Diabetic macular edema (DME) can occur at any stage of diabetic retinopathy and is the leading cause of vision loss in patients with diabetes. The primary therapeutic strategy for DME is to maximally maintain and improve patients' visual function. The development and progression of DME involve numerous risk factors and complex molecular mechanisms. Currently, there are multiple treatment options for DME in clinical practice, and different drugs and therapeutic regimens offer patients a variety of choices. However, in actual clinical practice, individual patient conditions, such as diabetes duration, glycemic control, age, severity of macular lesions, visual function needs, that pose new challenges for clinicians in formulating appropriate, individualized diagnosis and treatment plans. In such circumstances, the Zhejiang Provincial Professional Committee of Fundus Disease, focusing on key clinical issues in the diagnosis and treatment of DME, has developed this expert consensus based on the latest evidence-based medicine and the Delphi method, aiming to provide guidance and reference for the clinical diagnosis and treatment of DME.