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肝癌侵犯膈肌并自發性胸腔出血一例

鄰近下腔靜脈的肝癌切除術(附12例報告)

THE RELATIONSHIP BETWEEN THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND INITIATION OF CELL CYCLE IN HEPATOMA CELL LINE HEPG2

For research the relationship between the expression of vascular endothelial growth factor (VEGF) and the cell proliferation. The expression of VEGF was evaluated while the cell cycle of hepatoma cell line Hep G2, which was synchronized at G0 phase with serum deprivation, and reinitiated with TPA and blocked with antisense oligonucleotides of c-jun. Results: Hep G2 cell did not express VEGF at G0 phase. TPA could induce the expression of VEGF as well as initiation of cell cycle. The antisense oligonucleotides of c-jun could prohibit the expression of VEGF and arrest the cell cycle at G0 phase. Conclusion: The fact that the expression of VEGF accompanies the initiation of cell cycle suggests that they be regulated by the same singnal pathway, the expression of VEGF may be a marker indicating the proliferation of hepatoma cells.

Radiofrequency Ablation in Treatment for Hepatocellular Carcinoma（Report of 58 Cases）

目的　探討射頻消融術在無法實施手術的原發性肝癌患者中的臨床應用效果。方法　回顧性分析2007年9月至2011年3月期間我院收治的58例由于各種原因無法手術治療的大肝癌（＞5cm）并接受射頻消融治療患者的臨床資料，射頻消融前后結合超聲造影的方法，術后隨訪并定期復查血清甲胎蛋白水平和超聲造影或者肝臟增強CT。結果　58例中無一例發生與射頻消融相關的死亡，22例達到完全消融（37.9%，22/58）。共51例（87.9%，51/58）獲得隨訪，隨訪至2012年5月，隨訪時間（12.6±6.4）個月（2～21個月），隨訪12個月以上患者有20例（39.2%，20/51），有10例（19.6%，10/51）無腫瘤復發或者轉移的跡象。22例達到完全消融的患者無瘤生存時間為（13.6±10.4）個月（3～21個月）；36例未能達到完全消融的患者中，有19例隨訪期間死亡，生存時間（8.3±6.1）個月（4～16個月）。結論　由于各種原因不能接受手術的大肝癌患者，射頻消融作為一種有效、安全治療方法，部分能達到完全消融的效果，而部分作為姑息性治療手段，能一定程度上減輕患者的疼痛，達到提高生活質量的目的。

Treatment Choice on Hepatocellular Carcinoma with Different Types of Portal Vein Tumor Thrombus

CURRENT SURGICAL TREATMENT OF PRIMARY LIVER CANCER IN CHINA

Recent Mould of Comprehensive Treatment for Primary Liver Cancer

Advances in Liver Transplantation

INTERNAL RADIOTHERAPY OF LIVER CANCER

Objective To study the development of internal radiotherapy for liver cancer and the relationship between effects and radiation doses. Methods Literature about internal radiotherapy of liver cancer were collected and reviewed. Results The rational selection of radioactive microsphere,the appropriate control of radiation dosage and the path of internal radiotherapy are crucial in improving the therapy effects and decreasing the complications. Conclusion The two-stage operation of liver cancer which is on the base of combining chemotherapy, radiotherapy and immunotherapy is the way to go of liver cancer therapy.

Clinical Study on Efficacy of Transcatheter Arterial Chemoembolization Combined with Radiofrequency Ablation in Treating Hepatocellular Carcinoma

Objective　To evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) in treating primary hepatocellular carcinoma (HCC). Methods　From March 2004 to March 2006, 137 patients with primary HCC underwent TACE alone (n=87) and TACE+RFA (n=50), respectively, after the interventional treatment, all patients periodically received CT reexaminations and alpha fetoprotein (AFP) measurement. The therapeutic efficacy, AFP level and survival rate between two groups were compared with each other. Results　In TACE group the effective rate (CR+PR) was 34.5%, AFP decreasing amplitude was 54.2%, and 2 years survival rate was 43.7%. While in TACE+RFA group, the effective rate (CR+PR) was 70.0%, AFP decreasing amplitude was 78.0%, and 2 years survival rate was 62.0%, there were significant differences between two groups (P＜0.05). Conclusion　Combined application of TACE and RFA is significantly superior to TACE alone in treatment of primary HCC.