ObjectiveTo comprehensively summarize the latest research advances in the epidemiology, pathophysiological mechanisms, imaging diagnostic techniques, and clinical intervention strategies of type Ⅱ endoleak after endovascular abdominal aortic aneurysm repair, so as to provide references for clinical diagnosis and treatment. MethodsRelevant foreign literatures published in recent years were systematically retrieved, and the research on pathophysiological mechanisms, diagnostic methods and treatment strategies of type Ⅱ endoleak was summarized, analyzed and reviewed. ResultsThe core value of matrix metalloproteinases and tissue inhibitors of metalloproteinases in type Ⅱ endoleak lies in diagnosis prediction and disease monitoring. These molecules may be involved in the pathological process of type Ⅱ endoleak, yet their specific mechanisms of action require further investigation. Computed tomography angiography remains the “gold standard” for the diagnosis of type Ⅱ endoleak, while contrast-enhanced ultrasound and magnetic resonance imaging/magnetic resonance angiography can serve as effective supplements. Prophylactic embolization of collateral arteries plays a certain role in delaying the occurrence of type Ⅱ endoleak. Clinical interventions include conservative observation with regular follow-up, endovascular embolization and open surgery, yet a consensus on the optimal regimen has not been reached. ConclusionsClinical diagnosis and treatment of type Ⅱ endoleak still face numerous challenges. In the future, large-sample and multicenter clinical trials should be conducted to clarify the characteristics of its natural course, optimize follow-up and intervention protocols, and further explore its pathophysiological mechanisms, so as to provide new theoretical basis and technical support for the precise diagnosis and treatment of type Ⅱ endoleak.
