制肝癌細胞生長及轉移的實驗研究 [J]. 中華醫學雜志， 2006; 86(24)∶1666.
42.	Mazzaferro V, Battiston C, Perrone S, et al. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study [J]. Ann Surg, 2004; 240(5)∶900.
43.	Fontana RJ, Hamidullah H, Nghiem H, et al. Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma: a safe and effective bridge to liver transplantation [J]. Liver Transpl, 2002; 8(12)∶1165.
44.	Ghobrial RM, Shimoda M, Farmer DG, et al. Factors determining outcome of liver transplantation for hepatocellular carcinoma associated with hepatitis C cirrhosis [J]. Transplant Proc, 2001; 33(1-2)∶1358.
45.	Sderdahl G, Bckman L, Isoniemi H, et al. A prospective,randomized, multi-centre trial of systemic adjuvant chemotherapy versus no additional treatment in liver transplantation for hepatocellular carcinoma [J]. Transpl Int, 2006； 19(4)∶288.
46.	Adam R, Azoulay D, Castaing D, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? [J]. Ann Surg, 2003; 238(4)∶508.
47.	Belghiti J, Cortes A, Abdalla EK, et al. Resection prior to liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2003; 238(6)∶885.
48.	Knechtle SJ. Challenging choices: liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2004; 239(2)∶160.
49.	Regimbeau JM, Abdalla EK, Vauthey JN, et al. Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study [J]. J Surg Oncol, 2004; 85(1)∶36.
50.	Poon RT, Fan ST, Ng IO, et al. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma [J]. Cancer, 2000; 89(3)∶500.
51.	季錫清, 李朝龍, 楊進城, 等. 影響原發性肝細胞肝癌切除術預后的多因素分析 [J]. 中國普通外科雜志, 2004； 19(2)∶91.
52.	Jwo SC, Chiu JH, Chau GY, et al. Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection [J]. Hepatology, 1992; 16(6)∶1367.
53.	Huang YH, Wu JC, Chen CH, et al. Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area [J]. Liver Int, 2005; 25(2)∶236.
54.	Yamamoto J, Kosuge T, Takayama T, et al. Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomy [J]. Surgery, 1994; 115(3)∶303.
55.	Chau GY, Lui WY, Tsay SH, et al. Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Childs’ A patients [J]. J Surg Oncol, 1997; 66(2)∶122.
56.	Poon RT, Fan ST, Ng IO, et al. Significance of resection margin in hepatectomy for hepatocellular carcinoma: A critical reappraisal [J]. Ann Surg, 2000; 231(4)∶544.
57.	徐立, 石明, 張亞奇, 等. 肝細胞癌手術切緣對患者術后復發與生存的影響 [J]. 中華腫瘤雜志, 2006； 28(1)∶47.
58.	Shi M, Zhang CQ, Zhang YQ, et al. Micrometastases of solitary hepatocellular carcinoma and appropriate resection margin [J]. World J Surg, 2004; 28(4)∶376.
59.	Wu CC, Ho YZ, Ho WL, et al. Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinoma: a reappraisal [J]. Br J Surg, 1995; 82(1)∶122.
60.	王槐志, 董家鴻, 王曙光, 等. 肝移植治療原發性肝癌 [J]. 實用臨床醫藥雜志, 2003； 7（1）∶27.
61.	張樹民, 曾昭沖, 孫菁, 等. 肝細胞肝癌肺轉移的預后因素分析 [J]. 實用腫瘤雜志, 2005； 20(5)∶395.
62.	Nielsen OS, Munro AJ, Tannock IF. Bone metastases: pathophysiology and management policy [J]. J Clin Oncol, 1991; 9(3)∶509.
63.	Rasmusson B, Vejborg I, Jensen AB, et al. Irradiation of bone metastases in breast cancer patients: a randomized study with 1 year follow-up [J]. Radiother Oncol, 1995; 34(3)∶179.
64.	周信達, 劉銀坤. 原發性肝癌復發轉移防治的臨床與基礎研究 [J]. 中國腫瘤, 2001； 10(2)∶65.
65.	梁安民, 莫欽國. 原發性肝癌的綜合治療——附607例報告 [J]. 癌癥, 2003； 23（2）∶104.
66.	Ebara M, Okabe S, Kita K, et al. Percutaneous ethanol injection for small hepatocellular carcinoma: therapeutic efficacy based on 20-year observation [J]. J Hepatol, 2005; 43(3)∶458.
67.	Lencioni R, Cioni D, Crocetti L, et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation [J]. Radiology, 2005; 234(3)∶961.
68.	賴東明, 羅葆明, 劉超, 等. 原發性肝癌術后復發的射頻和無水酒精治療 [J]. 中國普外基礎與臨床雜志, 2006； 13(2)∶167.

1. 68 Poon RT, Fan ST, Lo CM, et al. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation [ J ] . Ann Surg, 2002; 235(3) ∶ 373.
2. Jemal A, Murray T, Ward E, et al. Cancer statistics， 2005 [J]. CA Cancer J Clin, 2005； 55（1）∶10.
3. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis [J]. N Engl J Med, 1996； 334(11)∶693.
4. Marsh JW, Dvorchik I, Bonham CA, et al. Is the pathologic TNM staging system for patients with hepatoma predictive of outcome? [J]. Cancer， 2000; 88(3)∶538.
5. Yao FY, Ferrell L, Bass NM, et al. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival [J]. Hepatology, 2001; 33(6)∶1394.
6. 嚴律南，王震俠. 肝癌肝移植的適應證及應用前景 [J]. 中國普外基礎與臨床雜志， 2006; 13（2）∶132.
7. 樊嘉, 周儉, 徐泱, 等. 肝癌肝移植適應證的選擇: 上海復旦標準 [J]. 中華醫學雜志, 2006; 86(18)∶1227.
8. 吳階平，裘法祖主編. 黃家駟外科學（上、中、下） [M]. 第6版. 北京: 人民衛生出版社, 2000∶1230~1233.
9. Sun HC, Tang ZY. Preventive treatment for recurrence after curative resection of hepatocellular carcinoma——a literature review of randomized control trial [J]. World J Gasrtoenterol, 2003; 9(4)∶635.
10. 黃潔夫主編. 肝臟膽道腫瘤外科學 [M]. 北京: 人民衛生出版社, 1999∶673~677.
11. 湯釗猷, 余業勤主編. 原發性肝癌(2) [M]. 上海: 上海科學技術出版社, 1998∶438~440.
12. Regalia E, Fassati LR, Valente U, et al. Pattern and management of recurrent hepatocellular carcinoma after liver transplantation [J]. J Hepatobiliary Pancreat Surg, 1998； 5(1)∶29.
13. Roayaie S, Schwartz JD, Sung MW, et al. Recurrence of hepatocellular carcinoma after liver transplant: patterns and prognosis [J]. Liver Transpl, 2004; 10(4)∶534.
14. 吳天鳴, 楊翔, 賀強, 等. 肝移植治療原發性肝癌的探討 [J]. 臨床外科雜志, 2002; 10（6）∶371.
15. 鄭樹森, 吳健, 黃東勝, 等. 肝臟移植在治療肝臟惡性腫瘤中的作用 [J]. 中華肝膽外科雜志, 2002; 8（5）∶265.
16. Kumada T, Nakano S, Takeda I, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma [J]. Hepatology, 1997; 25(1)∶87.
17. Schlitt HJ, Neipp M, Weimann A, et al. Recurrence patterns of hepatocellular and fibrolamellar carcinoma after liver transplantation [J]. J Clin Oncol, 1999; 17(1)∶324.
18. Kakumu S. Trends in liver cancer researched by the Liver Cancer Study Group of Japan [J]. Hepatol Res, 2002; 24(Suppl)∶21.
19. Ikai I, Itai Y, Okita K, et al. Report of the 15th follow-up survey of primary liver cancer [J]. Hepatol Res, 2004; 28(1)∶21.
20. 林芷英, 湯釗猷, 余業勤, 等. 原發性肝癌根治切除后的復發和治療 [J]. 中華外科雜志, 1991; 29（2）∶93.
21. 楊世忠, 董家鴻. 肝癌肝外轉移復發的臨床研究進展 [J]. 中華普通外科雜志, 2004; 19（1）∶56.
22. Katyal S, Oliver JH 3rd, Peterson MS, et al. Extrahepatic metastases of hepatocellular carcinoma [J]. Radiology, 2000; 216(3)∶698.
23. Hemming AW, Cattral MS, Reed AI, et al. Liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2001; 233(5)∶652.
24. Salizzoni M, Romagnoli R, Lupo F, et al. Microscopic vascular invasion detected by anti-CD34 immunohistochemistry as a predictor of recurrence of hepatocellular carcinoma after liver transplantation [J]. Transplantation, 2003; 76(5)∶844.
25. Shah SA, Tan JC, McGilvray ID, et al. Accuracy of staging as a predictor for recurrence after liver transplantation for hepatocellular carcinoma [J]. Transplantation, 2006; 81(12)∶1633.
26. Bismuth H, Majno PE, Adam R. Liver transplantation for hepatocellular carcinoma [J]. Semin Liver Dis, 1999; 19(3)∶311.
27. Roayaie S, Frischer JS, Emre SH, et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters [J]. Ann Surg, 2002; 235(4)∶533.
28. Jonas S, Bechstein WO, Steinmüller T, et al. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis [J]. Hepatology, 2001; 33(5)∶1080.
29. Grasso A, Stigliano R, Morisco F, et al. Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant study [J]. Transplantation, 2006; 81(11)∶1532.
30. Pawlik TM, Delman KA, Vauthey JN, et al. Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma [J]. Liver Transpl, 2005; 11(9)∶1086.
31. Plessier A, Codes L, Consigny Y, et al. Underestimation of the influence of satellite nodules as a risk factor for post-transplantation recurrence in patients with small hepatocellular carcinoma [J]. Liver Transpl, 2004; 10(2 Suppl 1)∶S86.
32. Esnaola NF,Lauwers GY,Mirza NQ, et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation [J]. J Gastrointest Surg, 2002； 6(2)∶224.
33. Vivarelli M, Bellusci R, Cucchetti A, et al. Low recurrence rate of hepatocellular carcinoma after liver transplantation: better patient selection or lower immunosuppression? [J]. Transplantation， 2002; 74(12)∶1746.
34. Herrero JI, Sangro B, Quiroga J, et al. Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma [J]. Liver Transpl, 2001; 7(7)∶631.
35. 黃潔夫. 肝移植治療原發性肝癌的現狀及前景 [J]. 肝膽外科雜志, 1999； 7（3）∶163.
36. Vivarelli M, Cucchetti A, Piscaglia F, et al. Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma: key role of immunosuppression [J]. Liver Transpl, 2005; 11(5)∶497.
37. Majno P, Giostra E, Mentha G; Geneva Liver Cancer Study. Is there a customised immunosuppressive regimen for patients transplanted with hepatocellular carcinoma? [J]. J Hepatol, 2005; 43(4)∶577.
38. 楊甲梅, 溫增慶. 肝移植術治療原發性肝癌 [J]. 肝膽外科雜志,1999； 7（3）∶166.
39. Guba M,Von Breitenbuch P,Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor [J]. Nat Med, 2002； 8(2)∶128.
40. Luan FL, Hojo M, Maluccio M, et al. Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy [J]. Transplantation, 2002; 73(10)∶1565.
41. 王征, 樊嘉, 周儉, 等. 雷帕霉素抑制肝癌細胞生長及轉移的實驗研究 [J]. 中華醫學雜志， 2006; 86(24)∶1666.
42. Mazzaferro V, Battiston C, Perrone S, et al. Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation: a prospective study [J]. Ann Surg, 2004; 240(5)∶900.
43. Fontana RJ, Hamidullah H, Nghiem H, et al. Percutaneous radiofrequency thermal ablation of hepatocellular carcinoma: a safe and effective bridge to liver transplantation [J]. Liver Transpl, 2002; 8(12)∶1165.
44. Ghobrial RM, Shimoda M, Farmer DG, et al. Factors determining outcome of liver transplantation for hepatocellular carcinoma associated with hepatitis C cirrhosis [J]. Transplant Proc, 2001; 33(1-2)∶1358.
45. Sderdahl G, Bckman L, Isoniemi H, et al. A prospective,randomized, multi-centre trial of systemic adjuvant chemotherapy versus no additional treatment in liver transplantation for hepatocellular carcinoma [J]. Transpl Int, 2006； 19(4)∶288.
46. Adam R, Azoulay D, Castaing D, et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? [J]. Ann Surg, 2003; 238(4)∶508.
47. Belghiti J, Cortes A, Abdalla EK, et al. Resection prior to liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2003; 238(6)∶885.
48. Knechtle SJ. Challenging choices: liver transplantation for hepatocellular carcinoma [J]. Ann Surg, 2004; 239(2)∶160.
49. Regimbeau JM, Abdalla EK, Vauthey JN, et al. Risk factors for early death due to recurrence after liver resection for hepatocellular carcinoma: results of a multicenter study [J]. J Surg Oncol, 2004; 85(1)∶36.
50. Poon RT, Fan ST, Ng IO, et al. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma [J]. Cancer, 2000; 89(3)∶500.
51. 季錫清, 李朝龍, 楊進城, 等. 影響原發性肝細胞肝癌切除術預后的多因素分析 [J]. 中國普通外科雜志, 2004； 19(2)∶91.
52. Jwo SC, Chiu JH, Chau GY, et al. Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection [J]. Hepatology, 1992; 16(6)∶1367.
53. Huang YH, Wu JC, Chen CH, et al. Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area [J]. Liver Int, 2005; 25(2)∶236.
54. Yamamoto J, Kosuge T, Takayama T, et al. Perioperative blood transfusion promotes recurrence of hepatocellular carcinoma after hepatectomy [J]. Surgery, 1994; 115(3)∶303.
55. Chau GY, Lui WY, Tsay SH, et al. Prognostic significance of surgical margin in hepatocellular carcinoma resection: an analysis of 165 Childs’ A patients [J]. J Surg Oncol, 1997; 66(2)∶122.
56. Poon RT, Fan ST, Ng IO, et al. Significance of resection margin in hepatectomy for hepatocellular carcinoma: A critical reappraisal [J]. Ann Surg, 2000; 231(4)∶544.
57. 徐立, 石明, 張亞奇, 等. 肝細胞癌手術切緣對患者術后復發與生存的影響 [J]. 中華腫瘤雜志, 2006； 28(1)∶47.
58. Shi M, Zhang CQ, Zhang YQ, et al. Micrometastases of solitary hepatocellular carcinoma and appropriate resection margin [J]. World J Surg, 2004; 28(4)∶376.
59. Wu CC, Ho YZ, Ho WL, et al. Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinoma: a reappraisal [J]. Br J Surg, 1995; 82(1)∶122.
60. 王槐志, 董家鴻, 王曙光, 等. 肝移植治療原發性肝癌 [J]. 實用臨床醫藥雜志, 2003； 7（1）∶27.
61. 張樹民, 曾昭沖, 孫菁, 等. 肝細胞肝癌肺轉移的預后因素分析 [J]. 實用腫瘤雜志, 2005； 20(5)∶395.
62. Nielsen OS, Munro AJ, Tannock IF. Bone metastases: pathophysiology and management policy [J]. J Clin Oncol, 1991; 9(3)∶509.
63. Rasmusson B, Vejborg I, Jensen AB, et al. Irradiation of bone metastases in breast cancer patients: a randomized study with 1 year follow-up [J]. Radiother Oncol, 1995; 34(3)∶179.
64. 周信達, 劉銀坤. 原發性肝癌復發轉移防治的臨床與基礎研究 [J]. 中國腫瘤, 2001； 10(2)∶65.
65. 梁安民, 莫欽國. 原發性肝癌的綜合治療——附607例報告 [J]. 癌癥, 2003； 23（2）∶104.
66. Ebara M, Okabe S, Kita K, et al. Percutaneous ethanol injection for small hepatocellular carcinoma: therapeutic efficacy based on 20-year observation [J]. J Hepatol, 2005; 43(3)∶458.
67. Lencioni R, Cioni D, Crocetti L, et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation [J]. Radiology, 2005; 234(3)∶961.
68. 賴東明, 羅葆明, 劉超, 等. 原發性肝癌術后復發的射頻和無水酒精治療 [J]. 中國普外基礎與臨床雜志, 2006； 13(2)∶167.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Comparison on Characteristics of Tumor Recurrence of Hepatocellular Carcinoma after Liver Transplantation and Hepatectomy

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