ObjectiveTo compare the efficacy of different concentrations of saline irrigation in treatment of chronic rhinosinusitis by network meta-analysis. MethodsThe CNKI, WanFang Data, CBM, VIP, Embase, PubMed and Cochrane Library databases were electronically searched to collect randomized controlled trials on different concentrations of saline irrigation in treatment of chronic rhinosinusitis from inception to March 1, 2024. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. The network meta-analysis was performed by using RevMan 5.4 and Stata 17.0 software. ResultsIn total, 935 patients were enrolled in 15 study. The results of network meta-analysis showed that visual analogue scale sore, nasal mucosal ciliary transport rate and Lund-Kennedy sore of hypertonic saline irrigation group were superior to isotonic saline irrigation group. 2.5% hypertonic saline irrigation had best efficacy in terms of visual analogue scale sore, while 3% hypertonic saline irrigation had best efficacy in terms of mucosal ciliary transport rate and 3.5% hypertonic saline irrigation had best efficacy in terms of Lund-Kennedy sore. ConclusionCurrent evidence indicates that hypertonic saline irrigation has more advantages in terms of clinical efficacy rate, visual analogue scale sore, nasal mucosal ciliary transport rate and Lund-Kennedy sore, while 2.5% hypertonic saline irrigation has more advantages in terms of balancing efficacy and acceptability. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.
Objective To systematically review the effectiveness of endoscopic dacryocystorhinostomy (En-DCR) with versus without Mitomycin C (MMC) for nasolacrimal obstruction. Methods Databases such as PubMed, EMbase, CENTRAL (Issue 12, 2012), VIP, WanFang Data, CBM and CNKI were electronically searched to collect the randomized controlled trials (RCTs) which investigated the comparison between En-DCR with and without MMC for nasolacrimal obstruction. The searched data was updated to December 31st, 2012. According to the inclusion and exclusion criteria, literature was screened, data were extracted, and the methodological quality of the included studies was also assessed. Then, meta-analysis was performed using RevMan 5.2.0 software and the quality of evidences was graded using GRADEpro 3.6 software. Results A total of 9 RCTs were included in the meta-analysis. The results of meta-analysis showed that, the recovery rate in the MMC group was significantly elevated (RR=1.13, 95%CI 1.04 to 1.22, P=0.003), the area of ostium in the MMC group was bigger at 1, 6 and 12 months than in the control group, postoperatively (MD=6.68 mm2, 95% 5.43 to 7.94, Plt;0.000 01; MD=11.61 mm2, 95%CI 4.67 to 18.55, P=0.001; MD=15.65 mm2, 95%CI 2.95 to 28.34, P=0.02), respectively, but the area of ostium in the MMC group at the third month was bigger than that in the control group (MD=8.20 mm2, 95%CI –6.67 to 23.08, P=0.28). The operative time was significantly prolonged in the MMC group (MD=10.1 min, 95%CI 8.00 to 12.20, Plt;0.000 01). Conclusion En-DCR combined with MMC could improve the recovery rate and prevent the over shrinkage of ostium area effectively due to nasolacrimal obstruction.
【摘要】 目的 探討淚囊鼻腔吻合術后復發的原因和手術方法。 方法 對1999年1月-2009年10月因淚道阻塞行淚囊鼻腔吻合術后3個月以上復發的47例患者，行再吻合術，術中仔細分離切除瘢痕及肉芽，盡量做雙瓣吻合。 結果 本組50只眼，術后隨訪3個月～2年，成功49只眼，1例再阻塞，治愈率98%。 結論 首次手術失敗的主要原因是骨孔過小，吻合口粘連，淚囊太小或萎縮，解剖層次不清和手術操作粗暴導致術中出血等。再次吻合手術治療效果滿意。【Abstract】 Objective To explore the reasons of recurrence and the operative method for re-blockage after dacryocystorhinostomy. Methods Forty-seven patients with dacryocystorhinostomy who were recurred after 3 months were included from January 1999 to October 2009. All patients underwent re-anastomosis. The operation required careful separation and resection of scar and granulation, and performed anastomosis with double valve as far as possible. Results All patients were followed up for three months to two years. Operations were successful in 49 eyes of total 50 eyes, and re-obstruction in one case with a cure rate of 98%. Conclusion The major reasons for the failure of the first operation include too small bone hole, anastomotic adhesions, too small or atrophy of lacrimal sac, unclear anatomy and surgical gross bleeding. The best treatment is surgical re-anastomosis.
ObjectiveTo investigate the clinical manifestations, diagnosis, treatment and prognosis of Rosai-Dorfman disease (RDD) in nasal cavity and nasopharynx.
MethodsWe retrospectively analyzed the clinical data of 4 patients with extranodal RDD admitted to the Department of Otolaryngology, Head and Neck Surgery of our hospital between November 2009 and August 2013.
ResultsAll patients received complete surgical removal of the lesions. Histopathological examination showed that large histocytes had an abundant foamy cytoplasm containing ingested lymphocytes as a result of emperipolesis, and were strongly positive for S-100 and CD68 on immunohistochemical analysis, but negative for CD1a. All patients were followed up for 28 to 45 months (averaging 35 months), and no recurrence was observed during the follow-up period.
ConclusionRDD is a rare disease, and the exact etiology and pathogenesis of RDD are not fully understood. There is no unified treatment plan recommended, and complete surgical removal of the lesions is an effective method. Minimally invasive surgery may be a good choice for treatment of this disease.
