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The Comparison of the Effect and Nursing between Ordinary Therapy and WLGY 801 Liver Disease Therapy Instrument in Patients with the Virus Hepatitis

目的:評價電腦肝病治療儀治療病毒性肝炎的療效及不良反應。方法:將116例病毒性肝炎患者隨機分為治療組及對照組,治療組60例,對照組56例。兩組均以抗炎、保肝、降酶、退黃、對癥為治則。治療組加用電腦肝病儀治療，每日一次。結果:治療組在消化道癥狀改善方面有效率950%,黃疸消退方面有效率902%。谷丙轉氨酶恢復方面有效率85%。而對照組分別為8214%、6786%和7143%。結論:電腦肝病治療儀治療肝病能迅速改善消化道癥狀,有效降低黃疸、轉氨酶,未見明顯不良反應。

闌尾重復畸形合并急性闌尾炎1例報告

Eotaxin Expression of Airway Smooth Muscle Cells Induced by Sensitized Serum in Rats

Objective To observe the eotaxin expression of rat airway smooth muscle cells ( ASMCs) induced by serum from asthmatic rats, and explore the possible mechanism. Methods ASMCs isolated fromrat tracheas were cultured in vivo. Then they were treated with serum from asthmatic rats, or treated with serum and dexamethasone simultaneously. The level of eotaxin protein in supernatant and eotaxin mRNA in ASMCs were measured by ELISA and reverse transcription-polymerase chain reaction. The expression of cAMP in ASMCs was examined by radioimmunoassay. Results After the treatment with sensitized serum, the eotaxin level in supernatant and mRNA expression in ASMCs were significantly higher [ ( 107. 09 ±7. 12) ng/L vs. ( 0. 63 ±0. 56) ng/L, P lt; 0. 05; 1. 39 ±0. 04 vs. 0. 05 ±0. 01, P lt;0. 05] , and the level of cAMP in ASMCs was significantly lower compared with the control group [ ( 17. 58 ±3. 62) ng/L vs. ( 32. 39 ±3. 36) ng/L, P lt; 0. 05] . After intervened by the sensitized serum and dexamethasone simultaneously, the protein and mRNA expressions of eotaxin were lower compared with those intervened by sensitized serumalone [ ( 64. 18 ±4. 04) ng/L and 0. 77 ±0. 19] . The level of eotaxin in supernatant was negatively correlated with cAMP level in ASMCs ( r = - 0. 788, P lt; 0. 01) . Conclusions There is anautocrine function in ASMCs as inflammatory cells after stimulation with sensitized serum. Eotaxin may play an important roll in the pathogenesis of asthma via a cAMP-dependent pathway.

小劑量糖皮質激素治療急性狼瘡性肺炎一例

The Clinical Efficacy of Specially-made “Yinchen Chaiping Tang” Decoction in Treating Chronic Hepatitis B

目的　觀察茵陳柴平湯治療重度慢性乙型肝炎的療效及不良反應。 方法　2009年3月－2010年3月，選擇采用茵陳柴平湯聯合常規保肝藥物治療50例重度慢性乙型肝炎患者（治療組），并與50例僅用常規保肝藥物治療的重度慢性乙型肝炎患者（對照組）進行比較，觀察治療2、4周時的臨床癥狀、肝功能及凝血酶原活動度等指標的變化。 結果　治療2、4周時，治療組在肝功能及凝血酶原活動度等指標均有顯著改善，無嚴重不良反應；4周時，治療組的癥狀緩解率（84%）明顯高于對照組（66%）；其總有效率（96%）亦高于對照組（80%）。 結論　茵陳柴平湯治療重度慢性乙型肝炎具有較好的臨床療效，且無嚴重不良反應。

嗜酸性肉芽腫性多血管炎 186 例臨床薈萃分析

目的 總結嗜酸性肉芽腫性多血管炎的臨床特征。 方法 以“嗜酸性肉芽腫性多血管炎”、“變應性肉芽腫性血管炎”、“Churg-Strauss 綜合征”為檢索詞，通過中國醫院知識數據庫（CHKD）對 2017 年 1 月以前發表的例數達10 例以上的中文文獻進行檢索，并匯總分析。 結果 符合嗜酸性肉芽腫性多血管炎診斷的病例 186 例，以呼吸系統受累最常見（73.7%），神經系統（68.3%）、皮膚損害（60.2%）、泌尿系統（42.5%）受累也較為常見。腎臟受累較輕，最常見實驗室檢查異常為血嗜酸性粒細胞增高（90.8%）。 結論 嗜酸性肉芽腫性多血管炎臨床表現多樣，早期識別困難，臨床醫生須加強認識，提高警惕，爭取早期診斷，改善預后。

Pathogenesis of Acute Pancreatitis During Pregnancy and The Standardization of Diagnosis and Treatment

ObjectiveTo explore the pathogenesis of acute pancreatitis during pregnancy, differential diagnosis, and standardized treatment. MethodsThe related literatures at home and abroad in recent years were reviewed, and the progress of pathogenesis and treatment of acute pancreatitis during pregnancy were summarized. ResultsThe common cause of acute pancreatitis during pregnancy include biliary system diseases, hyperlipidemia, hyperparathyroidism, the direct effect of pregnancy on the pancreas, etc. According to the different pathogenic factors of acute pancreatitis during pregnancy, the laparoscopic cholecystectomy (LC), endoscopic retrograde cholangiopancreatography (ERCP), low-fat diet combined with Omega-3 fatty acids, parathyroid adenoma resection, or terminal pregnancy could be use. ConclusionAcute pancreatitis during pregnancy is dangerous, the cause, general condition of patients, and the growth of fetus should be give full consideration, and the diagnosis and treatment are standardized.

Old Drug, New Tricks: Metformin in Treatment of Patients with Type 2 Diabetes Mellitus Complicated with Liver Cancer

ObjectiveTo understand the role of metformin on reducing incidence of type 2 diabetes mellitus (T2MD) patients complicated with liver cancer. MethodThe related literatures of metformin treated patients with T2MD complicated with liver cancer at home and abroad in recent years were reviewed. ResultsA large number of epidemiological and clinical data showed that the metformin might prevent the occurrence of the T2MD patients complicated with liver cancer, its mechanism was mainly inhibited the proliferation of hepatoma cells through the ATM-LKB1-AMPK-mTOR pathway, PI3K/Akt/mTOR pathway, or miRNA. The current controversy was the authenticity of the data, the influencing factors included the aging problem and characteristics of metformin user. The prospective study design rigorous remained to be clarified. ConclusionMetformin could reduce the incidence of T2MD patients complicated with liver cancer, and could inhibit the growth of liver cancer cells, which provides a new way of thinking for the comprehensive treatment of liver cancer.

食管黏膜下神經鞘瘤一例

Timing of surgery and exercise training of hip fracture in the elderly

Hip fracture in the elderly is a disease with a high mortality rate and a high complication rate. Its main treatment method is surgery. The concept of enhanced recovery after surgery runs through the perioperative period of elderly patients with hip fracture. Elderly patients with hip fracture should be scheduled for surgery as soon as possible after admission to enhance postoperative functional recovery. Preoperative ambulation and postoperative exercise can reduce postoperative complications and mortality, shorten the length of hospital stay, and promote functional recovery.