Objective To investigate the potential association between diethyltoluamide and the risk of vascular dementia (VaD), and to predict its core targets and molecular mechanisms using network toxicology and molecular docking. Methods The toxicological characteristics and potential targets of diethyltoluamide were predicted using toxicological databases. VaD-related targets were retrieved from disease databases. The STRING database was used to construct a protein-protein interaction network to screen core genes. Pathway enrichment analyses were conducted on the intersecting genes. Finally, the key protein was selected and its binding affinity with diethyltoluamide was verified through molecular docking technology. Results Network toxicology analysis identified 71 common targets of diethyltoluamide and VaD. Core targets included TNF, TP53, ACTB, HSP90AA1, and KRAS. These targets were enriched in cellular response to oxidative stress, inflammatory response, and apoptotic signaling pathway, as well as key signaling pathways including PI3K-Akt, mitogen-activated protein kinase. Molecular docking confirmed that diethyltoluamide exhibited strong binding affinity with these core targets. Conclusions Diethyltoluamide may participate in the pathological process of VaD by directly acting on multiple core targets such as TNF, TP53, and KRAS, thereby interfering with various pathways including neuroinflammation, oxidative stress, and cerebrovascular regulation.
ObjectiveTo explore the efficacy of da Vinci robotic surgical system-assisted radical resection of rectal cancer.
MethodsThe clinical data of 456 patients who received radical resection of rectal cancer by the da Vinci robotic surgical system at the Southwest Hospital from March 2010 to March 2016 were retrospectively analyzed. Operative time, operative blood loss, number of harvested lymph nodes, hospital stay, and morbidity were evaluated.
Resultsda Vinci robotic surgical system-assisted radical resection of rectal cancer were successfully carried out in 445 patients, and other 11 patients were converted to open surgery (2.4%). Of 456 patients, 322 patients underwent anterior resection of rectum procedure (70.6%), 126 patients underwent abdominoperineal excision procedure (27.6%), 8 patients underwent Hartmann procedure (1.8%). The mean operative time was (192±60) min, the mean operative blood loss was (110±93) mL, the mean number of harvested lymph nodes were 19±6, the mean length between distal resection margin and tumor were (3.5±1.8) cm, the mean time for patients taking normal activity was (2.9±1.5) d, the mean time of passage of the first flatus was (2.7±1.7) d, the mean hospital stay was (7.1±1.6) d. Surgical complications occurred in 40 patients (8.8%), and all the patients were recovery before leaving hospital. The mean follow-up time was 29.1-month (3-75 months). There were 70 patients suffered from occurrence or metastasis (16.2%), and 60 patients died (13.9%).
Conclusionda Vinci robotic surgical system-assisted radical resection for rectal cancer is a feasible and safe surgical procedure with the minimal trauma, fast recovery, and satisfactory clinical efficacy.
The American Heart Association published the “2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care” in the journal Circulation in October 2025. The new guideline integrates the previously separate adult survival chains for different scenarios and populations into a unified “six-link survival chain” and provides updates and recommendations for multiple key components. Key updates emphasize the following contents: in basic life support, optimization of rescuers’ and patients’ positions, compression strategies for obese or prone patients, systematic management procedures for foreign-body airway obstruction, and details of automated external defibrillator application; in advanced life support, strengthening the core role of epinephrine and standardizing the use of vasoactive agents; updated resuscitation strategies for special situations (such as exposure to highly pathogenic respiratory pathogens and volatile hydrocarbon poisoning); in post-cardiac arrest care, further updates to respiratory and circulatory support, targeted temperature management, and neurological prognosis assessment; and recommendations at the system of care level, including public access to naloxone, video-based dispatch response, and the establishment of resuscitation centers. This article interprets the core recommendations of the guideline to offer references for clinical practice and education.
