ObjectiveThe aim of this study was to understand the relationship between IQ and glucose metabolism in brain cells in a wide variety of epilepsy subjects.
MethodsThe study participants were 78 children with epilepsy and 15 healthy children for comparison. All participants were administered the Chinese Wechsler Intelligence Scale for Children (C-WISC). The verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ) and full scale intelligence quotient (FIQ) were compared between epileptic children and typically developing children. 78 patients underwent interictal positron emission computed tomography (PET) using 2-deoxy-2[18F]fluoro-D-glucose (FDG) as the tracer for evaluating brain glucose metabolism.
ResultsVIQ, PIQ and FIQ based on the C-WISC were significantly lower in epileptic children than those in the healthy comparison group (P < 0.001, P=0.001 and P < 0.001, respectively). The IQ of patients with normal metabolism, unifocal abnormal hypometabolism and multifocal abnormal hypometabolism determined by PET differed significantly. The extent of the abnormal hypometabolism was negatively correlated with the FIQ (rs=-0.549, P < 0.001). In patients with lateralized hypometabolism based on PET, the VIQ/PIQ discrepancy (︱VIQ-PIQ︱≥15 points)scores differed significantly between the left hemisphere abnormal hypometabolism and right hemisphere abnormal hypometabolism subgroups, being negative values in the left and positive values in the right subgroups(P=0.004).
ConclusionsBrain metabolic abnormalities are correlated with IQ, and perfoming interictal PET along with C-WISC can better assess the extent of severity of cognitive impairment and VIQ/PIQ discrepancy.
ObjectiveTo understand the prevention and control effects of iodine deficiency disorders and its progression trend of disease condition in Chongqing.
MethodsOne primary school was randomly selected as longitudinal surveillance sites in each of 4 counties in Chongqing city. A total of 90 children aged 8 to 10 years were randomly selected in each school with goiter, salt iodine, urinary iodine and intelligence detected. Meanwhile, in the four sites, urinary iodine of pregnant women and nursing women was tested. The goiter was examined by B-ultrasonograghy, urinary iodine by Ce arsenic acid digestion, and salt iodine by direct drop methods.
ResultsA total of 360 children aged 8 to 10 years were investigated surveillance sites. The total goiter rate was 5.28%. There was no significant difference in the total goiter rate among different counties (P > 0.05). The median of iodized salt was 26.65 mg/kg. The coverage rate of iodized salt, consumption rate of qualified iodized salt and intake rate of qualified iodized salt was 99.72%, 91.09% and 97.04%, respectively. The medians of urine iodine of children, pregnant and nursing women were 238.15 μg/L, 218.15 μg/L and 252.90 μg/L, respectively. The cases with urine iodine lower than 100 μg/L accounted for 11.94%, 32.93% and 13.75%, respectively. The cases with urine iodine above 300 μg/L accounted for 34.17%, 13.41% and 43.75%, respectively. The mean intelligence quotient of children was 112.57.
ConclusionThe goiter rate of schoolchildren in Chongqing city is relatively high and the population's iodine nutrition level is stable. However, the shortage and overdose of iodine still exist in Chongqing city.
