Search

Activation and Significance of Nuclear Transcription FactorκB in Primary Breast Carcinoma

Objective To investigate the activation and significance of nuclear transcription factorκB (NFκB) in primary breast carcinoma. MethodsImmunohistochemical staining method was used to detect expression of NFκB in 28 cases of primary breast carcinoma and 21 cases of breast tissues closely adjacent to carcinoma tissues. ResultsIt showed that there was expression of NFκB in 28 cases of breast carcinoma tissues and 21 cases of breast tissues closely adjacent to carcinoma. In 21 cases of breast tissues closely adjacent to carcinoma, NFκB was localized mainly in cytoplasm of epithelium cells of ducts and lobular acini. In 28 cases of breast carcinoma NFκB was mainly expressed in cytoplasm and /or nuclei of breast carcinoma cells. Conclusion NFκB is expressed in breast tissues closely adjacent to carcinoma and primary breast carcinoma tissues, and the expression style in the two situation was different. In the breast tissues closely adjacent to carcinoma, NFκB is localized in cytoplasm of epithelium cells of breast acini and duct in an inactive state. In breast carcinoma tissues, NFκB is localized in both cytoplasm and nuclei of carcinoma cells. This study suggests that NFκB is activated in breast carcinoma and plays a significant role in its tumorigenesis and development.