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Clinical Observation on LowMolecularWeight Heparin with ACEI/ARB for Diabetic Nephropathy

摘要:目的: 觀察低分子肝素聯合ACEI/ARB治療糖尿病腎病(DN)的療效。 方法 :將55例2型DN患者隨機分為對照組(ACEI/ARB)和治療組(ACEI/ARB+低分子肝素),療程8周。比較兩組治療前和治療后24h尿蛋白,Scr、BUN、血漿白蛋白等指標的變化。 結果 :(1)治療后治療組和對照組24h尿蛋白、Scr均顯著下降(〖WTBX〗P lt;001,〖WTBX〗P lt;005),治療組比對照組下降更為明顯(〖WTBX〗P lt;005)。(2)治療后兩組血漿白蛋白均增加(〖WTBX〗P lt;001),治療組與對照組治療后比較無明顯差異(〖WTBX〗P gt;005)。(3)治療后兩組BUN均降低(〖WTBX〗P lt;005),治療組與對照組治療后比較無明顯差異(〖WTBX〗P gt;005)。(4)治療后兩組TC和TG均無明顯變化。 結論 :聯合應用低分子肝素能有效減少DN患者的蛋白尿,改善腎功能。Abstract: Objective: To study the clinical effects of lowmolecularweight heparin (LMWH) and ACEI/ARB on diabetic nephropathy(DN).Methods :55 patients of type 2 Diabetic nephropathy were randomly divided into treatment group(ACEI/ARB+ LMWH)and control group (ACEI/ARB).SCr,quantity of protein in 24hour urine,BUN and plasma albumin figures were compared between two groups before treatment and eight weeks after treatment.Results :(1)SCr,quantity of protein in 24hour urine had been decreased significantly in both groups(P lt;001,P lt;005),and more significantly in treated group than in control group (P lt;005).(2)Plasma albumin increased significantly in both groups(P lt;001).But no significantly increase of plasma albumin had been found in treatment group during the followup(P gt;005).(3)BUN decreased significantly in both groups(P lt;005), but no significantly decrease of BUN had been found in treatment group during the followup(P gt;005).(4)There were no significantly difference in TC and TG between two groups.Conclusion : LMWH and ACEI/ARB can ameliorate proteinuria and improve renal function of the patients with DN.