ObjectiveAimed to investigate the local neural activity and functional connectivity (FC) in the whole brain of cerebellum by fractional amplitude of low-frequency fluctuation (fALFF) and seed-based FC in right temporal lobe epilepsy (rTLE) patients with different level of executive function. Methods20 healthy controls (HC), 18 rTLE patients with executive nonimpairment (ENI) and 20 rTLE patients with executive impairment (EI) were enrolled. The resting-functional magnetic resonance imaging (rs-fMRI) data of every participant was collected. The local neural activity in the cerebellum was analyzed by fALFF; the cerebral regions with significant zfALFF values among groups were selected as seeds for subsequent FC analyses in the whole brain. ResultsThe fALFF analysis showed that the significantly differential cerebellar regions were located in right cerebellum lobule VIII and left cerebellum lobule VI. Compared with the HC group, the neural functional activity of right cerebellum lobule VIII was increased in the NEI-rTLE and EI-rTLE groups, but no difference between the patient groups. Compared with the HC group, the functional activity of left cerebellum lobule VI was increased in the ENI-rTLE group, decreased in the EI-rTLE group. The further FC analysis showed altered FCs between right cerebellum lobule VIII and right cerebellum lobule IX, right inferior orbitofrontal gyrus, right middle forbitorontal gyrus, right superior frontal gyrus, left middle frontal gyrus and left inferior parietal gyrus, which were increased in the ENI-rTLE patient group while increased and decreased in the EI-rTLE group. ConclusionThe rTLE patients showed that functional activity of cerebellum in the local and whole brain were reorganized, and the cerebellum exerted compensatory and decompensated role in the process of cognitive impairment.
