Chronic kidney disease (CKD) is now recognized as a worldwide public health challenge, and the incidence rate and hospitalization rate have significantly increased in recent years. Without prompt diagnoses and effective treatment in the early renal function damage of CKD, the symptoms will continue to worsen and eventually develop into end-stage renal disease. Functional imaging techniques such as single photon emission computed tomography (SPECT), contrast-enhanced ultrasound (CEUS), computerized tomography perfusion (CTP), and magnetic resonance perfusion weighted imaging (MR-PWI) could be used to quantitatively analyze renal perfusion and renal filtration function. Their diagnostic values are increasingly evident and have become the research hotspot in evaluating renal function. The aim of this review is to briefly evaluate the research and application advances in the early renal function damage assessment of CKD, so as to raise the efficiency of clinical applications.
Prostate cancer is the most common malignant tumor in male urinary system, and the morbidity and mortality rate are increasing year by year. Traditional imaging examinations have some limitations in the diagnosis of prostate cancer, and the advent of molecular imaging probes and imaging technology have provided new ideas for the integration of diagnosis and treatment of prostate cancer. In recent years, prostate-specific membrane antigen (PSMA) has attracted much attention as a target for imaging and treatment of prostate cancer. PSMA ligand positron emission tomography (PET) has important reference value in the diagnosis, initial staging, detection of biochemical recurrence and metastasis, clinical decision-making guidance and efficacy evaluation of prostate cancer. This article briefly reviews the clinical research and application progress on PSMA ligand PET imaging in prostate cancer in recent years, so as to raise the efficiency of clinical applications.
Cross-modal unsupervised domain adaptation (UDA) aims to transfer segmentation models trained on a labeled source modality to an unlabeled target modality. However, existing methods often fail to fully exploit shape priors and intermediate feature representations, resulting in limited generalization ability of the model in cross-modal transfer tasks. To address this challenge, we propose a segmentation model based on shape-aware adaptive weighting (SAWS) that enhance the model's ability to perceive the target area and capture global and local information. Specifically, we design a multi-angle strip-shaped shape perception (MSSP) module that captures shape features from multiple orientations through an angular pooling strategy, improving structural modeling under cross-modal settings. In addition, an adaptive weighted hierarchical contrastive (AWHC) loss is introduced to fully leverage intermediate features and enhance segmentation accuracy for small target structures. The proposed method is evaluated on the multi-modality whole heart segmentation (MMWHS) dataset. Experimental results demonstrate that SAWS achieves superior performance in cross-modal cardiac segmentation tasks, with a Dice score (Dice) of 70.1% and an average symmetric surface distance (ASSD) of 4.0 for the computed tomography (CT)→magnetic resonance imaging (MRI) task, and a Dice of 83.8% and ASSD of 3.7 for the MRI→CT task, outperforming existing state-of-the-art methods. Overall, this study proposes a cross-modal medical image segmentation method with shape-aware, which effectively improves the structure-aware ability and generalization performance of the UDA model.
