Objective To formulate an evidence-based nursing methods for a patient with grade III handfoot syndrome induced by capecitabine. Methods Based on the cl inical questions, we searched The Cochrane Library (Issue 1, 2008), ACP Journal Club (1991 to January 2008), MEDLINE (1996 to 2008) and CBMdisc (1995 to 2008). The retrieved studies were further critically appraised. Results There were two effective measures in patients with grade III hand-foot syndrome induced by capecitabine: ① Treatment interruption or dose reduction with supportive measures to reduce pain and discomfort and prevent secondary infection. ② Using Traditional Chinese Medicine and no need of treatment interruption or dose reduction. With patients preference, Treatment interruption and supportive measures were administered to the patient. After two weeks, the patient had a complete response. Conclusions To patients with grade III hand-foot syndrome induced by capecitabine, treatment interruption and supportive measures are effective nursing methods.
