Objective To observe the clinical and pathological characteristics of choroidal metastatic carcinoma from lung carcinoma.Methods The clinical and pathological data of 6 patients with choroidal metastatic carcinoma from lung carcinima were analysed retrospectively.Results All the 6 patients had severe visual impairment, including 3 with severe ophthalmalgia. Flat neoplasm were seen in the posterior pole of the eyes in all the 6 patients and retinal detachment were found in 5 patients. Fundus fluorescein angiography (FFA) examination had been performed on 1 patient and blocked fluorescence and hyperfluorescence were seen in the lesion with pinpoint fluorescein leakage loop around it. CT examination had been performed on 3 patients and the shadow of flat homogenous tumor was seen. MRI examination had been performed on 1 patient and high signal intensit ies on T1W and low signal intensities on T2W were found. In all the 6 patients with primary lung carcinoma, 5 were diagnosed with adenocarcinoma and 1 with cellule carcinoma through pathological examination, and 5 patients were diagnosed with choroidal metastatic carcinoma from adenocarcinoma and 1 with choroidal metastatic carcinoma from cellule carcinoma through pathological examination.Conclusion Rapid visual acuity decrease, severe ophthalmalgia, flat neoplasm in ocular fundus and secondary retinal detachment are the main clinical characteristics of the choroidal metastatic carcinoma from lung carcinoma. Most histopathologica l manifestations of the metastatic carcinoma like that of the primary focus, and adenocarninoma is the most common histoclassification. (Chin J Ocul Fundus Dis，2003，19：333-404)
Purpose
To investigate nucleoside diphosphate kinase (NDPK ) expression of tumor metastasis suppressor gene nm23 in heterotransplanted model of retinoblastoma(RB) in nude mice，and analyse the correlation between the expression of nm23 gene and the formation and progression of heterotran splanted RB．
Methods
SP immunohistochemical method was used to detect the expression of nm23 gene product NDPK in 20 tumors of heter otransplanted RB model and normal retinal tissue．
Results
The negative staining of nm23/ NDPK was found in normal retinal tissue , whereas 100% expression rate in RB tumors with positive number of 48.73plusmn;2.37． No statistical significance of the expression of nm23/ NDPK was observed between the intraocular growth phase （I～Ⅲ grade） and invasive phase （ Ⅳ～Ⅴ grade）in heterotransplantedRB tumors．
Conclusion
The function of nm23 gene as a tumor metastasis suppressor in heterotra nsplanted RB tumors was less prominent ,but it may play a role in carcinogen esis and progrssion of RB and may predict poor prognosis．
(Chin J Ocul Fundus Dis, 2001.17:47-49)
PURPOSE: To evaluate the value of cellular DNA content and proliferative activity in an attempt to distinguish between benign and malignant or to estimate malignant potential of conjunetival and uveal pigmental tumors. METHODS :Cellular DNA content ,proliferative index(PI) and s-phase fraction(SPF)from uveal malignant melanomas (UMM),conjunctival nevi (CN) and malignant melanomas (CMM) were measured by flow cytometry(FCM). RESULTS:Seven cases of CN were diploid,aneuploid incidence of 7 cases of CMM and 39 cases of UMM was 57.14% and 74.36% respectively. SPF and PI in CMM were significantly higher than SPF (Plt;0.05) and PI(Plt;0.01)in CN;DNA index (DI) and aneuploid incidence in UMM were related to different pathological category (Plt;0.01). In 19 cases of UMM,there was a significantly positive correlation between DI and argyrophilic nucleolar organizer regions (AgNORs) asssociated proteins areas (Plt;0.01).
CONCLUSIONS: It is suggested that aneuploid might be a characteristic feature of CMM and UMM ;SPF and PI might be used as adjunctive indexes in distinguishing between benign and malignant conjunctival melanomas :DI and silver-stained areas replenish each other to provide tumor biological information in different aspects.
（Chin J Ocul Fundus Dis,1996,12: 94- 97）
