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Advances in artificial intelligence in prediction of atrial fibrillation

Atrial fibrillation (AF) is one of the most common arrhythmias. Today, there are a large number of AF patients worldwide, and incidence increases with the increase of age. However, the current diagnosis rate of AF via auxiliary examination is relatively low. In view of the widespread application of artificial intelligence (AI) in the medical field, the diagnosis of AF using AI has also become a research hotspot. This article briefly introduces the relevant aspects of AI and reviews the application of AI in AF prediction.

Research Progress in Cell Transplantation for Treatment of Myocardial Infarction

The capacity for self-regeneration of the adult heart is very limited, conventional therapies cannot solve the loss of cardiomyocytes in the infarcted heart leads to continuous ventricular remodeling. Cell transplantation therapy is emerging as a novel approach for myocardial repair over conventional therapies. Various types of cell transplantation have improved cardiac function and angiogenesis in animal models and clinical settings. The safety and feasibility of some clinical trials have been initiated. In this review, we summarize the advantages and limitations of different cell types proposed for cell transplantation in myocardial infarction and give an overview of the clinical trials using this novel therapeutic approach in patients with myocardial infarction.

Research and clinical application progress of cardiac mapping in the electrophysiological mechanism of atrial fibrillation

Atrial fibrillation is one of the most common arrhythmia. Cardiac mapping technology, an important method to study the electrophysiological mechanism of atrial fibrillation, can determine the abnormal origin and record the distribution and transmission way of these atrial electrical signals. This technology offers a new way for research the electrophysiological mechanism of atrial fibrillation. The purpose of this study is to review the research progress of cardiac mapping in the electrophysiological mechanism of atrial fibrillation and clinical application.

Histone deacetylase: a potential target for the treatment of atrial fibrillation

Atrial fibrillation is a common arrhythmia associated with high mortality and morbidity, and the current treatment of atrial fibrillation is still limited. Histone deacetylase (HDAC) plays an important role in the pathophysiology of cardiovascular disease and promotes the occurrence of atrial fibrillation. Inhibition of HDAC may be a new therapeutic strategy through the regulation of atrial remodeling. Therefore, we reviewed the research progress of the HDAC and atrial fibrillation.

起源于二尖瓣瓣環的心臟粘液瘤一例

心內直視下射頻消融改良迷宮術治療心房顫動

目的 總結心內直視下射頻消融改良迷宮手術治療心房顫動的臨床經驗。 方法 2005年5月～2006年8月在心內直視手術同期采用射頻消融改良迷宮手術治療心房顫動30例，術前診斷風濕性心臟病26例，二尖瓣關閉不全3例，冠心病1例。手術采用Cardioblate TM沖洗式射頻消融系統，每例患者分別應用單極系統和雙極系統，按照迷宮手術線路分別于左、右心房行心內膜射頻消融手術，并切除左、右心耳，同期完成相應的心臟手術。 結果 手術均順利完成，射頻消融手術時間30.5±12.6 min。術后死亡1例，其余29例順利出院。術后當天21例患者（70.0％）轉為竇性心律。29例患者出院后隨訪7.6±4.8個月，24例（82.8%）為竇性心律,5例（17.2％）為心房顫動或房室結性心律。 結論 心內直視下射頻消融改良迷宮手術治療心房顫動簡單、有效，具有良好的臨床應用前景。

華法林抗凝過量致自發性后腹膜出血一例

流動對兔動脈縮窄區域內皮細胞形態的影響

目的 在體考察不同流場環境中血管內皮細胞形態學和完整性的改變,及其與流場的空間相關性. 方法 將10只大耳白兔分成動脈縮窄組和對照組,建立兔頸總動脈環縮狹窄,使用脈沖多普勒超聲系統考察縮窄下游的湍流流場及對側血管的層流流場;用掃描電子顯微鏡探測內皮細胞(ECs)計數、形狀指數和定向角等形態學指標. 結果 縮窄下游的湍流流場中ECs大量脫落,細胞下基質和膠原組織暴露,ECs變形,無明顯定向性.越遠離縮窄,ECs的殘留率越高,細胞也逐漸重新建立了定向性. 結論 縮窄血管下游的湍流流動是導致血管ECs形態結構異常和損傷的重要原因.

肺動脈高壓靶向藥物在慢性血栓栓塞性肺動脈高壓中的應用現狀

升主動脈不接觸技術在非體外循環冠狀動脈旁路移植術中的應用

目的 總結升主動脈不接觸技術在非體外循環冠狀動脈旁路移植術(offpump CABG)中的應用經驗,以減少術后腦卒中的發生。 方法 回顧分析31例合并升主動脈粥樣硬化冠心病患者的臨床資料，男25例，女6例；年齡58~78歲，平均年齡71.3歲。5例聯合應用offpump CABG和經皮腔內冠狀動脈成形術（PTCA）雜交技術治療，其余26例均采用常規胸骨正中切口徑路行offpump CABG。9例雙側乳內動脈原位移植；16例以左乳內動脈為惟一的供血來源，大隱靜脈或橈動脈近端與左乳內動脈端側吻合；1例大隱靜脈近端吻合到無名動脈。所有患者主動脈根部均無吻合口。 結果 5例“雜交”手術患者共經PTCA植入支架6枚，26例胸骨正中開胸患者移植血管74支（2~4支/例），全組患者手術均順利完成，痊愈出院，無院內死亡。術后心絞痛消失24例，明顯緩解7例。發生心房顫動2例，行二次開胸手術1例，肺部感染2例，切口感染1例，無圍術期心肌梗死和神經系統并發癥發生。隨訪29例，隨訪3個月~3年，失訪2例。隨訪期間無死亡，1例行“雜交”手術患者術后1年心絞痛再發，其余28例患者生活質量良好，無神經、精神系統并發癥發生。 結論 對合并升主動脈粥樣硬化的冠心病患者，采用offpump CABG結合升主動脈不接觸技術治療，可有效地減少術后神經系統并發癥的發生，臨床效果滿意。