Objective To clarify the role of gastrokine 1 in the process of formation and development of gastric cancer. Methods The expressions of gastrokine 1 in gastric cancer and paracancerous tissues of 52 patients with gastriccancer were detected by real-time fluorescence quantitative polymerase chain reaction （RT-PCR） and immunohistochemistry. Meanwhile the relationship of the expression level of gastrokine 1 with clinicopathologic characteristics were analyzed. Results The expression levels of gastrokine 1 gene and protein in the gastric cancer tissues were significantly lower than those in the paracancerous tissues （P＜0.01）. No significant relationship was found between expression of gastrokine 1 gene and clinicopathologic features including tumor location， depth of invasion， differentiation， lymph node metastasis， tumor stage， gender， age， and preoperative peripheral blood CEA and CA19-9 levels （P＞0.05，respectively）. What’s more， the expression level of gastrokine 1 gene in gastric cancer tissues of Helicobacter pylori （HP）-positive patients was lower than that in the negative ones （P＜0.05）. Conclusions Gastrokine 1 may play a significant role as an anti-oncogene in the process of the formation and development of gastric cancer. Its effect may become weak due to HP infection in gastric cancer patients.
ObjectiveTo summarize the role and mechanism of gastrokine 1 (GKN1) in the gastric mucosal relative diseases, and to explore the relationship between GKN1 and gastric mucosal relative diseases.
MethodsThe literatures about GKN1 and gastric mucosal relative diseases in recent years were collected to make a review.
ResultsThe expressions of GKN1 gradually declined from gastritis, gastric ulcer to gastric cancer. GKN1 had the effect of protec-ting gastric mucosa, promoting mucosal repairment, and inhibiting the progression of gastric cancer.
ConclusionsGKN1 not only prevents the development of gastric benign diseases to gastric cancer, but also inhibits the progression of gastric cancer, which provides a new idea for the diagnosis and treatment of gastric cancer.
