To evaluate the process from systemic inflammatory response syndrome (SIRS) to multiple organ dysfunction syndrome (MODS) and probe the therapeutic strategies for elderly patients, we retrospectively studied the clinical data of SIRS and MODS in 292 elderly patients with surgical abdominal emergency. Results: On admission, the morbidity rate of SIRS was 41.1%. Afterwards the morbidity rate of MODS was 14.2%, and the mortality rate of the elderly patients with SIRS was 11.7%. After 48 hours of therapy, MODS was developed in 40.5% of the cases also with SIRS. Of all the 292 elderly patients, 19 cases (6.5%) developed MODS and 16 patients (84.2%) died. Conclusion: The outcome of the patients with surgical abdominal emergency may be improved if SIRS is early diagnosed, the cause of SIRS after 48 hours therapy is well defined and the body inflammatory response is properly regulated.
This paper reports hat there are 55 cases of complex obdominal surgical diseases in 1422 patients admited for cholecystectomy. 16 of 55 were maliglant diseases, such as gastric carcinoma, gallbladder carcinoma, pancreatic carcinoma, etc, and the others were benigh diseases (cholecysto-duodenal fistula, cholecysto-transverse colonic fistula, petic ulcer…).All the 1422 patients operated in by open cholecystectomy and the mentioned complex obdominal surgical diseases were treated at the samw operative time with cholecystectomy. Such complex surgical diseases could not be treated at the same time, if the operations were laparoscopic chlecystectomy.
【摘要】 目的 探討強化益生元膳食纖維的腸內營養在腹部外科術后患者中的臨床應用。 方法 2008年7月-2010年11月30例接受腹部外科中等以上手術的患者術前隨機分為研究組和對照組,每組15例。研究組患者于術后接受腸內營養,并予以強化益生元膳食纖維;對照組只接受相同的腸內營養支持。觀察指標為術后感染并發癥、胃腸道并發癥、住院時間、抗生素治療時間、C反應蛋白水平和病死率等。 結果 研究組術后住院時間為(10±5) d,對照組為(15±7) d,兩組差異有統計學意義(t=2.251,P=0.033);研究組C反應蛋白水平為(6.6±3.2) mg/L,對照組為(9.8±2.1) mg/L,兩組差異有統計學意義(t=3.238,P=0.003);研究組抗生素治療時間為(5.0±3.5) d,對照組為(6.0±4.8) d,兩組差異無統計學意義(t=0.652,P=0.520)。兩組均無死亡病例;術后研究組2例發生感染并發癥,對照組3例,兩組感染并發癥發生率差異無統計學意義(P=1.000)。兩組患者均能耐受經腸內補充營養素。 結論 與常規腸內營養比較,給予強化益生元膳食纖維的腸內營養能減少腹部外科術后患者的住院時間,降低急性期炎癥反應。【Abstract】 Objective To investigate the effect of early enteral supply of prebiotic fiber in patients undergoing major abdominal surgery. Methods Between July 2008 and November 2010, 30 patients undergoing major gastrointestinal surgery were randomized into the study group and the control group before operation with 15 patients in each group. Prebiotic fiber was administered combined with enteral nutrition support for patients in the study group. Patients in the control group only received conventional enteral nutrition without fiber. The main endpoints included the development of bacterial infection, the duration of hospital stay, antibiotic therapy, the serum level of C-reaction protein (CRP), side effects of the enteral nutrition and morbidity. Results Compared with the control group, the median duration of hospital stay was shorter in the study group [(15±7) days in the control group vs. (10±5) days in the study group; t=2.251, Plt;0.05]. The mean level of CRP was also lower in the study group [(6.6±3.2) mg/L] than that in the control group [(9.8±2.1) mg/L] (t=3.238, Plt;0.05). The enteral nutrition and fibers were well tolerated. The incidence of infectious complications (3 cases in the control group vs. 2 cases in the study group) and the median duration of antibiotic therapy [(6.0±4.8) days in the control group vs. (5.0±3.5) days in the study group] were not significantly different between the two groups (t=0.652, Pgt;0.05). No patients died in both the two groups. Conclusion Compared with the conventional enteral nutrition, early enteral supply of prebiotic fiber can reduce the duration of hospital stay and acute phase response.
Objective To compare the efficacy of incision healing by abdominal wall closure measure without suturing subcutaneous fat layer and the traditional abdominal wall closure measure. Methods Four hundreds patients underwent operation of abdominal median incision and abdominal paramedian incision from Sep. 2010 to Sep. 2012 in our department were randomly assigned to observation group (n=199) and control group (n=201). The patients in obser- vation group underwent abdominal wall closure measure without suturing subcutaneous fat layer, and those of control group were subjected to abdominal wall closure by traditional layer suture technique. Comparison of efficacy of incision healing in the 2 groups was performed. Results The incidences of fat liquefication 〔1 (0.5%) vs.18 (9.0%)〕, incision swelling 〔3 (1.5%) vs.16 (8.0%)〕, incision induration 〔1 (0.5%) vs.15 (7.5%)〕, and dehiscence of wound 〔0 (0) vs.9 (4.5%)〕 in observation group were significantly lower than those of control group (P<0.01), but there was no significant difference in incidence of subcutaneous hematoma 〔2 (1.0%) vs.0 (0), P>0.05〕. The rate of primary healing in obser-vation group was significantly higher than those of control group 〔199 (100%) vs.186 (92.5%), P<0.01〕. Duration of abdominal closure 〔(13.0±1.6) min vs.(18.0±2.2) min〕 and postoperative hospital stay 〔(7.7±1.3) days vs.(9.6±1.9) days〕 were all shorter than those of control group (P<0.01). Conclusion The abdominal wall closure measure without suturing subcutaneous fat layer is obviously more effective to the traditional layer suture technique, which is a suture way worthy to spread.