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        west china medical publishers
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        find Author "王如文" 26 results
        • 兒童食管腐蝕傷的外科治療

          目的 探討兒童食管腐蝕傷后瘢痕狹窄的預防和治療措施. 方法 1988年5月~2000年5月收治食管腐蝕傷兒童32例,早期采用食管擴張3例,食管腔內置管8例;后期采用結腸代食管14例,胃代食管5例,頸闊肌皮瓣修復2例. 結果 全組手術治愈31例,死亡1例;術后發生并發癥9例,其中吻合口瘺6例,吻合口狹窄2例,頸部瘺1例,均治愈.28例隨訪1~12年,均恢復進普通飲食;3例失訪. 結論 早期食管腔內置管對預防食管腐蝕傷后瘢痕狹窄有明顯療效,結腸代食管術是后期食管重建的主要手段,主動脈弓以下瘢痕食管可切除用胃重建,頸闊肌皮瓣修復術是治療頸部局限性食管狹窄的理想方法.

          Release date:2016-08-30 06:31 Export PDF Favorites Scan
        • 外科手術取食管異物15例

          目的探討外科手術取食管異物的適應證及手術方法。方法采用外科手術摘除尖銳食管異物15例,其中頸段5例,胸段10例。5例頸段異物均合并膿腫,行膿腫切開引流同時取出異物;4例胸段異物摘除后施行改良食管腔內置管術;余6例取出異物后分層縫合食管切口。結果全組無死亡。4例施行食管腔內置管,術后1~2周中毒癥狀緩解,3~5周拔管后食管X線鋇餐造影檢查無穿孔或狹窄。1例切開食管取異物后發生右側膿胸,術后第8d行膿胸廓清術及改良食管腔內置管,1個月后治愈;其余患者術后7~10d恢復經口進食。結論已穿透食管的金屬異物和食管鏡摘除易引起穿孔的尖銳異物應采用外科手術治療,改良食管腔內置管對縱隔感染嚴重、無法修補的穿孔愈合是有幫助的。

          Release date:2016-08-30 06:22 Export PDF Favorites Scan
        • 胸腺瘤表皮生長因子受體、增殖細胞核抗原、Bcl-2和Bax表達及臨床意義

          目的 探討胸腺瘤表皮生長因子受體(EGFR)、增殖細胞核抗原(PCNA)、Bcl-2和Bax的表達與胸腺瘤臨床病理特征的關系及臨床意義. 方法 應用免疫組織化學鏈霉素親生物蛋白-過氧化酶(S-P)法檢測46例胸腺瘤患者EGFR、PCNA、Bcl-2和Bax的表達. 結果 胸腺瘤EGFR陽性表達率為71.7%,PCNA標記指數為4.00%±1.87%,Bcl-2、Bax陽性率分別為41.3%、15.2%.EGFR表達與胸腺瘤Masaoka分期、腫瘤性質有明顯關系,EGFR陰性者術后生存率顯著高于陽性者(P=0.005).PCNA標記指數和Bcl-2與胸腺瘤腫瘤性質有明顯關系,Bcl-2陰性者術后生存率顯著高于陽性者(P=0.002).EGFR、PCNA、Bcl-2和Bax表達均與胸腺瘤組織學類型、是否合并重癥肌無力無明顯關系. 結論 EGFR與胸腺瘤的發生、發展有關,可作為Masaoka分期的補充推測預后.Bcl-2與胸腺癌發生有關,可作為胸腺癌的標記物用于鑒別診斷.

          Release date:2016-08-30 06:32 Export PDF Favorites Scan
        • 電視胸腔鏡經右胸前側徑路胸腺切除治療重癥肌無力

          目的 探討電視胸腔鏡手術(VATS)胸腺切除治療重癥肌無力的效果. 方法 10例重癥肌無力患者采用VATS經右胸前側徑路行胸腺切除及縱隔脂肪清掃(VATS組),并與20例胸骨劈開胸腺切除(胸骨劈開組)相對照. 結果 VATS組中9例順利完成手術,1例因電凝鉤傷及頭臂靜脈干而中轉開胸止血;全組無術后死亡及危象發生;手術時間、術后住院時間均較胸骨劈開組明顯縮短. 結論 VATS經右胸前側徑路行完全胸腺切除是可行的,且具有創傷小、恢復快等優點,可在臨床進一步應用.

          Release date:2016-08-30 06:32 Export PDF Favorites Scan
        • Early radiological diagnostic value of closed chest trauma in rabbits

          Objective To explore the early diagnostic value of single photon emission computed tomography(SPECT), thoracic computed tomography(CT),and chest X-ray for closed chest trauma. Methods To establish the animal model of unilateral chest impact trauma,to adopt SPECT, thoracic CT, and chest X-ray for early diagnosis of closed chest trauma,and to compare these findings with postmortem examination. Results Thirty minutes after blunt chest trauma, the region of interesting (ROI) between traumatized lung and the heart (ROI2/ROI1) immediately increased to the peak six hours after trauma; on the contralateral lung, the ratio (ROI3/ROI1) increased slowly and reached the peak after six hours, these ratio was still smaller than that of the traumatized lung. These differences were significant (Plt;0.01). Conclusions Chest X-ray is still the most fundamental diagnostic method of chest trauma,but it was thought that the patients of severe chest trauma and multiple injuries should be examined early by thoracic CT. Radionuclide imaging have more diagnostic value than chest X-ray on pulmonary contusion. The diagnostic sensibility to pulmonary contusion of thoracic CT is superior to conventional radiograph,but thoracic CT is inferior to SPECT on exploring exudation and edema of pulmonary contusion. Thoracic CT is superior to conventional radiograph on diagnosis of chest trauma,therefore patients of severe chest trauma and multiple injuries should be adopted to thoracic CT examination at emergency room in order to be diagnosed as soon as possible.

          Release date:2016-08-30 06:28 Export PDF Favorites Scan
        • 頸闊肌皮瓣修復或重建頸部食管缺損術后并發癥探討

          目的 探討頸闊肌皮瓣重建或修復頸部食管缺損術后常見并發癥的預防和治療。方法 對我科1989年6月至2001年6月采用雙側頸闊肌皮瓣重建頸段食管缺損15例,單側頸闊肌皮瓣修復頸段食管缺損23例進行回顧性分析。結果 全組無手術死亡,肌皮瓣全部成活,6例發生吻合口瘺,更換敷料后愈合;吻合口狹窄2例,1例經擴張后治愈,另1例經再次手術恢復,所有患者均能正常經口進食。結論 頸闊肌皮瓣重建或修復下咽及頸段食管缺損,具有創傷小、轉移就近方便、能一期完成手術、術后并發癥少等優點,值得在臨床推廣應用。

          Release date:2016-08-30 06:34 Export PDF Favorites Scan
        • Analysis of Postoperative Complications and Cause of Death for Carcinoma of Esophagus

          Objective To analyse postoperative complications and cause of death for carcinoma of esophagus. Methods A retrospective study was undertaken for data of 2 085 patients with esophageal carcinoma from 1963 to 2003, the patients were divided into group A (332 cases,1963-1983), group B(727 cases,1984-1993) and group C (1 026 cases,1994-2003) by time. The postoperative complications and cause of death were analysed. Results Resectability rate, incidence rate of postoperative complications and hospital mortality were 90.84%(1 894/2 085), 11.61% (242/2 085) and 1.82% (38/2 085) respectively. Main complications were pulmonary complications (3.93%,82/2 085),anastomotic leak (3.12%,59/1 894), and cardiovascular disease (1.29%,27/2 085). Resectability rate of group B and group C were higher than that of group A, incidence rate of postoperative complications and hospital mortality of group B and group C were lower than that of group A. Resectability rate of group C were higher than that of group B, incidence rate of postoperative complications except pulmonary complications and hospital mortality of group C were lower than those of group B. Conclusions Pulmonary complications and anastomotic leak are main postoperative complications and cause of hospital death for carcinoma of esophagus, they are decreasing in recent years because of the progress of anesthetic,surgical technique and perioperative management.

          Release date:2016-08-30 06:25 Export PDF Favorites Scan
        • 頸闊肌皮瓣在食管腔內病理變化與修復重建頸段食管的臨床應用

          目的 觀察頸闊肌皮瓣修復頸段食管后在食管腔內的病理變化及修復重建頸段食管的臨床療效.方法 建立頸闊肌皮瓣修復頸段食管缺損的家犬模型12只,定期活殺取材,對頸闊肌皮瓣和肌皮瓣食管吻合部進行大體、光學顯微鏡、電子顯微鏡和免疫組織化學觀察.測定頸闊肌皮瓣食管吻合部的抗張強度(WBS)、Ⅰ型前膠原(PCⅠ)及Ⅲ型前膠原(PCⅢ)含量的變化.隨訪臨床應用頸闊肌皮瓣的33例患者,評價其臨床療效.結果 頸闊肌皮瓣在食管腔內仍有毛發生長,上皮保持角化,肌皮瓣上皮有"皮膚型"角蛋白表達,無"食管型"角蛋白表達.術后1個月內肌皮瓣食管吻合部的愈合比皮膚傷口延遲7~14天,術后6個月肌皮瓣食管吻合部有疤痕增生.肌皮瓣食管吻合部堿性成纖維細胞生長因子和轉化生長因子β1開始表達的時間較正常皮膚傷口晚,表達的強度減弱,表達的持續時間延長.肌皮瓣食管吻合部WBS和PCⅠ含量在1個月內明顯低于皮膚傷口,術后3個月無明顯差異,術后6個月PCⅠ含量明顯高于皮膚傷口和正常皮膚,PCⅢ含量達最大值的時間比皮膚傷口延遲.肌皮瓣在食管腔內無潰瘍、毛發生長和癌變,頸闊肌皮瓣修復重建頸段食管術后患者吞咽功能恢復滿意.結論 術后6個月內,頸闊肌皮瓣在食管腔內無明顯變化.肌皮瓣食管吻合部早期愈合延遲、后期疤痕增生可能是肌皮瓣修復重建食管后吻合口瘺和狹窄發生率高的重要原因.頸闊肌皮瓣是修復重建頸段食管的較好方法之一.

          Release date:2016-08-30 06:35 Export PDF Favorites Scan
        • Analysis of thymectomy for myasthenia gravis in 236 patients

          Objective To summarize experiences of surgical treatment and long-term results of myasthenia gravis (MG). Methods Two hundred thirty-six patients underwent thymectomy for MG in our department from Jan.1978 to Dec. 2002. The perioperative management, relative factors of postoperative crisis and long-term results were analysed. Results In 236 patients postoperative crisis took place in 44 cases accounted for 18.6%. The occurrence of postoperative crisis was related to preoperative management, modified Osserman clinical classification and combination with thymoma. Three cases died in the postoperative periods. Among them, one died of acute respiratory distress syndrome induced by aspiration and the other died of crisis. The effective rate in 1, 3, 5 years was 84.6%, 91.0% and 89.0% respectively. Conclusions Thymectomy for MG is safe and effective. Delayed extubation could decrease the needs of tracheotomy in patients with high risk factors for postoperative crisis. The partial sternotomy approach is less traumatic but the long-term effects of surgery are identical to those reported by the most authors.

          Release date:2016-08-30 06:27 Export PDF Favorites Scan
        • 食管腐蝕傷的外科治療

          目的總結食管腐蝕傷的外科治療經驗。方法149例食管腐蝕傷患者,除7例行保守治療外,其余142例采用外科手術治療(其中11例在我科行2次手術)。采用改良食管腔內置管28例,于腐蝕傷后6個月行食管重建術96例(結腸代食管71例、胃代食管25例),頸闊肌皮瓣修復頸段食管局限性狹窄或吻合口狹窄17例,其他手術12例。結果7例保守治療的患者中死亡2例,余5例1度燒傷患者未形成瘢痕狹窄。手術治療142例中,行結腸代食管術患者死亡5例,發生頸部吻合口瘺14例,頸部吻合口狹窄8例,膿胸1例。改良食管腔內置管28例,23例成功,再狹窄5例經再次手術或食管擴張治愈。存活患者均恢復正常進食。結論改良食管腔內置管可預防食管瘢痕狹窄;食管狹窄位于主動脈弓平面及以上時,曠置瘢痕食管行結腸代食管術,而位于主動脈弓平面以下時,切除瘢痕食管采用胃代食管術重建食管;頸闊肌皮瓣可用于修復頸段食管狹窄或吻合口狹窄。

          Release date:2016-08-30 06:26 Export PDF Favorites Scan
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