Objective To analyze the trend of changes in the burden of liver cancer diseases attributed to alcohol consumption in China from 1990 to 2019. Methods Data on liver cancer burden attributed to drinking in China from 1990 to 2019 were obtained from the global burden of disease 2019. Joinpoint regression model was used to analyze the temporal trend of disease burden, and age-period-cohort model was used to evaluate age, period, and cohort effects. Results From 1990 to 2019, the standardized incidence rate of liver cancer attributable to drinking among the total population, men and women showed a downward trend. The AAPC was ?2.52% (95%CI ?2.83% to ?2.21%), 3.26% (95%CI ?3.62% to ?2.89%) and ?2.24% (95%CI ?2.61% to ?1.86%), respectively; The standardized mortality rates showed a decreasing trend, with AAPC values of ?2.86% (95%CI ?3.46% to ?2.26%), ?3.48% (95%CI ?4.20% to ?2.76%), and ?2.67% (95%CI ?2.99% to ?2.34%), respectively; The standardized DALY rates showed a downward trend, with AAPC values of ?3.09% (95%CI ?3.65% to ?2.53%), ?2.92% (95%CI ?3.25% to ?2.58%), and ?3.77 (95%CI ?4.21% to ?3.31%), respectively. The trend changes were statistically significant (P<0.05). From 1990 to 2019, the overall risk of liver cancer incidence and death attributed to drinking in China, both in males and females, showed a trend of first increasing and then decreasing with age; As the period increased, both the overall population and the male population showed a downward trend, followed by an upward trend, while the female population remained relatively stable; The lower the risk of liver cancer incidence and death attributed to drinking as the queue progressed. Conclusion The standardized incidence rate, mortality and DALY rates of liver cancer attributable to drinking in China are generally declining, we should strengthen health education and early diagnosis and treatment for both male and elderly people to reduce the burden of liver cancer.
