Plasma cortisols in 18 abdominal emergency patients and 20 planned-operation patients were examined. The result showed that cortisols in planned-operation patients were increased after their operations. On the other hand, plasma cortisols in emergency patients were higher in preoperative period than that in the postoperative period. There were no furher increase after operations. The changes of plasma cortisols between two kinds of patients were very different. This means that stress reactions in the patient with acute abdomen can be reduced by early operations.
Objective To investigate the effect of epristeride on 5-alpha-reductase activity and androgen receptor levels in prostate tissue. Methods Forty patients with benign prostate hyperplasia were randomly divided into the trial group and the control group with 20 in each group. Patients in the trial group were administered oral epristeride and terazosin, while those in the control group were given just terazosin. All patients underwent trans-urethral resection of the prostate after two weeks, and then the 40 samples of prostate were tested immunohistochemically for 5-alpha-reductase activities and androgen receptor levels. Results The 5-alpha-reductase in prostate tissue was not stained or lightly stained in the trial group, while it was heavily stained in the control group. The androgen receptor in prostate tissue was heavily stained in both groups. Conclusion Oral epristeride can inhibit the activity of 5-alpha-redutase in prostate tissue, but it has no obvious effect on the androgen receptor level in prostate tissue.
