ObjectiveTo systematically review the relationship between Glasgow prognostic score (GPS) and prognosis of gastric cancer (GC) patients. MethodsPubMed, Web of Science, The Cochrane Library, CNKI, CBM and VIP databases were electronically searched to collect cohort studies on the relationship between GPS and prognosis of GC patients from inception to April, 2022. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies; then, meta-analysis was performed by using RevMan 5.3 software and Stata 16.0 software. ResultsA total of 9 cohort studies involving 2 395 patients were included. The results of meta-analysis showed that GPS was significantly associated with poor overall survival of GC patients (HR=2.01, 95%CI 1.55 to 2.61, P<0.000 01). It also was associated with deeper depth of tumor, positive lymph node metastasis, more advanced TNM stages, positive distant metastasis and older age. ConclusionCurrent evidence shows that GPS is associated with survival prognosis and clinical pathological features of GC patients. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
