ObjectiveTo observe the changes of choroidal blood perfusion in the macular area and the leakage point of acute central serous chorioretinitis (CSC). MethodsA non-randomized controlled clinical study method was adopted. From March 2022 to March 2023, 70 patients (70 eyes) with monocular acute CSC diagnosed in the Eye Center of the Second Hospital of Hebei Medical University (CSC group) were included in this study. There were 49 male patients with 49 eyes and 21 female patients with 21 eyes. The mean age was (46.70±8.45) years. The duration of disease from symptom onset to presentation was ≤3 months. The contralateral eye of the CSC patient was set as the contralateral eye group. A total of 70 eyes of 70 age-and gender-matched healthy volunteers without systemic diseases were selected as normal control group during the same period. The best corrected visual acuity (BCVA) and swept frequency source optical coherence tomography angiography (SS-OCTA) were performed. BCVA was performed using the international standard visual acuity chart, and was converted to log minimum angle of resolution (logMAR) visual acuity. SS-OCTA examination of macular area was performed using VG200D of Vision Micro Imaging (Henan) Technology Co., LTD. Scanning mode Angio 6 mm×6 mm. According to the classification of diabetic retinopathy Treatment Study Group, the choroid within 6 mm of the macular fovea was divided into three concentric circles centered on the macular fovea, which were the central area with a diameter of 1 mm, the inner ring with a diameter of 1-3 mm, and the outer ring with a diameter of 3-6 mm. The three-dimensional choroidal vascular index (3D-CVI), choroidal vascular volume (3D-CVV), choroidal capillary layer (CCL) and choroidal great vascular layer (CL) perfusion area, choroidal thickness (ChT), and subretinal fluid (SRF) height were recorded by the built-in software of the equipment in the central area, inner ring area, and outer ring area. The Kruskal-Wallis rank sum test was used for comparison between multiple groups. ResultsThe logMAR BCVA was 0.19±0.07 in the CSC group. The subfoveal SRF height was (129±121) μm. Compared with the contralateral eye group and the normal control group, the CCL perfusion area in the central area and the inner ring area of the affected eye in the CSC group was significantly decreased, and the CL perfusion area in the central area was significantly increased (P＜0.05). Compared with the normal control group, 3D-CVI was significantly decreased and 3D-CVV was significantly increased in the CSC group, and the differences were statistically significant (P＜0.05). The difference of 3D-CVV between the contralateral eye group and the normal control group was statistically significant (P＜0.05). The ChT of the central, inner and outer ring regions in the CSC group and the contralateral eye group were significantly higher than those in the normal control group (P＜0.05). The CCL and CL perfusion areas at the leakage point in the CSC group were significantly lower than those in the surrounding area, and the 3D-CVI was higher than that in the surrounding area, the differences were statistically significant (P＜0.05). ConclusionCompared with normal healthy eyes, choroidal thickening and vascular dilatation are found in both the affected and contralateral eyes of patients with acute CSC, and the choroidal capillary hypoperfusion and medium and large vascular dilatation are more obvious in the leakage point of the affected eye than in the surrounding area.
Objective To compare changes in retinal and choroidal blood flow in the macular area of eyes with idiopathic macular hole (IMH), fellow eyes, and normal eyes. Additionally, the correlation between these blood flow changes and the occurrence and development of IMH. Methods A cross-sectional study. From January 2023 to January 2024, 47 patients (47 eyes) diagnosed with IMH (IMH group) in Department of Ophthalmology of The Second Hospital of Hebei Medical University were included in the study. The contralateral eye of IMH eyes was assigned to the contralateral eye group. Healthy volunteers with matched gender and age were selected as the normal control group. Swept-source optical coherence tomography angiography was used to acquire the vessel density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the areas within 0-1 mm and 1-6 mm around the fovea, including the superior, temporal, inferior, and nasal regions. Additionally, the choroidal blood flow area (CBFA) and three-dimensional choroidal vascular index (3D-CVI) were measured. The minimum linear diameter (MLD) and base diameter (BD) of the IMH were manually measured. Spearman correlation analysis was performed to evaluate the correlation between the size of the IMH and the various vascular parameters. ResultsCompared with the normal control group, the SCP-VD in the 3rd stage (t=1.298, P=0.009) and 4th stage (t=1.264, P＜0.000) eyes in the IMH group was significantly decreased, with statistical significance; the DCP-VD (t=1.958, 2.150, 1.712, 1.667; P=0.027, ＜0.000, ＜0.000, ＜0.000) and 3D-CVI (t=0.027, 0.030, 0.024, 0.023; P=0.005, 0.003, ＜0.000, ＜0.000) in eyes of all stages were significantly decreased, with statistical significance; the CBFA in eyes of stages 2-4 was significantly decreased, with statistical significance (t=0.027, 0.022, 0.021; P=0.028, 0.002, 0.002). Compared with the contralateral eye group, the DCP-VD and 3D-CVI in the IMH group were significantly reduced, with statistical significance (Z=?3.289, ?2.704; P=0.001, 0.007). Pairwise comparisons between eyes of different stages in the IMH group showed that SCP-VD was significantly different between stage 2 and stage 4 (t=1.776, P=0.008); DCP-VD was significantly different between stage 1 and stage 3, and stage 1 and stage 4 (t=1.685, 1.661; P=0.002, 0.000). Correlation analysis showed that SCP-VD was negatively correlated with MLD and BD (r=?0.508, ?0.408; P=0.002, 0.014); DCP-VD was negatively correlated with BD (r=?0.410, P=0.013). Compared with the normal control group, the nasal CBFA in stage 3 and 4 IMH eyes (t=0.149, 0.145; P=0.005, 0.002), and the nasal 3D-CVI in stage 1 and 3 IMH eyes (t=0.030, 0.027; P=0.002, ＜0.000) were significantly decreased, with statistical significance. ConclusionsThe SCP-VD, DCP-VD, CBFA, and 3D-CVI in IMH eyes were significantly reduced. SCP-VD showed a negative correlation with MLD and BD, while DCP-VD was only negatively correlated with BD.
Objective To observe the hemodynamic changes in the retina and choroid after scleral buckling surgery in eyes with rhegmatogenous retinal detachment (RRD). MethodsA prospective clinical observational study. A total of 25 eyes of 25 patients with RRD who underwent scleral buckling surgery in Tianjin Eye Hospital from February to April 2024 were included in the study. Among them, 10 were male and 15 were female. Age was 17-68 years old. All cases were monocular. The surgical eye and the contralateral healthy eye were divided into the affected eye group and the contralateral healthy eye group respectively. Best corrected visual acuity (BCVA), scanning source optical coherence tomography angiography (SS-OCTA), and axial length (AL) measurements were performed 3 months after surgery. SS-OCTA examination of macular area was performed by VG200 of Visual Microimaging (Henan) Technology Co., LTD. Scanning range 21 mm×26 mm. According to the partitioning method of the early treatment group of glycosuria retinopathy, the retina within 21 mm of the macular fovea was divided into concentric circles with the macular fovea as the center and diameters of 1-3, 3-6, 6-12, 12-21 mm, respectively. The built-in software of the device was used to record the central area (12 mm×12 mm in the fovea of the macula) and the peripheral area (12-21 mm range) retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), radial peripapillary capillaries (RPC) blood density and choroidal vascular index (CVI), choroidal vascular volume (CVV), and 1-3, 3-6, 6-12, 12-21 mm above concentric circles (S), nasal side (N), temporal side (T), and lower side (I) SCP, DCP, and RPC blood flow density. Quantitative data between the two groups were compared by independent sample t test or Wilcoxon signed rank test. The correlation between retinal and choroid blood flow parameters and postoperative BCVA was analyzed by Spearman correlation analysis. ResultsCompared with the opposite healthy eye group, SCP blood density in the central area (Z=?4.372), DCP blood density in the central area (Z=?2.829), and CVI in the peripheral area (Z=?2.138) were decreased in the affected eye group, and the differences were statistically significant (P＜0.05). SCP: in the affected eye group, the blood flow density in T3-6 mm, T6-12 mm, N6-12 mm and T12-21 mm regions decreased, while the blood flow density in I6-12 mm regions increased, with statistical significance (P＜0.05). DCP: blood flow density in S6-12 mm, I6-12 mm, S12-21 mm and I12-21 mm regions decreased significantly, and the differences were statistically significant (P＜0.05). RPC: blood flow density decreased significantly in T6-12 mm and I12-21 mm, and the differences were statistically significant (P＜0.05). CVI: T6-12 mm, S12-21 mm, T12-21 mm, I12-21 mm significantly decreased, and T1-3 mm, S12-21 mm significantly increased, the differences were statistically significant (P＜0.05). Correlation analysis showed that AL growth was positively correlated with CVV in central region (r=0.408, P=0.040) . The number of pad pressure was negatively correlated with the blood density of central DCP (r=?0.422, P=0.030). ConclusionsAfter scleral buckling operation, the blood flow density and choroidal blood flow parameters in RRD affected eyes are lower than those in contralateral healthy eyes in some areas. The increase of AL is positively correlated with CVV in the central region, and the wider the range of pad pressure, the worse the recovery of DCP blood density.
Retinal vein occlusion (RVO) is a serious retinal vascular disease, often accompanied by systemic cardiovascular and cerebrovascular diseases, the eye changes include macular edema, retinal ischemia, and even neovascularization, etc. As a common chronic disease of the fundus, it seriously affects patients' vision and quality of life. With the development of optical coherence tomography, the role of choroid in the occurrence and development of RVO has become a research hotspot. The research on the changes of the choroid layer of the eye with RVO has expanded from a simple two-dimensional thickness analysis to a more comprehensive multidimensional observation index such as three-dimensional volume, blood flow density and velocity. In addition, some cutting-edge research combines artificial intelligence algorithm techniques to improve the accuracy and depth of analysis. In the future, it is still necessary to further improve the data of the choroid layer of the eye with RVO, enhance the overall understanding of RVO, and provide new ideas for clinical prevention and treatment of RVO.
