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Effect of Circadian Variability of Dipper Blood Pressure Induced by Irbesartan in Patients with NonDipper Essential Hypertension on Levels of Aldosterone

摘要:目的：觀察厄貝沙坦治療非杓型高血壓患者降壓效果及其杓型血壓晝夜節律恢復情況,并觀察治療后血漿醛固酮水平的影響。方法:對杓型和非杓型兩組原發性高血壓患者分別給予150300 mg/d,觀察降壓效果及對血壓晝夜節律的影響,并監測用藥前后血漿醛固酮水平的變化。結果:所有高血壓患者應用厄貝沙坦治療前后收縮壓及舒張壓均有不同程度的下降,非杓型組夜間收縮壓及舒張壓的下降值與杓型相比有統計學差異,出現了明顯的晝夜節律,血漿醛固酮水平出現了明顯差異。結論:厄貝沙坦對非杓型高血壓患者有良好的降壓作用,并能恢復非杓型高血壓患者的晝夜節律,向杓型血壓變化。Abstract: Objective: To investigate the effect of blood pressure control and circadian variability of dipper blood pressure induced by irbesartan in patients with nondipper essential hypertension and to observe levels of aldosterone.after treatment.Methods:The patients were divided into dipper and nondipper groups. All patients were treated with irbesartan (150300 mg/d). The variability of circadian blood pressure were observed, and the levels of plasma aldosterone were monitored before and after treatment Results: After the treatment with irbesartan, the blood pressure in all patients were evidently reduced. The night blood pressure of the patient with nondipper essential hypertension had more significant improvement . The circadian variability was appeared. The levels of aldosterone had a significant difference between day and night. Conclusion:Irbesartan has significant effects for the patients with nondipper essential hypertension. It can induce a circadian variability and recover the dipper blood pressure from nondipper blood pressure.