west china medical publishers

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west china medical publishers

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尿酸與神經變性疾病

West China Medical Journal 2014, 29(4): 791-794

目前研究發現尿酸水平與一些神經變性疾病，如帕金森病（PD）、阿爾茨海默病（AD）及肌萎縮側索硬化（ALS）的發病呈負相關，較高的血及腦脊液尿酸水平可延緩PD、亨廷頓病、多系統萎縮的進展，而低尿酸水平是否促進ALS和AD病情進展還存在爭議。尿酸主要通過抗氧化應激作用發揮對神經元的保護作用。調節尿酸水平可能成為神經變性疾病治療的新策略。

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