ObjectiveTo investigate the relationship between neuroticism and functional gastrointestinal disorders using Mendelian randomized (MR). MethodsBased on the genome-wide association study data of neuroticism and 2 functional gastrointestinal disorders, i.e., functional dyspepsia (FD), and irritable bowel syndrome (IBS), appropriate single nucleotide polymorphisms (SNP) were extracted as instrumental variables, and inverse variance weighted (IVW) was applied as the main analysis method, and sensitivity analyses were performed by Cochran’s Q test, MR-PRESSO test, MR-Egger intercept, and leave one out analysis. Further two-step MR analyses were performed to examine the mediating effects of coffee intake, alcohol consumption, smoking, depression. ResultsThe univariable MR analysis showed that genetically determined neuroticism was positively causally associated with the risk of developing FD and IBS (FD: OR=1.448, 95%CI 1.057 to 1.983, P=0.021; IBS: OR=1.705, 95%CI 1.210 to 2.403, P=0.002). Cochran's Q-test, MR-Egger intercept, MR-PRESSO did not observe significant heterogeneity or horizontal pleiotropy. Leave-one-out analyses also did not find a large effect of individual SNPs on the overall results. Multivariable MR analyses showed that the association between neurotic personality and elevated risk of FD and IBS prevalence persisted even after adjusting for other confounders. Further two-step MR mediation analyses revealed that depression partially mediated this effect, with mediation proportions of 59.41% (95%CI 5.69% to 113.12%) and 67.53% (95%CI 31.55% to 103.51%), respectively. ConclusionThere is a degree of causal association between neuroticism and FD and IBS, and depression may play an important mediating role in this association.
Objective
The aim of this research was to explore the relationship between type D personality and symptom duration/emergency admissions/mental health status/quality of life (QOL) in Chinese rectal cancer patients.
Methods
Rectal cancer patients who were treated in our hospital form Oct. 2010 to Oct. 2012 were selected prospectively, and then their type D personality was measured with the 14-item Type D Personality Scale (DS14). Mental health status was measured with the Hospital Anxiety and Depression Scale (HADS). The QOL was assessed longitudinally by using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-CR38 questionnaires at the baseline and 6 months after diagnosis. Comparison between the type D personality group and non-type D personality group in social-demographic characteristics, clinicopathological features, mental health status, and QOL was performed.
Results
Of the 596 patients (92%) who responded, 131 patients (22%) had type D personality. ① Compared with non-type D personality group, the proportions of patients with duration of symptoms ≥1 month, without medical insurance, and emergency admissions in type D personality group were all higher, as well as the poor economic situation and more complication (
P<0.050). ② EORTC QLQ-C30. At the baseline, scores of role function, emotional function, cognitive function, social function, and overall health status in type D personality group were all lower than those of non-type D personality group (
P<0.050), but scores of fatigue, constipation, and financial difficulties in type D personality group were all higher than those of non-type D personality group (
P<0.050). In 6 months after diagnosis, scores of role function, emotional function, cognitive function, social function, and overall health status in type D personality group were all lower than those of non-type D personality group (
P<0.050), but scores of fatigue, insomnia, constipation, and financial difficulties in type D personality group were all higher than those of non-type D personality group (
P<0.050). ③ EORTC QLQ-CR38. At the baseline, score of expectation for the future in type D personality group was lower than that of non-type D personality group (
P<0.001), but score of urinary problems in type D personality group was higher in type D personality group than that of non-type D personality group (
P<0.001). In 6 months after diagnosis, scores of expectation for the future and sexual function in type D personality group were both lower than those of non-type D personality group (
P<0.050), but scores of urinary problems, gastrointestinal symptoms, male sexual dysfunction, and excretion difficulties in type D personality group were all higher than those of non-type D personality group (
P<0.050). ④ At the baseline and 6 months after diagnosis, the incidences of anxiety and depression in type D personality group were all higher than those of non-type D personality group at the same time point (
P<0.001). In type D personality group, the incidences of anxiety and depression in 6 months after diagnosis were both higher than baseline (
P<0.001).
Conclusion
Type D personality may be a general vulnerability factor to screen for subgroups at risk for longer SD and emergency admissions in clinical practice of rectal cancer patients, and it was associated with poor QOL and poor mental health status.
Objective To investigate the correlation between OPRM1 A118G gene polymorphism and Eysenck personality type and pain sensitivity. Methods The surgical patients who were transferred from Department of Emergency Medicine to Department of General Surgery of Luzhou People’s Hospital between January 2018 and December 2020 were selected. Before surgery, Eysenck Personality Questionnai (EPQ) was used to investigate the patient’s personality type, and the pain threshold and pain tolerance threshold were determined by electric stimulation instrument. The OPRM1 A118G genotype of peripheral venous blood was detected by polymerase chain reaction-restriction fragment length polymorphism analysis technique. Patients were divided into wild homozygous (A/A) group, mutant heterozygous (A/G) group and mutant homozygous (G/G) group according to the typing results. The general condition, pain sensitivity, EPQ score, difference of Eysenck personality type and correlation between Eysenck personality type and pain sensitivity were analyzed. Results A total of 356 patients were enrolled, including 174 in A/A group, 136 in A/G group and 46 in G/G group. The mutation rate of OPRM1 A118G gene was 32.00%. There were statistically significant differences in pain sensitivity (pain threshold, pain tolerance threshold) and scores of introverted and extraverted, neurotic and dissemble personality types among three groups (P<0.05). There were significant differences in introverted and extraverted and psychotic personality types among the three groups (P<0.05). There were significant differences in pain threshold and pain tolerance threshold among different introverted, extraverted and psychotropic personality types (P<0.05). Conclusion Both OPRM1 A118G gene polymorphism and Eysenck personality type have influence on pain sensitivity, and there is a correlation between them.
The research shows that personality assessment can be achieved by regression model based on electroencephalogram (EEG). Most of existing researches use event-related potential or power spectral density for personality assessment, which can only represent the brain information of a single region. But some research shows that human cognition is more dependent on the interaction of brain regions. In addition, due to the distribution difference of EEG features among subjects, the trained regression model can not get accurate results of cross subject personality assessment. In order to solve the problem, this research proposes a personality assessment method based on EEG functional connectivity and domain adaption. This research collected EEG data from 45 normal people under different emotional pictures (positive, negative and neutral). Firstly, the coherence of 59 channels in 5 frequency bands was taken as the original feature set. Then the feature-based domain adaptation was used to map the feature to a new feature space. It can reduce the distribution difference between training and test set in the new feature space, so as to reduce the distribution difference between subjects. Finally, the support vector regression model was trained and tested based on the transformed feature set by leave-one-out cross-validation. What’s more, this paper compared the methods used in previous researches. The results showed that the method proposed in this paper improved the performance of regression model and obtained better personality assessment results. This research provides a new method for personality assessment.
Objective To study the personality characteristics of Chongqing pupils and the influencing factors. Methods A cross-sectional survey with Eysenck Personality Questionnaire (EPQ, Children’s Version) and Social Support Rating Scales was carried out to investigate 1 110 pupils in Grade 4 to 6 from 7 schools in Chongqing who were selected by means of cluster sampling. Then the score of each EPQ factor was compared with the norm, and the major influencing factors were screened. Results a) The score of each EPQ factor was compared with the national norm. The scores of the introversion and extroversion, and psychoticism in both gender groups aged 9 to 12, the concealment tendency in the girl group aged 9 to 11, and the neuroticism in both gender groups aged above 11, the boy group aged 9 to 10, and the girl group aged above 12 were all lower than those of the norms (Plt;0.05), but the scores of the concealment tendency in the boy groups aged above 9 and above 11, and in the girl group aged above 12 were higher than those of the norms (Plt;0.05); b) The introversion and extroversion were influenced by the factors of residence, grade, family quarrel, praise and encouragement from parents, being praised by teachers in charge, subjective support and the degree of using support. The neuroticism was influenced by the factors of family quarrel, pressure of homework from parents, praise and encouragement from parents, beating and scolding by family, burden of study, and the degree of using support. The psychoticism was influenced by the factors of gender, residence, one-child family nurture, praise and encouragement from parents, beating and scolding by family, criticism by teachers in charge, burden of study, objective support, and the degree of using support. The concealment tendency was influenced by the factors of gender, grade, family quarrel, pressure of homework from parents, praise from teachers in charge, burden of study, subjective support, and the degree of using support. Conclusion The personality characteristics of pupils in Chongqing tend to be introversion and stability in general, which are influenced by various factors such as individual, family and school.
ObjectiveTo explore the personalistic characteristics of patients with migraine and medication-overuse headache (MOH), and to provide scientific evidence for mental treatment of these patients.
MethodsThe subjects were divided into three groups:migraine group, MOH group, and health group.Patients with migraine or MOH, admitted to the Deyang People's Hospital from March 2012 to March 2014, were selected in this study.In addition, healthy volunteers were selected as controls at the same time.Data were collected through the Minnesota multiphasic personality inventory computer testing software, and differences of personalistic characteristics were compared among patients with migraine, MOH and controls.
ResultsPatients with migraine and MOH had mental problems and the occurrence rate of psychological problems of MOH patients was significantly higher than that of migraine patients (χ2=6.055, P=0.014).Migraine patients showed higher scores of hypochondriasis, depression, hysteria, psychasthenia, hypomania than controls (P < 0.01).Compared with migraine patients, the scales of hypochondriasis, depression, hysteria, paranoia, schizophrenia were higher in MOH patients (P < 0.01).
ConclusionsPatients with migraine and MOH have personalistic and psychological problems.Early screening of personalistic characteristics and mental interventions may improve the clinical outcome of patients with migraine or MOH.
