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west china medical publishers

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find Author "王善政" 1 results

共刺激分子B7mRNA在大鼠缺血-再灌注損傷肺組織中的表達

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2002, 9(1): 68-69

目的進一步驗證B7-CD28共刺激通路在肺缺血-再灌注損傷中的作用. 方法復制大鼠原位肺熱缺血-再灌注模型,將40只Wistar大鼠隨機分為假手術組、缺血30分鐘再灌注組,利用多聚酶鏈反應(RT-PCR)半定量技術檢測缺血-再灌注不同時相肺組織中共刺激分子B7的mRNA表達水平. 結果正常和缺血肺組織中B7mRNA的表達處于極低水平,再灌注后肺組織中B7mRNA的表達開始逐漸升高,并于再灌注后48小時達高峰. 結論缺血-再灌注后肺組織內B7mRNA的轉錄水平升高,進一步闡明了肺缺血-再灌注損傷與共刺激分子B7之間的聯系.

Release date：2016-08-30 06:31 Export PDF Favorites Scan

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