【摘要】 目的 探討成都市成華區中老年人群血脂水平、分布特點及其與胰島素抵抗指數（HOMA-IR）的關系。 方法 2007年5月在此區中老年（50~79歲）人群中隨機抽取672人進行心血管危險因素研究調查，對其血脂水平及HOMA-IR進行統計分析。 結果 人群當中①女性各血脂項目的水平均比男性高，其中總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）的差異有統計學意義（Plt;0.05）；②三酰甘油（TG）升高的比例較高，其中男性為30.0%，女性為27.6%；大部分人群HDL-C、低密度脂蛋白膽固醇（LDL-C）水平處于合適范圍，HDL-C降低的比例為6.0%，LDL-C升高的比例為7.3%；③隨著TG水平的升高、HDL-C 水平的降低，HOMA-IR呈升高趨勢；LDL-C水平的升高，HOMA-IR呈升高趨勢，僅在女性人群中差異有統計學意義（Plt;0.05），在男性人群中差異無統計學意義；④TG與HOMA-IR呈正相關，相關系數為0.185（P=0.000）；HDL-C與HOMA-IR呈負相關，相關系數為-0.145（P=0.000）。LDL-C與HOMA-IR呈正相關，相關系數為0.099（P=0.010）。 結論 TG增高是成都市成華區中老年人群的顯著特點，女性HDL-C比男性高；血脂紊亂與胰島素抵抗相關。【Abstract】 Objective To investigate the relationship between blood lipids level and homeostasis model assessment-insulin resistance (HOMA-IR) in elder people in Chengdu. Methods In May 2007, 672 people aged from 50 to 79 years in Chengdu were recruited by random sampling methods for the survey of cardiovascular risk factors. The blood lipids level and HOMA-IR were statistically analyzed. Results ① The serum total cholesterol (TC) and high density lipoprotein chole sterol (HDL-C) were obviously higher in women than those in men (Plt;0.05). ② Triacylglycerol (TG) increased in 30.0% of men and 27.6% of women; HDL-C and low density lipoprotein cholesterin (LDL-C) in most of the involved people were appropriate. ③ HOMA-IR increased as the TG level increased and HDL-C decreased; HOMA-IR increased as the LDL-C level increased, which was significant in the females (Plt;0.05). ④ HDL-C was positively correlated with HOMA-IR (r=-0.145, P=0.000); LDL-C was positively correlated with HOMA-IR (r=0.099, P=0.010). Conclusion The increase of hypertriglyceridemia was the most frequent type of the dislipidemia in the elder people in Chengdu; HDL-C level is higher in women than in men. Dyslipidemia is correlated with insulin resistance.
【摘要】 目的 分析成都地區中老年居民脈壓（pulse pressure， PP）及脈壓指數（pulse presure index，PPI）與高尿酸血癥（hyperuricemia，HUA）的關系。 方法 利用2007年5月代謝綜合征研究調查資料（共1 061人），依據PP[≤60 mm Hg（1 mm Hg=0.133 kPa）、gt;60 mm Hg]和PPI（≤0.450、gt;0.450）將人群分為正常組及增高組，分析兩組人群尿酸水平及HUA患病率，采用單因素回歸及logistic回歸分析PP及PPI與HUA關系。 結果 ①PP/PPI增高組血漿尿酸水平明顯高于PP/PPI正常組，差異有統計學意義（P=0.000）。②PP/PPI增高組HUA患病率明顯高于PP/PPI正常組，差異有統計學意義（P=0.026、0.027）。③單因素回歸和logistic回歸分析皆提示PP及PPI與HUA呈正相關。 結論 成都地區PP及PPI與血漿尿酸水平關系密切，PP/PPI增高可能是HUA的危險因素。【Abstract】 Objective To evaluate the relationship between pulse pressure (PP), pulse pressure index (PPI) and hyperuricemia (HUA) among middle-aged and aged residents in Chengdu. Methods Based on the level of PP [≤60 mm Hg (1 mm Hg=0.133 kPa),gt;60 mm Hg] and PPI (≤0.450,gt;0.450), We divided the 1 061 middle-aged or aged people into normal PP/PPI group and augmented PP/PPI group. All patients came from the survey for metabolic syndrome study in May 2007. We analyzed the distribution of serum uric acid (UA) and HUA, and analyzed the relationship between PP, PPI and HUA by using single-factor and logistic regression analysis. Results The index of UA in the augmented PP/PPI groups was higher than that in the normal groups with a significant difference (P=0.000). The prevalence of HUA in the augmented PP/PPI groups was statistically higher than that in the normal groups (P=0.026, 0.027). Single-factor and logistic regression analysis showed that PP and PPI were both positively correlated to HUA. Conclusion The abnormalities of PP and PPI are closely related to metabolism disorder in Chengdu, and high level of PP or PPI is probably risk factors for HUA.
