Objective To investigate confidence interval estimation for the amount of heterogeneity in meta-analysis. Methods On the basis of BT’s method, the approximate Q-statistic distribution following linear transformation of Chi-square was applied to improve the accuracy of Q-statistic distribution, and to obtain the confidence interval for the amount of heterogeneity in meta-analysis. Results In case, the Q1 distribution obtained 95%CI 0.07 to 2.20, while the Q2 distribution obtained 95%CI 0.00 to 1.41; The proposed method Q2 narrowed down the range of confidence interval. Conclusion On account of improving the accuracy of Q-statistic distribution, the proposed method effectively strengthens the coverage probabilities of the confidence interval for the amount of heterogeneity. And the proposed method can also improve the precision of the confidence interval estimation for the amount of heterogeneity.
The spine is one of the most common sites for bone metastases from malignant tumors, and its incidence is increasing year by year. It often leads to severe pain, pathological fractures, nerve compression, and spinal cord dysfunction, seriously affecting the quality of life of patients. The comprehensive treatment of spinal metastases with both traditional Chinese and Western medicine has shown significant efficacy, especially in improving clinical symptoms, promoting postoperative recovery as soon as possible, and enhancing the quality of life. Based on the latest research progress at home and abroad and from the perspective of clinical application, this guideline, grounded in evidence-based medical evidence, has formed 25 recommendations covering treatment objectives, efficacy evaluation, rational selection of traditional Chinese medicine, treatment plans, and postoperative rehabilitation. It provides diagnostic and therapeutic suggestions for orthopedic oncologists, oncologists, radiologists, pain specialists, and other professionals engaged in traditional Chinese medicine, Western medicine, or integrated traditional Chinese and Western medicine, as well as specialized nurses.
