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        west china medical publishers
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        find Author "丁超" 2 results
        • Effects of Edaravone in Reversing Ischemia Reperfusion Injury of Liver

          目的研究依達拉奉影響肝臟缺血再灌注過程中TNF-α的表達情況,探討依達拉奉對肝臟缺血再灌注損傷的逆轉作用。 方法將80只Wistar大鼠編號,根據計算機產生隨機數字,前40為一組,后40為一組,分為實驗組和對照組2組,建立常溫下部分肝缺血再灌注損傷動物模型。 在肝臟缺血再灌注損傷開始前1 h和開始時對實驗組大鼠給予依達拉奉注射液10 ml,對照組則給予同等容量的生理鹽水。分別于再灌注后0、1、2及4 h測定肝臟脂質過氧化物酶(LPO)和肝臟谷草轉氨酶(AST) 濃度; 應用RT-PCR法檢測肝組織TNF-α mRNA含量,并測定肝組織和血清中TNF-α水平; 應用TUNEL染色法檢測缺血肝組織的細胞凋亡情況。結果再灌注后1、2及4 h,實驗組大鼠肝臟LPO及AST濃度均明顯低于對照組(Plt;0.001); 實驗組再灌注后1 h時肝組織TNF-α mRNA表達量、肝組織和血清TNF-α含量均明顯升高且達峰值,但均明顯低于對照組(Plt;0.05); 再灌注后各時相實驗組肝細胞凋亡率明顯升高,但均明顯低于對照組(Plt;0.05)。 結論依達拉奉能抑制氧化應激反應,從而降低肝缺血再灌注損傷; 并顯著減少炎性細胞因子TNF-α的產生,抑制炎性反應的發生,減少肝細胞的凋亡。

          Release date:2016-09-08 10:41 Export PDF Favorites Scan
        • Video-assisted thoracoscopic lung resection in tuberculosis treatment: A retrospective cohort study

          ObjectiveTo investigate the feasibility of video-assisted thoracoscopic surgery (VATS) lung resection in the treatment of tuberculosis.MethodsWe retrospectively analyzed the clinical data of 164 tuberculosis patients who underwent lung resection in Xi'an Chest Hospital from 2013 to 2017. Patients were divided into two groups according to the surgical procedure: a VATS group (85 patients, 56 males and29 females) and a thoracotomy group (79 patients, 52 males and 27 females). The clinical effect of the two groups was compared.Results Compared to the thoracotomy group, the VATS group had less operation time (151.59±76.75 min vs. 233.48±93.89 min, P<0.001), amount of intraoperative blood loss (200.00 ml vs. 600.00 ml, P<0.001), the postoperative drainage (575.00 ml vs. 1 110.00 ml, P=0.001), extubation time (4 d vs. 6 d, P<0.001) and hospital stay (13.00 d vs. 17.00 d, P<0.001). There was no statistical difference in postoperative complications (10 patients vs.17 patients, P=0.092) between the two groups. A total of 97 patients underwent lobectomy, including 36 of the VATS group and 61 of the thoracotomy group. The operation time (211.39±70.88 min vs. 258.20±87.16 min, P=0.008), the intraoperative blood loss (400.00 ml vs. 700 ml, P<0.010), the postoperative drainage (800.00 ml vs. 1 250.00 ml, P=0.001), extubation time (5.00 d vs. 8.00 d, P=0.002) and hospital stay (13.11±4.45 d vs. 19.46±7.74 d, P<0.010) in the VATS group were significantly better than those in the thoracotomy group. There was no statistical difference in postoperative complication rate (4 patients vs. 14 patients, P=0.147) between the two[1], groups.ConclusionCompared with conventional thoracotomy, VATS lung resection has obvious advantages in treatment of tuberculosis, which may be the preferred technique.

          Release date:2019-06-18 10:20 Export PDF Favorites Scan
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