Objective To assess the influence of soy foods intake in Adolescence on the female adult’s breast cancer. Methods Literatures about the influence of soy foods intake in Adolescence on the female adult’s breast cancer were retrieved in The Cochrane Library, MEDLINE, EMbase, CNKI, VIP, WanFang Data and CBM from the date of their establishment to August 2011, meanwhile, the references of included papers were also retrieved. The data were extracted according to the inclusion and exclusion criteria by two reviewers independently, the quality of the included studies was assessed according to the Cochrane Newcastle-Ottawa scale and GRAEDprofiler 3.2.2, and meta-analysis was conducted by using Stata 11.0. Results A total of 6 studies involving 6 609 patients and 79 538 controls were included. The results of meta-analyses showed that compared with the non-intake or low intake of soy foods in Adolescence, high soy foods intake in Adolescence was associated with lower risk of breast cancer (OR=0.816, 95%CI 0.670 to 0.993); In the subgroup analysis, soy foods intake in Adolescence was more effective to prevent premenopausal (OR=0.661, 95%CI 0.550 to 0.796) rather than post-menopausal (OR=0.782, 95%CI 0.486 to 1.259) breast cancer; and the effects of soy foods intake in Adolescence were not significantly different between the eastern (OR=0.793, 95%CI 0.569 to 1.105) and western (OR=0.837, 95%CI 0.743 to 0.943) women. Conclusion Soy foods intake in Adolescence may be associated with a small reduction in the risk of adults’ breast cancer, especially for the premenopausal women, though there is no difference between the eastern and western women. However, restricted by quantity and quality of the studies, this conclusion should be confirmed by more studies.
ObjectiveTo systematically review the influence of childhood psychosocial stress on pubertal emotional and behavioral problems. MethodsThe PubMed, OVID, EBSCO, Web of Science, CBM, VIP, WanFang Data and CNKI databases were electronically searched to collect studies on the relationships between childhood psychosocial stress and pubertal emotional and behavioral problems from inception to February 29, 2024. Two reviewers independently screened the literature, extracted data and assessed the risk of bias in the included studies. Qualitative methods were then used to analyze the data. ResultsA total of 41 cohort studies were included. The outcomes of 19 studies involved pubertal emotional problems, 26 studies involved behavioral problems, and 7 studies involved overall problems. The results showed that depression (14/19) and anxiety (8/19) were the most commonly reported emotional behaviors. Most studies (17/19) showed that childhood psychological stress had a positive predictive effect on pubertal emotional problems. Behavioral problems involved many outcomes, including smoking, drinking, illegal substance use, self-injurious behavior, suicide, externalizing behavior, criminal behavior, bullying behavior, sexual behavior, mobile phone dependence, etc. However, few studies were on the same behaviors, and the relationship between childhood psychosocial stress and behavioral problems was unclear. ConclusionChildhood psychosocial stress may have a positive predictive effect on depression and anxiety. The associations between childhood psychosocial stress and pubertal behavioral problems and other emotional problems remain to be determined by more studies.
Objective Anthropometric variants in prepubertal boys with hypospadias were assigned and assessed to illustrate anatomical malformation. Methods A total of 516 prepubertal (Tanner grade Ⅰ) boys with hypospadias who were admitted to three medical centers between March 2021 and December 2021 and met the selection criteria for primary surgery were selected. The age of the boys ranged from 10 to 111 months, with an average of 32.6 months. Hypospadias were classified according to the location of the urethral defect, 47 cases (9.11%) of the distal type (the urethral defect is in the coronal groove or beyond), 208 cases (40.31%) of the middle type (the urethral defect is in the penis body), and 261 cases (50.58%) of the proximal type (the urethral defect is at the junction or proximal side of the penis and scrotum). The following indexes were measured: penis length before and immediately after operation, reconstructed urethral length, and total urethral length. Morphological indicators of the glans area, including preoperative height and width of glans, AB, BC, AE, AD, effective AD, CC, BB, the urethral plate width of the coronal sulcus, and postoperative height and width of glans, AB, BE, and AD. In which point A is the distal endpoint of navicular groove, point B is the protuberance lateral to the navicular groove, point C is the ventrolateral protuberance of the glans corona, point D is the dorsal midline point of the glans corona, and point E is the ventral midline point of the coronal sulcus. The foreskin morphological indicators, including the foreskin width, inner foreskin length, and outer foreskin length. The scrotal morphological indicators, including the left, right, and front penile to scrotum distance. The anogenital distances, including anoscrotal distance 1 (ASD1), ASD2, anogenital distance 1 (AGD1), and AGD2. ResultsThe penis length of the distal, middle, and proximal types decreased successively before operation, the reconstructed urethral length increased successively and the total urethral length decreased successively, these differences were all significant (P<0.05). The height and width of the glans of the distal, middle, and proximal types significantly decreased successively (P<0.05), but the height/width of the glans was generally close; AB value, AD value, and effective AD value significantly decreased successively (P<0.05); there was no significant difference in BB value, urethral plate width of the coronary sulcus, and (AB+BC)/AD value between the groups (P>0.05). There was no significant difference in the width of glans between the groups after operation (P>0.05); AB value and AB/BE value increased successively, and AD value decreased successively, these differences were all significant (P<0.05). The inner foreskin length in the 3 groups significantly decreased successively (P<0.05), while the outer foreskin length had no significant difference (P>0.05). The left penile to scrotum distance of middle, distal, and proximal types significantly increased successively (P<0.05). ASD1, AGD1, and AGD2 significantly decreased from distal type to proximal type successively (P<0.05). The other indicators’ differences were significant only between some groups (P<0.05).Conclusion The anatomic abnormalities of hypospadias can be described by anthropometric indicators, which can be used as the basis for further standardized surgical guidance.
ObjectivesTo systematically review the association between pubertal development progression and emotional and behavioral problems.MethodsVIP, CNKI, CBM, WanFang Data, PubMed, Web of Science and EBSCO databases were electronically searched to collect studies on the relationship between pubertal tempo or trajectory and emotional and behavioral problems from inception to December 31st, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Qualitative methods were then used to analyze the data.ResultsA total of 14 cohort studies were included. The results showed that depression was the most studied emotional problem, and 2 of the 3 studies found a significant association between faster pubertal tempo and more depressive symptoms in juvenile males. However, no association was found in 3 of the 4 studies on juvenile females. The content of behavioral problems of included studies was broad, including internalizing and externalizing problems, substance abuse, attention problem, self-control, first-sexual experience, delinquency, conduct disorder, peer relationship, etc. However, few studies on the same behaviors, and the relationship between behavioral problems was unclear.ConclusionsThe faster pubertal tempo may be associated with depression in juvenile males. The association between pubertal tempo and behavioral problems in males and females remain to be determined by more studies.
